Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00136825 · ClinicalTrials.gov registry record · Phase 1
Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1
A Phase 1 study of Cocaine-Related Disorders, sponsored by National Institute on Drug Abuse (NIDA).
- Completed
- Registry status
- Phase 1
- Development phase
- 17
- Enrollment target
- 1
- Study location
NCT00136825: Completed Phase 1 study of Cocaine-Related Disorders, sponsored by National Institute on Drug Abuse (NIDA).
NCT00136825 is a Phase 1 study of Cocaine-Related Disorders that has completed, run by National Institute on Drug Abuse (NIDA). The registered enrollment target is 17 participants, below the 64-participant average among 15 other Cocaine-Related Disorders trials with a reported enrollment target (73% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00136825, a Phase 1 study of Cocaine-Related Disorders, has completed, sponsored by National Institute on Drug Abuse (NIDA).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 17 participants
- Enrollment target
- 1
- Study location
Study Summary
Recent findings have suggested that N-acetylcysteine (NAC) substantially reduces cocaine drug-seeking behavior in formerly cocaine dependent rats. The purpose of this study is to determine the safety, tolerability, and cue reactivity effects of NAC in cocaine dependent individuals and non-dependent healthy controls.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG N-Acetylcysteine
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2003-03 |
| Est. Completion | 2005-09 |
| Phase | Phase 1 |
What the finished NCT00136825 record still lists
NCT00136825 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 64-participant average among 15 other Cocaine-Related Disorders trials with a reported enrollment target (73% lower).
The record links to 1 condition, with Cocaine-Related Disorders appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT00136825 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT00136825 about?
NCT00136825 is a clinical study titled "Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1". Recent findings have suggested that N-acetylcysteine (NAC) substantially reduces cocaine drug-seeking behavior in formerly cocaine dependent rats. The purpose of this study is to determine the safety, tolerability, and cue reactivity effects of NAC in cocaine dependent individuals and non-dependent ...
What is the current status of trial NCT00136825?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 17 participants. The study started on 2003-03. Estimated completion is 2005-09.
What conditions does trial NCT00136825 study?
This clinical trial studies the following conditions: Cocaine-Related Disorders.
What interventions are being tested in trial NCT00136825?
The interventions under investigation include: Placebo (DRUG), N-Acetylcysteine (DRUG).
Who is sponsoring clinical trial NCT00136825?
This trial is sponsored by National Institute on Drug Abuse (NIDA), which has 335 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00136825 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine-Related Disorders
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00136825's enrollment target sits among peer trials
17 11th of 15 higher than 5 of 15 other Cocaine-Related Disorders trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine-Related Disorders trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management
COMPLETED · Phase 1
-
Cocaethylene as a Treatment for Cocaine Dependence - 1
COMPLETED · Phase 1
-
Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic Acid
COMPLETED · Phase 1
-
Cocaine-Methylphendidate Interaction Study - 4
COMPLETED · Phase 1
-
Prepulse Inhibition of Startle in Cocaine Dependence - 7
COMPLETED · Phase 1
-
Progesterone for the Treatment of Cocaine Dependence - 1
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02090140 · 17 participants · NA
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
- NCT03317860 · 17 participants · NA
Improving Measurement and Treatment of Post-stroke Neglect
- NCT04356469 · 17 participants · Phase 2
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children
- NCT04414046 · 17 participants · Phase 2
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia