Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Major Depression: full-pipeline trial registry
7 of 29 indexed Major Depression trials are currently recruiting.
Corpus placement: #552 of 28,707 conditions by registered trial count.
29 US clinical trials · 7 currently recruiting · #552 of 28,707 conditions by registered trial count
Major Depression: 29 US clinical trials tracked, 7 recruiting.
Major Depression is the subject of 29 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Mental Health (NIMH), running 5 of these trials.
Enrollment posture brief
Registry condition major-depression
OPEN 7 | RECR 24% | LATE 9 | EARLY 6 | RANK #552 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Burnout, Professional (24% recruiting · 29 trials)
Major Depression lists 7 open slots (24% of 29 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Major Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Major Depression is recruiting below its size-band peers.
7 of 29 indexed trials (24.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
One sponsor concentrates Major Depression research.
National Institute of Mental Health (NIMH) accounts for 5 of 29 trials (17.2%). 20 distinct sponsors appear on at least one study for this condition label.
-
Typical Major Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 29 trials that report a genuine target (sentinel values excluded). 14 of those (48.3%) plan for fewer than 100 participants.
-
Major Depression research is mostly interventional.
22 interventional and 7 observational studies make up this index (75.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
29 total, page 1 of 1
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
National Institute of Mental Health (NIMH)
NCT05669703
University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
NCT04480918
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
University of Southern California
NCT02434393
Leucine in Midlife Depression
Emory University
NCT06580145
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
National Institute of Mental Health (NIMH)
NCT03973268
Ketamine Alcohol (in Treatment-Resistant Depression)
Mark Niciu
NCT02122562
Accelerated High-Dose tDCS for Depression
Medical University of South Carolina
NCT07226011
Person-Centered Versus Measurement-Based Care in Mental Health
University of Pittsburgh
NCT02507349
Implementation of Harmonized Depression Outcome Measures in a Primary Care Registry and a Mental Health Registry
OM1
NCT04235725
Duke Conte Center for the Neuroscience of Depression in Late Life
Duke University
NCT00576875
Prozac Treatment of Major Depression: Discontinuation Study
New York State Psychiatric Institute
NCT00427128
Preventing Depression Recurrence in Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00374426
The Effectiveness of FMPO in Improving the Quality of Care for Persons With Severe Mental Illness.
US Department of Veterans Affairs
NCT00466323
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
Hadassah Medical Organization
NCT00158990
Motivational Interviews for Depression in Primary Care
Denver Health and Hospital Authority
NCT01114334
Increasing Use of Mental Health Services
Weill Medical College of Cornell University
NCT00605358
Serum Markers as a Bioassay for Unipolar Depression
Steward St. Elizabeth's Medical Center of Boston
NCT00825799
Thyroid Medication and Antidepressants for Treating Major Depression
Emory University
NCT00208702
Provigil in Conjunction With SSRIs for the Treatment of Mild or Moderate Depression With Attendant Symptoms of Sleepiness and Fatigue.
Emory University
NCT00208715
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.
Mayo Clinic
NCT03156504
Lexapro and Pramipexole and to Treat Major Depression
National Institute of Mental Health (NIMH)
NCT00086307
Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study
Massachusetts General Hospital
NCT02253225
Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental Illness
Massachusetts General Hospital
NCT02594696
Pharmacotherapy in Depression With Panic Spectrum
University of Pittsburgh
NCT00177996
The Brain on Whole Body Hyperthermia: A Neuroimaging Study
University of Arizona
NCT02062840
Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder
National Institute of Mental Health (NIMH)
NCT02484456
Study of Brain Response to Emotional Pictures Using a Magnetic Resonance Imaging (fMRI) While on Escitalopram
Indiana University School of Medicine
NCT00707863
Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy
Conrad, Erich J., M.D.
NCT00595699
Antidepressant Effects of NR2B in Major Depression
National Institute of Mental Health (NIMH)
NCT00472576
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 4 |
| Phase 3 | 1 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Major Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Major Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Major Depression page
29 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 7 Major Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Mental Health (NIMH) sponsors the most Major Depression trials on record, review their full trial history before evaluating a specific study. See National Institute of Mental Health (NIMH)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Major Depression condition card totals 29 registered trials; most-linked intervention sertraline; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.