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NCT00467090 · ClinicalTrials.gov registry record
Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation
A clinical trial, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Terminated
- Registry status
- 34
- Enrollment target
NCT00467090: Clinical Trial study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT00467090 is a clinical trial that was terminated before completion, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 34 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00467090 was terminated before completion, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- TERMINATED
- Registry status
- 34 participants
- Enrollment target
Study Summary
This study will identify symptoms and other characteristics of Parkinson s disease that may be associated with changes in a gene called leucine-rich repeat kinase 2 (LRRK2). Changes in this gene have been found in patients with and without a family history of Parkinson s disease. This study will examine people with Parkinson s disease to try to identify how symptoms develop over time. First-degree relatives of patients will also be studied. People 18 years of age or older with Parkinson s disease or people who have a first-degree relative with Parkinson s disease may be eligible for this study. Participants visit the NIH Clinical Center every other year for 10 years for some or all of the procedures listed below. Each visit requires 3-4 days of testing, which may be done on an inpatient or outpatient basis. Telephone interviews are conducted during the alternate years. * History and physical examination. * Smell testing: Subjects are asked to identify 40 different scents. * Sensory testing: Objects with grooves and ridges are touched to subjects fingertips. With their eyes closed, the subjects are asked to say which way the grooves and ridges run on the objects. * Neuropsychological evaluation: Subjects are asked about their memory and thinking and may be asked to complete some pen and paper tests. * Psychiatric evaluation: Subjects are asked about psychiatric symptoms, including anxiety and depression. * Blood drawing: Blood is drawn through a needle in the arm. * Magnetic imaging resonance (MRI) scans of the brain: MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. During the test, subjects lie on a table that can slide in and out of the MRI scanner (a metal cylinder surrounded by a strong magnetic field). The procedure lasts about 30 minutes, during which the subjects may be asked to lie still for up to 5 minutes at a time. * Transcranial sonography (TCS): TCS uses sound waves to obtain images of the brain. Subjects l
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2007-04-23 |
| Est. Completion | 2014-02-03 |
Why NCT00467090 stopped before completion
NCT00467090 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 34 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT00467090 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00467090 about?
NCT00467090 is a clinical study titled "Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation". This study will identify symptoms and other characteristics of Parkinson s disease that may be associated with changes in a gene called leucine-rich repeat kinase 2 (LRRK2). Changes in this gene have been found in patients with and without a family history of Parkinson s disease. This study will exa...
What is the current status of trial NCT00467090?
This trial is currently terminated. The enrollment target is 34 participants. The study started on 2007-04-23. Estimated completion is 2014-02-03.
Who is sponsoring clinical trial NCT00467090?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
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