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NCT00713414 · ClinicalTrials.gov registry record
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia
A clinical trial of Focal Dystonia and Spasmodic Dysphonia, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- 37
- Enrollment target
- 1
- Study location
NCT00713414: Completed study of Focal Dystonia and Spasmodic Dysphonia, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT00713414 is a study of Focal Dystonia and Spasmodic Dysphonia that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 37 participants, above the 28-participant average among 8 other Focal Dystonia trials with a reported enrollment target (32% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00713414, a study of Focal Dystonia and Spasmodic Dysphonia, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- 37 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will examine how the brain controls speech in patients with spasmodic dysphonia, a voice disorder that involves involuntary spasms of muscles in the larynx (voice box), causing breaks in speech. Although the causes of spasmodic dysphonia are unknown, recent studies found changes in brain function in patients with the disorder that may play a role in its development. People between 21 and 80 years of age with adductor spasmodic dysphonia may be eligible for this study. Candidates are screened with the following procedures: Medical history and physical examination. Nasolaryngoscopy to examine the larynx. For this test, the inside of the subject s nose is sprayed with a decongestant and a small, flexible tube called a nasolaryngoscope is passed through the nose to the back of the throat to allow examination of the larynx. The subject may be asked to talk, sing, whistle and say prolonged vowels during the procedure. The nasolaryngoscope is connected to a camera that records the movement of the vocal cords during these tasks. Voice and speech recording to measure the type and severity of voice disorder. Subjects are asked questions about their voice disorder and their voice is recorded while they repeat sentences and sounds. Participants undergo positron emission tomography (PET) and magnetic resonance imaging (MRI) of the brain, as follows: PET: A catheter is placed in a vein in the subject s arm to inject a radioactive substance called a tracer that is detected by the PET scanner and provides information on brain function. \[11C\]flumazenil is used in one scanning session and \[11C\]raclopride is used in another. For the scan, the subject lies on a bed that slides in and out of the doughnut-shaped scanner, wearing a custom-molded mask to support the head and prevent it from moving during the scan. For the first scan the subject lies quietly for 60 minutes. For the second scan, the subject lies quietly for 50 minutes and is then asked to say sentences d
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2008-07-09 |
| Est. Completion | 2016-09-21 |
What the finished NCT00713414 record still lists
NCT00713414 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 37 participants, a relatively small participant target, above the 28-participant average among 8 other Focal Dystonia trials with a reported enrollment target (32% higher).
The record links to 2 conditions, with Focal Dystonia appearing as the primary indexed condition, and to 0 interventions.
NCT00713414 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00713414 about?
NCT00713414 is a clinical study titled "Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia". This study will examine how the brain controls speech in patients with spasmodic dysphonia, a voice disorder that involves involuntary spasms of muscles in the larynx (voice box), causing breaks in speech. Although the causes of spasmodic dysphonia are unknown, recent studies found changes in brain ...
What is the current status of trial NCT00713414?
This trial is currently completed. The enrollment target is 37 participants. The study started on 2008-07-09. Estimated completion is 2016-09-21.
What conditions does trial NCT00713414 study?
This clinical trial studies the following conditions: Focal Dystonia, Spasmodic Dysphonia.
Who is sponsoring clinical trial NCT00713414?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00713414 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00713414's enrollment target sits among peer trials
37 2nd of 8 the highest of 8 other Focal Dystonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Focal Dystonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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