National Institute of Mental Health (NIMH)

343 total trials 42 currently recruiting 256 completed

National Institute of Mental Health (NIMH) sponsors 343 registered US clinical trials on ClinicalTrials.gov, 42 of them currently recruiting, and 256 completed. 29 of these trials are in Phase 3-4 (later-stage) and 106 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 21 trials.

Trial Pipeline

343 total, page 1 of 7

RECRUITING Phase 1

PET Imaging of Noradrenergic Transmission in the Brain

NCT07686393

RECRUITING Phase 1

Evaluation of [11C]ZTP-1 to Image PDE4B

NCT07625345

RECRUITING Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

NCT07169630

RECRUITING Phase 1

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

NCT07027839

RECRUITING Phase 1

PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

NCT06920628

RECRUITING Phase 1

Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers

NCT06874205

RECRUITING Phase 1

PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

NCT06795581

RECRUITING Early Phase 1

Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers

NCT06484088

RECRUITING Phase 2

Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety

NCT06595953

RECRUITING Phase 2

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

NCT06511908

RECRUITING

Natural History of Depression, Bipolar Disorder and Suicide Risk

NCT06462196

RECRUITING Phase 1

Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial

NCT05608434

RECRUITING

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

NCT05669703

RECRUITING NA

State-dependent Interoception, Value-based Decision-making, and Introspection

NCT05666726

RECRUITING Phase 1

[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

NCT05703685

RECRUITING

Developing Brain, Impulsivity and Compulsivity

NCT04631042

RECRUITING NA

Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array

NCT04950309

RECRUITING

Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

NCT04639830

RECRUITING Phase 1

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

NCT04396873

RECRUITING

Long-term Observation of Participants With Mood Disorders

NCT04877977

RECRUITING Phase 1

PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

NCT04582916

RECRUITING NA

Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

NCT04798274

RECRUITING Phase 1

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

NCT03973268

RECRUITING

Characterization and Treatment of Adolescent Depression

NCT03388606

RECRUITING

Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

NCT03304665

RECRUITING Phase 1

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

NCT03065335

RECRUITING Phase 2

Neurobiology of Suicide

NCT02543983

RECRUITING

Psychological Treatments for Youth With Severe Irritability.

NCT02531893

RECRUITING

Brain Stimulation and Vision Testing

NCT01617408

RECRUITING

Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders

NCT01778504

RECRUITING

Top-Down Attentional Control of Visual-Processing

NCT01087281

RECRUITING

A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

NCT01434368

RECRUITING NA

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

NCT01266577

RECRUITING

Defining the Brain Phenotype of Children With Williams Syndrome

NCT01132885

RECRUITING

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

NCT00397111

RECRUITING NA

MRS Measurement of Glutamate and GABA Metabolism in Brain

NCT00109174

RECRUITING

The Neurodevelopmental and Behavioral Phenotyping Screening Protocol

NCT00271622

RECRUITING

Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

NCT00025935

RECRUITING Phase 2

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

NCT00018057

RECRUITING

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

NCT00024635

RECRUITING

Studies of Blood Flow to the Brain During Thought

NCT00001360

RECRUITING

Study of Premenstrual Syndrome and Premenstrual Dysphoria

NCT00001177

ACTIVE NOT RECRUITING NA

Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)

NCT05172271

ACTIVE NOT RECRUITING

Evaluation of the Genetics of Bipolar Disorder

NCT00001174

ACTIVE NOT RECRUITING

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

NCT00001246

NOT YET RECRUITING

Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive Psychotherapy

NCT07640802

NOT YET RECRUITING

Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

NCT07566468

TERMINATED Phase 1

[11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine

NCT05522673

TERMINATED Phase 1

[18F]SF12051 for Imaging the 18-kDa Translocator Protein (TSPO) in Brain and Whole Body of Healthy Subjects

NCT05564429

TERMINATED Phase 2

PET Imaging of Cyclooxygenase in Multiple Sclerosis

NCT05062083

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Phase Distribution

PhaseTrial count
Phase 1 61
Phase 2 45
Phase 3 8
Phase 4 21

What the Pipeline for National Institute of Mental Health (NIMH) Shows

According to the ClinicalTrials.gov registry, National Institute of Mental Health (NIMH) is linked to 343 US clinical trials across every stage of research activity. Of those, 42 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 256 are already marked complete, representing roughly 75% of the total.

The phase mix for National Institute of Mental Health (NIMH) reports 29 late-stage studies (Phase 3 and Phase 4 combined) and 106 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute of Mental Health (NIMH) is Healthy with 21 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.