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NCT06421987 · ClinicalTrials.gov registry record
Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
A clinical trial of Hodgkin Lymphoma, Adult, sponsored by St. Jude Children's Research Hospital.
- Recruiting
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT06421987: Recruiting study of Hodgkin Lymphoma, Adult, sponsored by St. Jude Children's Research Hospital.
NCT06421987 is a study of Hodgkin Lymphoma, Adult that is actively recruiting participants, run by St. Jude Children's Research Hospital. The registered enrollment target is 100 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06421987, a study of Hodgkin Lymphoma, Adult, is actively recruiting participants, sponsored by St. Jude Children's Research Hospital.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
SURVIVORS Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors. Primary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. . Secondary Objectives To examine the degree of CO2 clearance (DLCO/ETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity. CONTROLS Volunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee/affiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.
Primary Outcome
a non-invasive imaging technology that is used to measure regional or global cerebral tissue oxygenation and cerebral blood flow (CBF) during exercise. NIRS takes advantage of the fact that oxygenated blood and de-oxygenated blood absorb light differently. By measuring the reflected light from blood, the concentration of both oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (HbdO2) using the modified Beer-Lambert Law can be calculated.
Conditions Studied
Interventions
- DEVICE Near Infrared Spectroscopy (NIRS)
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2024-05-06 |
| Est. Completion | 2027-03 |
What NCT06421987 shows while recruiting
NCT06421987 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Hodgkin Lymphoma, Adult appearing as the primary indexed condition, and to 1 intervention - of which Near Infrared Spectroscopy (NIRS) is the first listed.
NCT06421987 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT06421987 about?
NCT06421987 is a clinical study titled "Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors". SURVIVORS Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understan...
What is the current status of trial NCT06421987?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2024-05-06. Estimated completion is 2027-03.
What conditions does trial NCT06421987 study?
This clinical trial studies the following conditions: Hodgkin Lymphoma, Adult.
What interventions are being tested in trial NCT06421987?
The interventions under investigation include: Near Infrared Spectroscopy (NIRS) (DEVICE).
Who is sponsoring clinical trial NCT06421987?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06421987 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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