National Institute of Mental Health (NIMH)

343 total trials 42 currently recruiting 256 completed

National Institute of Mental Health (NIMH) sponsors 343 registered US clinical trials on ClinicalTrials.gov, 42 of them currently recruiting, and 256 completed. 29 of these trials are in Phase 3-4 (later-stage) and 106 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 21 trials.

Trial Pipeline

343 total, page 2 of 7

COMPLETED NA

Identifying Decision Making Parameters in Healthy Volunteers and Anxiety Patients

NCT05092971

COMPLETED

Ask Suicide-Screening Questions (ASQ) for Youth With Autism Spectrum and Neurodevelopmental Disorders

NCT04317118

TERMINATED Phase 2

Antidepressant Effects of TS-161 in Treatment-Resistant Depression

NCT04821271

COMPLETED

Emotional, Social, Cognitive and Behavioral Sequalae of the COVID-19 Pandemic

NCT04823988

COMPLETED Phase 1

Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine

NCT04711005

COMPLETED

Mental Health Impact of the COVID-19 Pandemic on Amish and Mennonite Participants in AMBiGen

NCT04684615

COMPLETED

Impact on Anxiety and Motivation of COVID-19 and Predictors of Individual Responses

NCT04377100

COMPLETED

Mental Health Impact of COVID-19 Pandemic on NIMH Research Participants and Volunteers

NCT04339790

TERMINATED Phase 1

PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel Translocator Protein (TSPO) Radioligand

NCT03958630

TERMINATED Phase 1

Novel PET Radioligand as an Inflammatory Biomarker in Musculoskeletal Conditions

NCT03912428

COMPLETED Phase 2

Estrogen Receptor Beta and Mood

NCT03689543

COMPLETED Phase 1

Title: Evaluation of a Novel PET Radioligand for Phosphodiesterase-4D (PDE4D)

NCT03861000

COMPLETED NA

Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

NCT03289923

COMPLETED Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome

NCT02743377

TERMINATED

Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)

NCT03507218

COMPLETED NA

Development of Non-Invasive Brain Stimulation Techniques

NCT03351764

COMPLETED

Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)

NCT03324646

TERMINATED

Procedures for Sample Acquisition and Distribution for The Human Brain Collection Core

NCT03092687

COMPLETED NA

Effect of Transcranial Magnetic Stimulation to the Frontoparietal Attention Network on Anxiety Potentiated Startle

NCT03027414

TERMINATED Phase 1

Novel Positron Emission Tomography (PET) Radiotracer to Image Phosphodiesterase-4B (PDE4B)

NCT03030391

TERMINATED

Use of the Ask Suicide-Screening Questions (ASQ) in Pediatric Outpatient Settings

NCT02830334

COMPLETED NA

Main Study: Influence on Plasticity of Brain Temperature Sub-Study: Phase Triggered Paired Associative Stimulation (PAS)

NCT02363296

COMPLETED

Evaluation of a Novel PET Radioligand to Image OGA

NCT03632226

COMPLETED Phase 2

Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder

NCT02484456

COMPLETED

Spatial Context and Fear Learning

NCT02423044

COMPLETED

Checking Out Checking In: The Development and Validation of an Electronic Screening Tool for Pediatric Psychosocial Distress

NCT02423031

COMPLETED

PET Imaging in Chronic Traumatic Encephalopathy

NCT02211820

COMPLETED Phase 1

Specific PET Radioligand Binding to Translocator Protein

NCT02181582

COMPLETED Phase 4

Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety

NCT02153944

COMPLETED

Ask Suicide-Screening Questions to Everyone in Medical Settings (asQ em): Development of a Suicide Risk Screening Instrument for Adult Medical Inpatients

NCT02140177

COMPLETED Early Phase 1

Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People

NCT02147392

TERMINATED Phase 1

Evaluation of a Novel Positron Emission Tomography (PET Radiotracer for TARP Gamma-8

NCT02108015

COMPLETED

Imaging and Genetic Investigation of Learning and Decision Making

NCT01950377

TERMINATED

Validation of the Ask Suicide-Screening Questions (ASQ) in the Inpatient Medical Setting

NCT02050867

TERMINATED Phase 1

Does Enhanced Glutamate Transporter Function Produce Antidepressant Effects in People With Major Depression?

NCT02049385

COMPLETED

PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX

NCT02230592

COMPLETED Phase 1

Evaluation of Two Radioactive Chemicals to Image mGluR5 Receptors in Brain

NCT01896843

TERMINATED Phase 2

A Trial of the Drug Donepezil for Sleep Enhancement and Behavioral Change in Children With Autism

NCT01887132

COMPLETED

Brain Inflammation in Major Depressive Disorder Background

NCT01851356

TERMINATED

Effects of Atypical Antipsychotics on Brain Function in Children and Teens With Conduct Disorders

NCT01867398

COMPLETED

Study of [11C]DPA-713 for Temporal Lobe Epilepsy

NCT01793532

COMPLETED

A Pilot Study to Extend the K-SADS-PL to Adolescents and Young Adults

NCT01778478

TERMINATED

Near Infrared Spectroscopy in Children With Autism and ADHD

NCT01730079

TERMINATED Phase 1

Daily Intranasal Oxytocin for Childhood-Onset Schizophrenia

NCT01712646

COMPLETED Phase 1

Translocator Protein and Inflammation After Traumatic Brain Injury

NCT01547780

TERMINATED

Mild Neurocognitive Disorder in HIV Infection of the Brain

NCT01547754

TERMINATED Phase 1

Imaging of Brain Receptors Using (11C)mGlu1

NCT01420952

TERMINATED Phase 1

Imaging of CB1 Receptors Using (11C)SD5024

NCT01399398

COMPLETED

(18F)FCWAY and the Blood-Brain Barrier

NCT01386476

COMPLETED

Study of Toddlers With Language Delay

NCT01339767

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Phase Distribution

PhaseTrial count
Phase 1 61
Phase 2 45
Phase 3 8
Phase 4 21

What the Pipeline for National Institute of Mental Health (NIMH) Shows

According to the ClinicalTrials.gov registry, National Institute of Mental Health (NIMH) is linked to 343 US clinical trials across every stage of research activity. Of those, 42 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 256 are already marked complete, representing roughly 75% of the total.

The phase mix for National Institute of Mental Health (NIMH) reports 29 late-stage studies (Phase 3 and Phase 4 combined) and 106 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute of Mental Health (NIMH) is Healthy with 21 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.