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2026 data Public-data reference. official source

Rhabdomyosarcoma

Open-data reference.

36 US clinical trials · 17 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 135 participants

Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease

St. Jude Children's Research Hospital

NCT06023641

RECRUITING Phase 1 104 participants

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

Milton S. Hershey Medical Center

NCT06541262

RECRUITING NA 70 participants

Targeted Oligometastatic Radiation in Pediatric and Young Adult Patients With Soft Tissue and Bone Sarcoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06796543

RECRUITING Phase 1 63 participants

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

David S Shulman, MD

NCT06709495

RECRUITING Phase 1 50 participants

FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma

National Cancer Institute (NCI)

NCT06865664

RECRUITING Phase 1 40 participants

Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants

Iovance Biotherapeutics

NCT06566092

RECRUITING Phase 1 32 participants

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

St. Jude Children's Research Hospital

NCT04897321

RECRUITING Phase 1 27 participants

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

University of Florida

NCT06625190

RECRUITING Phase 1 25 participants

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

Baylor College of Medicine

NCT04995003

RECRUITING Phase 1 24 participants

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

Baylor College of Medicine

NCT04715191

RECRUITING Phase 1 23 participants

VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

University of Texas Southwestern Medical Center

NCT04796012

RECRUITING Phase 1 22 participants

Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

University of Wisconsin, Madison

NCT02508038

RECRUITING Phase 1 21 participants

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

Baylor College of Medicine

NCT06198296

RECRUITING Phase 1 21 participants

Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells

Seattle Children's Hospital

NCT07148050

RECRUITING Phase 1 20 participants

Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors

ITM Solucin

NCT06441331

RECRUITING Phase 1 20 participants

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Valent Technologies

NCT04337177

RECRUITING Phase 1 18 participants

Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE)

Children's National Research Institute

NCT07172958

ACTIVE NOT RECRUITING Phase 3 325 participants

Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

National Cancer Institute (NCI)

NCT02567435

ACTIVE NOT RECRUITING Phase 2 202 participants

Radiation Therapy to Treat Musculoskeletal Tumors

St. Jude Children's Research Hospital

NCT00186992

ACTIVE NOT RECRUITING Phase 2 128 participants

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Pfizer

NCT03709680

ACTIVE NOT RECRUITING Phase 2 115 participants

Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy

St. Jude Children's Research Hospital

NCT01871766

ACTIVE NOT RECRUITING Phase 1 68 participants

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

NCT04483778

ACTIVE NOT RECRUITING Phase 1 44 participants

EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

NCT03618381

ACTIVE NOT RECRUITING Phase 1 38 participants

Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma

Jonsson Comprehensive Cancer Center

NCT04299113

ACTIVE NOT RECRUITING Phase 1 30 participants

Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas

Cellectar Biosciences

NCT03478462

ACTIVE NOT RECRUITING Phase 1 14 participants

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

Baylor College of Medicine

NCT04377932

ACTIVE NOT RECRUITING Phase 1 12 participants

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors

Baylor College of Medicine

NCT05103631

ACTIVE NOT RECRUITING Phase 2 12 participants

Evolutionary Therapy for Rhabdomyosarcoma

H. Lee Moffitt Cancer Center and Research Institute

NCT04388839

COMPLETED Phase 3 481 participants

Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

Children's Oncology Group

NCT00354835

COMPLETED Phase 2 90 participants

New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma

National Cancer Institute (NCI)

NCT00001335

COMPLETED Phase 1 40 participants

Recombinant Human Thrombopoietin in Children Receiving Ifosfamide, Carboplatin, and Etoposide Chemotherapy

St. Jude Children's Research Hospital

NCT00187109

COMPLETED Phase 2 30 participants

A Pilot Study of Tumor-Specific Peptide Vaccination and IL-2 With or Without Autologous T Cell Transplantation in Recurrent Pediatric Sarcomas

National Cancer Institute (NCI)

NCT00001564

COMPLETED Phase 2 24 participants

A Study of Lymphoseek® as a Lymphoid Tissue Targeting Agent in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping

Cardinal Health 414

NCT02509598

COMPLETED Phase 1 19 participants

Decitabine Followed by a Cancer Antigen Vaccine for Patients With Neuroblastoma and Sarcoma

University of Louisville

NCT01241162

COMPLETED Phase 1 18 participants

HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors

Timothy Cripe

NCT00931931

COMPLETED Phase 1 16 participants

TAA-Specific CTLS for Solid Tumors (TACTASOM)

Baylor College of Medicine

NCT02239861

Phase Distribution

PhaseTrial count
Early Phase 1 25
Phase 2 8
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Rhabdomyosarcoma Trial Landscape

ClinicalTrials.gov lists 36 US studies indexed under Rhabdomyosarcoma, and 17 of those are currently open to recruitment — roughly 47% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Rhabdomyosarcoma shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 33 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Rhabdomyosarcoma is led by Baylor College of Medicine with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 36 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Rhabdomyosarcoma?

PlainTrial tracks 36 US clinical trials for Rhabdomyosarcoma, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Rhabdomyosarcoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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