National Institute of Mental Health (NIMH)
Open enrollment with an early-phase pipeline tilt
According to ClinicalTrials.gov-derived indexes, National Institute of Mental Health (NIMH) sits in the top decile of US sponsors by registered trial count (#103 of 15,742 sponsors by registered trial count).
National Institute of Mental Health (NIMH): 343 sponsored US clinical trials, 42 recruiting.
National Institute of Mental Health (NIMH) sponsors 343 registered US clinical trials on ClinicalTrials.gov, 42 of them currently recruiting, and 256 completed. 29 of these trials are in Phase 3-4 (later-stage) and 106 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 21 trials.
Top-decile sponsor footprint
National Institute of Mental Health (NIMH) ranks in the top decile of sponsors by registered trial count (#103 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.
Trial completion reliability score
256 of 296 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.5%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.
Open and recent trials
343 total, page 1 of 7
PET Imaging of Noradrenergic Transmission in the Brain
NCT07686393
Evaluation of [11C]ZTP-1 to Image PDE4B
NCT07625345
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
NCT07169630
Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)
NCT07027839
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
NCT06920628
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
NCT06874205
PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder
NCT06795581
Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers
NCT06484088
Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety
NCT06595953
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
NCT06511908
Natural History of Depression, Bipolar Disorder and Suicide Risk
NCT06462196
Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial
NCT05608434
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
NCT05669703
State-dependent Interoception, Value-based Decision-making, and Introspection
NCT05666726
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
NCT05703685
Developing Brain, Impulsivity and Compulsivity
NCT04631042
Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array
NCT04950309
Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations
NCT04639830
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
NCT04396873
Long-term Observation of Participants With Mood Disorders
NCT04877977
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
NCT04582916
Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder
NCT04798274
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
NCT03973268
Characterization and Treatment of Adolescent Depression
NCT03388606
Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies
NCT03304665
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
NCT03065335
Neurobiology of Suicide
NCT02543983
Psychological Treatments for Youth With Severe Irritability.
NCT02531893
Brain Stimulation and Vision Testing
NCT01617408
Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
NCT01778504
Top-Down Attentional Control of Visual-Processing
NCT01087281
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty
NCT01434368
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
NCT01266577
Defining the Brain Phenotype of Children With Williams Syndrome
NCT01132885
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
NCT00397111
MRS Measurement of Glutamate and GABA Metabolism in Brain
NCT00109174
The Neurodevelopmental and Behavioral Phenotyping Screening Protocol
NCT00271622
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
NCT00025935
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
NCT00018057
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
NCT00024635
Studies of Blood Flow to the Brain During Thought
NCT00001360
Study of Premenstrual Syndrome and Premenstrual Dysphoria
NCT00001177
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
NCT05172271
Evaluation of the Genetics of Bipolar Disorder
NCT00001174
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers
NCT00001246
Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive Psychotherapy
NCT07640802
Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
NCT07566468
[11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine
NCT05522673
[18F]SF12051 for Imaging the 18-kDa Translocator Protein (TSPO) in Brain and Whole Body of Healthy Subjects
NCT05564429
PET Imaging of Cyclooxygenase in Multiple Sclerosis
NCT05062083
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 61 |
| Phase 2 | 45 |
| Phase 3 | 8 |
| Phase 4 | 21 |
Therapeutic Areas
What is open in the National Institute of Mental Health (NIMH) pipeline
42 recruiting of 343 indexed (12% open); 256 completed (75%).
Phase mix: 29 late (III/IV) vs 106 early (I/II) (early-phase heavy).
Top condition: Healthy (21 trials), 9 others listed.
How open-pipeline share is computed
Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.
National Institute of Mental Health (NIMH): open-pipeline peers nationwide
Peers matched on 343 registered trials and 12% open enrollment, not the therapeutic-area sidebar.
National Institute of Mental Health (NIMH) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.
Sponsors near 343 trials (± recruiting share)
- Children's Oncology Group · 342 trials · 10% recruiting
- Montefiore Medical Center · 345 trials · 19% recruiting
- Ohio State University Comprehensive Cancer Center · 341 trials · 23% recruiting
- Cedars-Sinai Medical Center · 339 trials · 21% recruiting
Sponsors near 12% open enrollment (± trial volume)
- Augusta University · 12% recruiting · 106 trials
- University of Iowa · 12% recruiting · 228 trials
- Daiichi Sankyo · 12% recruiting · 236 trials
- Friends Research Institute · 12% recruiting · 41 trials
Related
What to do with this National Institute of Mental Health (NIMH) page
343 registered trials is a research-attention snapshot, not an endorsement of National Institute of Mental Health (NIMH) or any single study.
- 42 of National Institute of Mental Health (NIMH)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
- Healthy is the condition National Institute of Mental Health (NIMH) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Healthy trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
National Institute of Mental Health (NIMH) pipeline card: 343 registered trials from official public datasets.Report a data error.