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NCT00688805 · ClinicalTrials.gov registry record · Phase 1
Effects of Propranolol on Responses to Drug-Related Imagery Scripts
A Phase 1 study, sponsored by National Institute on Drug Abuse (NIDA).
- Terminated
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
NCT00688805 is a Phase 1 study that was terminated before completion, run by National Institute on Drug Abuse (NIDA). The registered enrollment target is 40 participants.
The verdict
NCT00688805, a Phase 1 study, was terminated before completion, sponsored by National Institute on Drug Abuse (NIDA).
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
Study Summary
Background: * Relapse to drug abuse is thought to result, in many cases, from exposure to cues that trigger drug-related memories or emotional associations for example, the association between the sight of a crack pipe and a set of responses such as rapid heartbeat and desire for cocaine. This type of memory is reconsolidated (actively re-stored) each time it is reactivated; however, the reconsolidation process can be disrupted by the drug propranolol, which weakens the link between that memory and an emotional response. * Propranolol is traditionally used to treat high blood pressure and other heart-related conditions. Researchers are interested in studying whether propranolol disrupts reconsolidation of drug-cued memories in individuals who are addicted to cocaine. Objectives: \- To examine whether propranolol can interfere with reconsolidation of cocaine-related memories and reduce cravings and drug use in substance abusers. Eligibility: \- Individuals between 18 and 55 years of age who are current cocaine users enrolled in a methadone treatment program. Design: * The study will involve four long sessions (visits 1, 4, 6, and 14) and 10 short sessions. The short visits will be for monitoring of participants use of drugs and alcohol; the longer visits will involve more tests and lab sessions. Participants will be randomized to either the propranolol or placebo group. * The long sessions will involve the following procedures: * An interview session to develop a personalized drug script/cue set. * A two-hour intervention session with baseline measures, drug administration (propranolol or placebo), and two script-guided imagery sets. This is the only administration of propranolol during the study. * Two follow-up test sessions, 1 and 5 weeks after the intervention session. * Participants will make brief visits to our outpatient clinic for twice-weekly monitoring of ongoing drug use via urine screens and self-report, starting 1 week before the intervention sess
Interventions
- DRUG Placebo
- DRUG Propranolol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2007-12-12 |
| Est. Completion | 2013-12-16 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00688805
The ClinicalTrials.gov registry entry for NCT00688805 describes a study currently listed as terminated, categorized as Phase 1. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute on Drug Abuse (NIDA), which has 335 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00688805 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00688805 about?
NCT00688805 is a clinical study titled "Effects of Propranolol on Responses to Drug-Related Imagery Scripts". Background: * Relapse to drug abuse is thought to result, in many cases, from exposure to cues that trigger drug-related memories or emotional associations for example, the association between the sight of a crack pipe and a set of responses such as rapid heartbeat and desire for cocaine. This type...
What is the current status of trial NCT00688805?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2007-12-12. Estimated completion is 2013-12-16.
What interventions are being tested in trial NCT00688805?
The interventions under investigation include: Placebo (DRUG), Propranolol (DRUG).
Who is sponsoring clinical trial NCT00688805?
This trial is sponsored by National Institute on Drug Abuse (NIDA), which has 335 total clinical trials registered on ClinicalTrials.gov.
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