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NCT06819475 · ClinicalTrials.gov registry record · NA
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors
A NA study of Muscle Weakness and Childhood Cancer, sponsored by St. Jude Children's Research Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06819475: Recruiting NA study of Muscle Weakness and Childhood Cancer, sponsored by St. Jude Children's Research Hospital.
NCT06819475 is a NA study of Muscle Weakness and Childhood Cancer that is actively recruiting participants, run by St. Jude Children's Research Hospital. The registered enrollment target is 60 participants, below the 73-participant average among 25 other Muscle Weakness trials with a reported enrollment target (18% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06819475, a NA study of Muscle Weakness and Childhood Cancer, is actively recruiting participants, sponsored by St. Jude Children's Research Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow. Primary Objective • To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls. Secondary Objective * To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors. * To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.
Primary Outcome
Multimodal MR imaging will be performed in two appointments. The first appointment will consist of Part 1 (approximately 1 hour) and Part 2 (approximately 30 minutes). There will be a 5-10 minute break between the two parts. The second appointment will consist of Part 1 (approximately 1 hour).
Conditions Studied
Interventions
- OTHER Physical function assessment
- DIAGNOSTIC_TEST Magnetic Resonance Imaging
- DIAGNOSTIC_TEST Magnetic Resonance Spectroscopy
- OTHER Peripheral blood sample
- OTHER Skeletal muscle biopsy
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-06-02 |
| Est. Completion | 2028-01 |
| Phase | NA |
What NCT06819475 shows while recruiting
NCT06819475 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 73-participant average among 25 other Muscle Weakness trials with a reported enrollment target (18% lower).
The record links to 2 conditions, with Muscle Weakness appearing as the primary indexed condition, and to 5 interventions - of which Physical function assessment is the first listed.
NCT06819475 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT06819475 about?
NCT06819475 is a clinical study titled "Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors". The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL ...
What is the current status of trial NCT06819475?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2025-06-02. Estimated completion is 2028-01.
What conditions does trial NCT06819475 study?
This clinical trial studies the following conditions: Muscle Weakness, Childhood Cancer.
What interventions are being tested in trial NCT06819475?
The interventions under investigation include: Physical function assessment (OTHER), Magnetic Resonance Imaging (DIAGNOSTIC_TEST), Magnetic Resonance Spectroscopy (DIAGNOSTIC_TEST), Peripheral blood sample (OTHER), Skeletal muscle biopsy (OTHER).
Who is sponsoring clinical trial NCT06819475?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06819475 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06819475's enrollment target sits among peer trials
60 12th of 25 higher than 12 of 25 other Muscle Weakness trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Muscle Weakness trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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