National Institute of Neurological Disorders and Stroke (NINDS)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Neurological Disorders and Stroke (NINDS) sits in the top decile of US sponsors by registered trial count (#61 of 15,742 sponsors by registered trial count).

567 total trials 48 currently recruiting 467 completed early-phase tilt top decile by trial count

National Institute of Neurological Disorders and Stroke (NINDS): 567 sponsored US clinical trials, 48 recruiting.

National Institute of Neurological Disorders and Stroke (NINDS) sponsors 567 registered US clinical trials on ClinicalTrials.gov, 48 of them currently recruiting, and 467 completed. 16 of these trials are in Phase 3-4 (later-stage) and 158 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 23 trials.

Top-decile sponsor footprint

National Institute of Neurological Disorders and Stroke (NINDS) ranks in the top decile of sponsors by registered trial count (#61 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 70/100

467 of 508 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

567 total, page 4 of 12

TERMINATED

Genetics of Motor Learning

NCT01105845

COMPLETED

The Influence of Sensory Stimuli on Gait Imagery in Patients With Freezing of Gait

NCT01071590

COMPLETED

Screening Protocol for Patients With Stroke

NCT01021033

COMPLETED NA

Physiological Investigations of Movement Disorders

NCT01019343

COMPLETED

Cerebral Activity Related to Primary Motor Stereotypies in Children: An EEG Study.

NCT01037361

TERMINATED

Recording and Modulation of Neuronal Mechanisms During Operant Conditioning: a MEG Study

NCT01006109

COMPLETED Phase 1

50 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Parkinson's Disease

NCT00977184

COMPLETED Phase 1

High-Density Direct Current Brain Polarization

NCT00944931

COMPLETED Phase 1

A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm

NCT00942851

COMPLETED

GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

NCT00931619

COMPLETED

Biomarkers of Risk of Parkinson Disease

NCT00775853

COMPLETED

Changes in the Posterior Parietal Cortex - Primary Motor Cortex Pathway Induced by Motor Training

NCT00904332

TERMINATED

Investigation of Neurofeedback With Real-Time fMRI in Healthy Volunteers and Patients With Hyperkinetic Movement Disorders

NCT00885040

COMPLETED

Effect of Reward on Learning in Motor Cortex

NCT00885131

COMPLETED

Magnetoencephalography in Absence Seizures

NCT00884351

TERMINATED Phase 1

An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-grade Glioma

NCT00880061

COMPLETED

Exploring a Motor Learning Technique Based on the Mirror Motor Neuron System

NCT00872183

COMPLETED Phase 1

Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor

NCT00848172

COMPLETED NA

Using Transcranial Direct Current Stimulation (tDCS) to Enhance the Benefit of Movement Training in Stoke Patients

NCT00783913

COMPLETED

Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome

NCT00755339

TERMINATED

Warfighter Head Injury Study

NCT00754169

COMPLETED

Brain Activity During Strategic Planning

NCT00728741

COMPLETED

Brain Activity in Time Discrimination and Sensory Input

NCT00726050

COMPLETED

Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia

NCT00713414

COMPLETED

Language Mapping in Patients With Epilepsy

NCT00706160

COMPLETED

Autoimmunity in Neurologic Complications of Celiac Disease

NCT00692861

COMPLETED Phase 1

Lithium Treatment for Patients With Spinocerebellar Ataxia Type I

NCT00683943

COMPLETED

Aneurysms and Carotid Artery Block in Newborns

NCT00646672

TERMINATED

Relationship of HHV-6B Virus to Seizures and Brain Injury

NCT00597285

COMPLETED

Association Between Focal Dystonia and Complex Regional Pain Syndrome

NCT00595439

COMPLETED

Motor Cortex Reward Signaling in Parkinson Disease

NCT00558766

COMPLETED Early Phase 1

Neurobiology of Functional Movement Disorder and Non-Epileptic Seizures

NCT00500994

TERMINATED Phase 1

Augmenting Effects of L-DOPS With Carbidopa and Entacapone

NCT00547911

COMPLETED

Brain Changes in Blepharospasm

NCT00500799

COMPLETED

Brain Function in Performance of Motor Tasks

NCT00498329

TERMINATED

Brain Changes in Blepharospasm

NCT00487383

COMPLETED

Movement of Epiglottis During Swallowing

NCT00475943

COMPLETED

Influence of Area of Brain Damage on Brain Reorganization After Chronic Stroke

NCT00474292

COMPLETED Phase 1

Botulinum Toxin to Treat Restless Legs Syndrome

NCT00479154

COMPLETED Phase 1

Effect of Electrical Stimulation (DC Polarization) to the Brain on Memory

NCT00471107

COMPLETED

Measuring Blood Flow in the Brain

NCT00466934

TERMINATED

Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation

NCT00467090

COMPLETED

A Study to Evaluate and Characterize the Effect of Pharmacological Chemicals on Blood From Patients With Gaucher Disease

NCT00465062

COMPLETED

Brain Activity in People With Functional Movement Disorders

NCT00448084

TERMINATED

The Role of Serotonin in Seizures

NCT00439387

COMPLETED Phase 1

Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis

NCT00432900

COMPLETED

Sequence Effect in Parkinson's Disease

NCT00431366

COMPLETED

Spaced Versus Massed Skill Learning

NCT00426465

COMPLETED Early Phase 1

Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

NCT00453505

COMPLETED Phase 1

Direct Current Brain Polarization of the Frontal Lobes

NCT00424216

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 78
Phase 3 11
Phase 4 5

What is open in the National Institute of Neurological Disorders and Stroke (NINDS) pipeline

48 recruiting of 567 indexed (8% open); 467 completed (82%).

Phase mix: 16 late (III/IV) vs 158 early (I/II) (early-phase heavy).

Top condition: Healthy (23 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Neurological Disorders and Stroke (NINDS): open-pipeline peers nationwide

Peers matched on 567 registered trials and 8% open enrollment, not the therapeutic-area sidebar.

National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 5%10%15%20%25% Total trials Recruiting share National Institute of Neurological Disorders and Stroke (NINDS)Children's Hospital Medical Center, CincinnatiUniversity of Maryland, BaltimoreAmgenMerck Sharp & DohmeNational Jewish HealthACADIA PharmaceuticalsTexas Tech University Health Sciences Center, El PasoBoehringer Ingelheim
National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 567 trials (± recruiting share)

Sponsors near 8% open enrollment (± trial volume)

What to do with this National Institute of Neurological Disorders and Stroke (NINDS) page

567 registered trials is a research-attention snapshot, not an endorsement of National Institute of Neurological Disorders and Stroke (NINDS) or any single study.

  • 48 of National Institute of Neurological Disorders and Stroke (NINDS)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Healthy is the condition National Institute of Neurological Disorders and Stroke (NINDS) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Healthy trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

National Institute of Neurological Disorders and Stroke (NINDS) pipeline card: 567 registered trials from official public datasets.Report a data error.