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NCT00471107 · ClinicalTrials.gov registry record · Phase 1
Effect of Electrical Stimulation (DC Polarization) to the Brain on Memory
A Phase 1 study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- Phase 1
- Development phase
- 45
- Enrollment target
NCT00471107: Completed Phase 1 study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT00471107 is a Phase 1 study that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 45 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (25% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00471107, a Phase 1 study, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 45 participants
- Enrollment target
Study Summary
This study will test the effect of direct current (DC) brain polarization (the application of a very weak electrical current to the brain) on learning and memory. Earlier studies have shown that DC polarization can temporarily improve the ability of healthy people to think of certain words. This study will explore whether it can also temporarily improve learning and memory. Healthy people 18 years of age and older may be eligible for this study. Subjects participate in two experimental sessions at the NIH Clinical Center. The first session lasts about 1 hour; the second session, on the next day, takes about 10 minutes. At the beginning of the first session, electrodes are placed on the subject's head and arm for brain stimulation. The current may be turned on for 25 minutes, or only very briefly (sham stimulation). Subjects are not told which type of stimulation they are receiving. No stimulation is applied in the second session. During the sessions subjects are asked to complete the following tasks that will help elucidate the effects of polarization: * Read a list of words and remember them. Later they will try to repeat the words from memory. * Look at a series of designs and remember them. Later they will try to draw the designs from memory. * Push a button on a keyboard when they see a specific item (for example, when the number 7 appears). * Generate as many words as they can think of that begin with a particular letter of the alphabet. Subjects may be videotaped for some or all of the time during the sessions.
Primary Outcome
The Wechsler Memory Scale (WMS-III) is a neuropsychological test designed to measure different memory functions. The WMS-III Word Lists is a measure of verbal learning ability. The examiner reads a list of 12 semantically unrelated words and the subject immediately recalls as many words as possible. For this study, the primary outcome is a measure of verbal recall performance at 24 hours following presentation of the words under three conditions, i.e., anodal tDCS, cathodal tDCS, and sham. Score
Interventions
- DEVICE DC brain polarization
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2007-05 |
| Est. Completion | 2010-04 |
| Phase | Phase 1 |
What the finished NCT00471107 record still lists
NCT00471107 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (25% lower).
The record links to 0 conditions, and to 1 intervention - of which DC brain polarization is the first listed.
NCT00471107 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00471107 about?
NCT00471107 is a clinical study titled "Effect of Electrical Stimulation (DC Polarization) to the Brain on Memory". This study will test the effect of direct current (DC) brain polarization (the application of a very weak electrical current to the brain) on learning and memory. Earlier studies have shown that DC polarization can temporarily improve the ability of healthy people to think of certain words. This stu...
What is the current status of trial NCT00471107?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 45 participants. The study started on 2007-05. Estimated completion is 2010-04.
What interventions are being tested in trial NCT00471107?
The interventions under investigation include: DC brain polarization (DEVICE).
Who is sponsoring clinical trial NCT00471107?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00471107's enrollment target sits among peer trials
45 1066th of 2000 higher than 915 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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