National Institute on Drug Abuse (NIDA)

335 total trials 14 currently recruiting 292 completed

National Institute on Drug Abuse (NIDA) sponsors 335 registered US clinical trials on ClinicalTrials.gov, 14 of them currently recruiting, and 292 completed. 30 of these trials are in Phase 3-4 (later-stage) and 202 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cocaine-Related Disorders, with 17 trials.

Trial Pipeline

335 total, page 1 of 7

RECRUITING Phase 1

Environment and Alcohol: A Pilot Study

NCT06860607

RECRUITING Early Phase 1

Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making

NCT06561828

RECRUITING

SMART-r: Substance Monitoring and Active Relapse Tracking Repository

NCT06676059

RECRUITING

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

NCT06552741

RECRUITING Phase 3

Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder

NCT06233799

RECRUITING Phase 2

Semaglutide Therapy for Alcohol Reduction (STAR)

NCT06015893

RECRUITING Phase 1

Spironolactone in Alcohol Use Disorder (SAUD)

NCT05807139

RECRUITING

Development and Validation of Learning and Decision-Making Tasks

NCT05707806

RECRUITING NA

Orexin s Role in the Neurobiology of Substance Use Disorder

NCT05630781

RECRUITING NA

Defining Neurobiological Links Between Substance Use and Mental Illness

NCT05538910

RECRUITING Phase 1

Evaluation of the Interactions of Cannabidiol (CBD) With Morphine

NCT05143424

RECRUITING

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

NCT03745339

RECRUITING NA

Mechanism of Non-invasive Magnetic Stimulation

NCT03394066

RECRUITING NA

Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

NCT01036581

NOT YET RECRUITING Phase 1

Phase 1 Study of Oral MG001

NCT07204171

NOT YET RECRUITING Phase 1

VK4-116 Phase I Study With Food-Effect

NCT06808932

NOT YET RECRUITING

Olfactory Function and Model-Based Behavior in People Living With HIV and SUD

NCT07637669

NOT YET RECRUITING Early Phase 1

Causal Mechanisms of Odor-Guided Behavior in Humans

NCT07099092

NOT YET RECRUITING Phase 1

Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)

NCT06868914

TERMINATED NA

Hippocampal Network Changes Following Mindfulness Training in Tobacco Vaping Adolescents in an Open-label, Pilot Study

NCT06503159

COMPLETED Phase 1

SXC-2023 Cocaine Interaction Study

NCT06343532

TERMINATED

Adolescent Vaping Characterization and Parent Views on Adolescent Vaping Protocol

NCT05669716

COMPLETED

Real-world Momentary Assessment of Kratom Use Accompanied by Product Assays: A Natural-history Study for Interdisciplinary Characterization of Kratom Use and Pharmacology

NCT05457803

TERMINATED Phase 2

Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD

NCT04316559

COMPLETED Phase 1

Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder

NCT03896516

TERMINATED NA

Just-In-Time Adaptive Interventions for Addictive Behaviors

NCT03538652

TERMINATED

Imaging Biomarker for Addiction Treatment Outcome

NCT03427424

COMPLETED Phase 1

Comparison of Naloxone Pharmacokinetics

NCT03386591

COMPLETED Phase 2

Lorcaserin in the Treatment of Cocaine Use Disorder

NCT03007394

COMPLETED Phase 1

Evaluation of the Effects of Cannabidiol (CBD) Compared to Delta-9-Tetrahydrocannabinol (THC) and Alprazolam

NCT03398083

COMPLETED

Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder Via Microbiota Investigations: A Pilot Study

NCT03152760

COMPLETED Phase 1

Pharmacokinetic Evaluation of Nalmefene Administered Intranasally to Healthy Volunteers

NCT03129347

COMPLETED NA

Effects of a New Behavioral Intervention on Alcohol Craving and Drinking

NCT02831049

TERMINATED NA

Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use

NCT02927236

COMPLETED Phase 1

Pharmacokinetic Evaluation of Intranasal, Intramuscular, and Oral Naltrexone in Healthy Volunteers

NCT02750748

COMPLETED Phase 2

The Study of AZD8529 for Smoking Cessation in Female Smokers

NCT02401022

COMPLETED Phase 1

Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorcaserin

NCT02393599

COMPLETED Phase 1

Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy Volunteers

NCT02572089

COMPLETED NA

Repetitive Transcranial Magnetic Stimulation Equipment Testing and Pilot Study

NCT02231892

COMPLETED

Impact of Delta Opioid Receptor Gene (OPRD1) Variations on Treatment Outcome in African Americans

NCT02225184

COMPLETED Phase 1

Effects of Cannabis Administration Routes on Human Performance and Pharmacokinetics

NCT02177513

COMPLETED

Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity

NCT01867411

COMPLETED Phase 1

Brain Networks and Addiction Susceptibility

NCT01924468

COMPLETED NA

Nicotine Withdrawal Symptoms and Smoking Relapse

NCT01511614

COMPLETED Phase 2

Laboratory Study of Cannabidiol on the Effects of Smoked Marijuana

NCT01844687

COMPLETED Phase 2

A Multi-Center Trial of Nepicastat for Cocaine Dependence

NCT01704196

COMPLETED NA

Three Strategies for Implementing Motivational Interviewing on Medical Inpatient Units

NCT01825057

COMPLETED Phase 1

Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

NCT01851473

COMPLETED

Studying Nicotine Addiction With Transcranial Magnetic Stimulation

NCT01702948

COMPLETED Phase 1

Factors Affecting Methamphetamine and Opiates Drug Testing

NCT01736332

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What the Pipeline for National Institute on Drug Abuse (NIDA) Shows

According to the ClinicalTrials.gov registry, National Institute on Drug Abuse (NIDA) is linked to 335 US clinical trials across every stage of research activity. Of those, 14 studies are currently recruiting, about 4% of the sponsor's indexed portfolio, and 292 are already marked complete, representing roughly 87% of the total.

The phase mix for National Institute on Drug Abuse (NIDA) reports 30 late-stage studies (Phase 3 and Phase 4 combined) and 202 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute on Drug Abuse (NIDA) is Cocaine-Related Disorders with 17 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.