National Institute on Drug Abuse (NIDA)

335 total trials 14 currently recruiting 292 completed

National Institute on Drug Abuse (NIDA) sponsors 335 registered US clinical trials on ClinicalTrials.gov, 14 of them currently recruiting, and 292 completed. 30 of these trials are in Phase 3-4 (later-stage) and 202 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cocaine-Related Disorders, with 17 trials.

Trial Pipeline

335 total, page 5 of 7

COMPLETED Phase 1

Comparing the Effects of Smoked and Oral Marijuana in Individuals With HIV/AIDS

NCT00079560

COMPLETED Phase 2

Treatment of Opioid/Heroin Dependence: Comparison of Three Medication Dosing Regimens

NCT00218127

COMPLETED Phase 2

Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of Cocaine

NCT00218166

COMPLETED Phase 1

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

NCT00218244

TERMINATED Phase 4

Nicotine Patch for Nicotine Dependence in Individuals With Schizophrenia or Schizoaffective Disorder - 1

NCT00046813

COMPLETED Phase 2

Reserpine for the Treatment of Cocaine Dependence - 1

NCT00033033

COMPLETED Phase 2

A Study of Cabergoline for the Treatment of Cocaine Dependence - 1

NCT00033111

COMPLETED Phase 2

Evaluation of Benztropine for Cocaine Craving - 2

NCT00000333

COMPLETED Phase 2

Ondansetron for the Treatment of Cocaine Dependence - 1

NCT00033085

COMPLETED NA

Randomized Trial of the Positive Action Program in Hawaii Schools

NCT00328445

COMPLETED Phase 2

Serotonin, Impulsivity, and Cocaine Dependence Treatment

NCT00297505

COMPLETED NA

Fluoxetine to Reduce Cocaine Use in Cocaine and Opioid Addicts

NCT00142779

COMPLETED Phase 3

Lofexidine for Opiate Withdrawal - 1

NCT00032942

COMPLETED Phase 2

Integrated Treatment for Cocaine and Mood Disorders - 1

NCT00227812

COMPLETED Phase 3

Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1

NCT00032929

COMPLETED Phase 4

Substance Dependent Teens - Impact of Treating Depression Study 1 - 1

NCT00061113

COMPLETED Phase 2

Reduction of Smoking in Cardiac Disease Patients

NCT00469885

COMPLETED

Physiological, Cognitive and Cerebral Activity Changes as a Function of Cigarette Smoking (With or Without Nicotine) and Tobacco Abstinence

NCT01034384

COMPLETED NA

Blockade Efficacy of Buprenorphine/Naloxone For Opioid Dependence

NCT00134888

COMPLETED Phase 3

Naltrexone Augmentation of Nicotine Patch Therapy - 1

NCT00218153

COMPLETED

Methadone Levels in Breast Milk of Women Taking Methadone for Opiate Addiction - 2

NCT00218010

COMPLETED

Examining the Role of Negative Emotional States on Sedative Drug Use in Individuals With Post-Traumatic Stress Disorder

NCT00244335

COMPLETED Phase 2

Effectiveness of Nefazodone and Bupropion in Treating Marijuana Dependent Individuals

NCT00249509

COMPLETED Phase 1

Medication Adherence Therapy for Opioid Abusing Pain Patients

NCT00249587

COMPLETED Phase 2

Effectiveness of Divalproex Sodium (Depakote) in Treating Children With Temper Outbursts and Severe Mood Swings

NCT00217932

COMPLETED Phase 3

Maintenance Treatment for Abstinent Smokers

NCT00063323

COMPLETED

Chemical Dependency and Smoking Cessation: Patient's Views - 1

NCT00051883

COMPLETED NA

Student Athlete Testing Using Random Notification

NCT00451854

COMPLETED Phase 4

Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14

NCT00015340

COMPLETED Phase 2

Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence

NCT01208935

COMPLETED Phase 2

Progesterone Treatment in Female Smokers - 12

NCT00000295

COMPLETED Phase 4

Bupropion as an Adjunct to the Nicotine Patch Plus CBT

NCT00142831

COMPLETED Phase 2

Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9

NCT00015132

COMPLETED Phase 3

Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10

NCT00000293

COMPLETED Phase 3

Motivation and Patch Treatment for HIV-positive Smokers

NCT00551720

COMPLETED Phase 2

Effects of Labetalol on Nicotine Administration in Humans - 14

NCT00000297

COMPLETED Phase 2

Effects of Carvedilol on Cocaine Use in Humans - 11

NCT00000294

COMPLETED Phase 2

Methylphendidate Treatment of Cocaine Dependent Patients With Attention Deficit Hyperactivity Disorder - 3

NCT00015054

COMPLETED Phase 4

Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

NCT00307203

COMPLETED

PET Assays of Striatal Dopamine Marker in Cocaine Craving

NCT01036516

COMPLETED Phase 2

High Dose Nimodipine Treatment Adjunct - 1

NCT00000332

COMPLETED Phase 2

Role of Metabolites in Nicotine Dependence (3) - 6

NCT00000289

COMPLETED Phase 1

Cocaine-Methylphendidate Interaction Study - 4

NCT00015067

COMPLETED Phase 2

Role of Metabolites in Nicotine Dependence (4) - 13

NCT00000296

COMPLETED Phase 2

Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7

NCT00015106

COMPLETED Phase 2

Effects of Labetalol on Human Cocaine Use - 8

NCT00000291

COMPLETED Phase 1

Buprenorphine Formulation Comparison: Sublingual Tablet vs. Solution - 1

NCT00000320

COMPLETED Phase 2

Temporal Discounting Delayed Outcomes on Opioid-Dependent Outpatients - 20

NCT00000238

COMPLETED Phase 2

Dextroamphetamine as an Adjunct in Cocaine Treatment - 1

NCT00000304

COMPLETED Phase 2

Risperidone for Treatment of Cocaine Dependence in Outpatients - 12

NCT00000347

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What the Pipeline for National Institute on Drug Abuse (NIDA) Shows

According to the ClinicalTrials.gov registry, National Institute on Drug Abuse (NIDA) is linked to 335 US clinical trials across every stage of research activity. Of those, 14 studies are currently recruiting, about 4% of the sponsor's indexed portfolio, and 292 are already marked complete, representing roughly 87% of the total.

The phase mix for National Institute on Drug Abuse (NIDA) reports 30 late-stage studies (Phase 3 and Phase 4 combined) and 202 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute on Drug Abuse (NIDA) is Cocaine-Related Disorders with 17 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.