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NCT00755339 · ClinicalTrials.gov registry record
Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome
A clinical trial of Tourette Syndrome and Tic Disorder, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- 54
- Enrollment target
- 1
- Study location
NCT00755339: Completed study of Tourette Syndrome and Tic Disorder, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT00755339 is a study of Tourette Syndrome and Tic Disorder that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 54 participants, below the 85-participant average among 33 other Tourette Syndrome trials with a reported enrollment target (36% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00755339, a study of Tourette Syndrome and Tic Disorder, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- 54 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will investigate the sensation that many people with Tourette syndrome (TS) experience before they have a motor tic. It will also test whether blocking the sensation causes the tic to stop. People between 18 and 65 years of age with TS who have at least once tic involving an arm may be eligible for this 3-part study. Those enrolled may participate in all parts or in part 1 or part 2. Those who choose to participate in part 3 must first complete part 2. All must stop taking medication for TS and any other medication that may affect the brain for at least 1 week before the study. Part 1 After numbing the skin or muscles of the arm or leg where a pre-tic sensation is experienced, the response of the nerves will be tested by asking subjects to rate the strength of the sensation after a pinprick and by stimulating the nerves with small electrical shocks. Then, over the course of approximately one hour, subjects will report pre-tic sensations while their motor tics are counted. The onset of each tic will be identified with EMG, a test using electrodes on the skin to indicate the activity of the muscles. Part 2 Subjects brain waves are recorded using magnetoencephalography (MEG) while they are experiencing tics andpre-tic sensory experiences. MEG is a test that records magnetic field changes produced by brain activity. Subjects sit in a chair under a dome containing magnetic field detectors. They watch a clock and report the time a sensory experience starts. Tics are recorded with EMG. Later, a standard MRI of the brain (scan using a magnetic field and radio waves) is done to see which parts of the brain produced the activity recorded with MEG. Part 3 Repetitive transcranial magnetic stimulation (rTMS) is used to try to stop the pre-tic sensations. For TMS, the subject sits in a chair. A wire coil is held on the subject s scalp, and a brief electrical current is passed through the coil, creating a magnetic pulse that stimulates a region of the brain. The
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2008-09-15 |
| Est. Completion | 2016-10-25 |
What the finished NCT00755339 record still lists
NCT00755339 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 54 participants, a relatively small participant target, below the 85-participant average among 33 other Tourette Syndrome trials with a reported enrollment target (36% lower).
The record links to 2 conditions, with Tourette Syndrome appearing as the primary indexed condition, and to 0 interventions.
NCT00755339 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00755339 about?
NCT00755339 is a clinical study titled "Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome". This study will investigate the sensation that many people with Tourette syndrome (TS) experience before they have a motor tic. It will also test whether blocking the sensation causes the tic to stop. People between 18 and 65 years of age with TS who have at least once tic involving an arm may be e...
What is the current status of trial NCT00755339?
This trial is currently completed. The enrollment target is 54 participants. The study started on 2008-09-15. Estimated completion is 2016-10-25.
What conditions does trial NCT00755339 study?
This clinical trial studies the following conditions: Tourette Syndrome, Tic Disorder.
Who is sponsoring clinical trial NCT00755339?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00755339 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tourette Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00755339's enrollment target sits among peer trials
54 16th of 33 higher than 17 of 33 other Tourette Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tourette Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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