National Institute of Mental Health (NIMH)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Mental Health (NIMH) sits in the top decile of US sponsors by registered trial count (#103 of 15,742 sponsors by registered trial count).

343 total trials 42 currently recruiting 256 completed early-phase tilt top decile by trial count

National Institute of Mental Health (NIMH): 343 sponsored US clinical trials, 42 recruiting.

National Institute of Mental Health (NIMH) sponsors 343 registered US clinical trials on ClinicalTrials.gov, 42 of them currently recruiting, and 256 completed. 29 of these trials are in Phase 3-4 (later-stage) and 106 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 21 trials.

Top-decile sponsor footprint

National Institute of Mental Health (NIMH) ranks in the top decile of sponsors by registered trial count (#103 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 56/100

256 of 296 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.5%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

343 total, page 6 of 7

COMPLETED

Fear Conditioning Using Computer-Generated Virtual Reality

NCT00025844

COMPLETED

Examination of Brain Serotonin Receptors in Patients With Mood Disorders

NCT00026832

COMPLETED Phase 4

Clonazepam and Paroxetine for Rapid Treatment of Post-Traumatic Stress Disorder

NCT00025740

COMPLETED NA

Methylphenidate in Children and Adolescents With Pervasive Developmental Disorders

NCT00025779

COMPLETED Phase 2

Clinical Trial of Pramipexole in Bipolar Depression

NCT00025792

COMPLETED Phase 4

Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

NCT00021528

COMPLETED

Adolescence, Puberty, and Emotion Regulation

NCT00016731

COMPLETED Phase 2

Clinical Trial of Propranolol for Seasonal Affective Disorder

NCT00016666

COMPLETED Phase 2

Pilot Study of Levetiracetam (Keppra® (Registered Trademark)) for Bipolar Illness

NCT00015769

COMPLETED Phase 1

Effects of an Anti-Inflammatory Drug in Alzheimer's Disease

NCT00013650

COMPLETED NA

CATIE-Alzheimer's Disease Trial

NCT00015548

COMPLETED

Brain Imaging in Children With AD/HD

NCT00008892

COMPLETED NA

Effects of Arousal and Stress in Anxiety

NCT00026559

COMPLETED Phase 4

CATIE- Schizophrenia Trial

NCT00014001

COMPLETED NA

Treatment of Youth With ADHD and Anxiety

NCT00012584

COMPLETED

Use of Transcranial Magnetic Stimulation (TMS) and Magnetic Resonance Imaging (MRI) to Study Visual Attention

NCT00006285

COMPLETED

Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study

NCT00006177

COMPLETED Phase 4

Bone Loss in Premenopausal Women With Depression

NCT00006180

COMPLETED Phase 2

Glycine to Treat Psychotic Disorders in Children

NCT00005658

COMPLETED

Combined Hormone Replacement in Menstrually-Related Mood Disorders

NCT00005011

COMPLETED

Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers

NCT00004571

COMPLETED

Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions

NCT00004550

COMPLETED

The Effect of Acetylcholine on Memory and Attention

NCT00001977

COMPLETED

Heart Disease Risk Factors in Major Depression

NCT00001969

COMPLETED Phase 2

Omega-3 Fatty Acids in the Treatment of Bipolar Disorder: A Double-Blind, Placebo-Controlled Trial

NCT00001146

COMPLETED

Electrophysiology and Blood Flow in Patients With Schizophrenia and Their Siblings

NCT00001921

COMPLETED

Neuroimaging of St. John's Wort-Induced Changes of Serotonin Metabolism in Normal Subjects

NCT00001919

COMPLETED

Eye Blink Response in Healthy Volunteers and Adults With Schizophrenia

NCT00001920

COMPLETED

L-5-HTP-Related EMS

NCT00001918

COMPLETED

Brain Imaging in Elderly People and Individuals With Alzheimer's Disease

NCT00001917

COMPLETED

Use of Bone Biopsy to Better Understand the Causes of Decreased Bone Mineral Density in Depression

NCT00001916

COMPLETED Phase 3

Behavior Therapy for Children and Adolescents With Obsessive-Compulsive Disorder (OCD)

NCT00000386

COMPLETED NA

Treatment of Major Depression With St. John's Wort (Hypericum)

NCT00005013

COMPLETED

The Impact of Familiarity and Emotional Attachment on the Visual Processing of Faces

NCT00001913

COMPLETED

Evaluation of Patients With Rapid Cycling Bipolar Disorder (RCBD)

NCT00001772

COMPLETED Phase 3

Treatment for Adolescents With Depression Study (TADS)

NCT00006286

COMPLETED NA

Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

NCT00012558

COMPLETED

I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers

NCT00001771

COMPLETED Phase 3

Self-Management Therapy for Youth With Schizophrenia

NCT00000387

COMPLETED NA

Study of Fluoxetine in Patients With Depersonalization Disorder

NCT00004446

COMPLETED NA

Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

NCT00004451

COMPLETED

Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)

NCT00001770

COMPLETED Phase 3

Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)

NCT00001768

COMPLETED Phase 3

Treatment of Autism in Children and Adolescents

NCT00005014

COMPLETED Phase 4

Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections

NCT00001658

COMPLETED

Consequences of Conjugal Bereavement in Adults

NCT00001659

COMPLETED Phase 4

Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders

NCT00001656

COMPLETED

Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Chronic Posttraumatic Stress Disorder (PTSD)

NCT00001657

COMPLETED

The Role of Emotion in the Development of Psychopathology

NCT00001654

COMPLETED Phase 4

Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive Disorder

NCT00000375

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Phase Distribution

PhaseTrial count
Phase 1 61
Phase 2 45
Phase 3 8
Phase 4 21

What is open in the National Institute of Mental Health (NIMH) pipeline

42 recruiting of 343 indexed (12% open); 256 completed (75%).

Phase mix: 29 late (III/IV) vs 106 early (I/II) (early-phase heavy).

Top condition: Healthy (21 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Mental Health (NIMH): open-pipeline peers nationwide

Peers matched on 343 registered trials and 12% open enrollment, not the therapeutic-area sidebar.

National Institute of Mental Health (NIMH) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0100200300400 5%10%15%20%25% Total trials Recruiting share National Institute of Mental Health (NIMH)Children's Oncology GroupMontefiore Medical CenterOhio State University Comprehensive Cancer CenterCedars-Sinai Medical CenterAugusta UniversityUniversity of IowaDaiichi SankyoFriends Research Institute
National Institute of Mental Health (NIMH) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Mental Health (NIMH) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 343 trials (± recruiting share)

Sponsors near 12% open enrollment (± trial volume)

What to do with this National Institute of Mental Health (NIMH) page

343 registered trials is a research-attention snapshot, not an endorsement of National Institute of Mental Health (NIMH) or any single study.

  • 42 of National Institute of Mental Health (NIMH)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Healthy is the condition National Institute of Mental Health (NIMH) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Healthy trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Mental Health (NIMH) pipeline card: 343 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.