National Heart, Lung, and Blood Institute (NHLBI)

501 total trials 62 currently recruiting 381 completed

National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.

Trial Pipeline

501 total, page 8 of 11

COMPLETED NA

Increasing Physical Activity as Part of a Smoking Cessation Program

NCT00403312

COMPLETED

The Effect of Exercise on Stem Cell Mobilization and Heart Function in Patients Undergoing Cardiac Rehabilitation

NCT00053456

COMPLETED

Identification of Genes Expressed in Atherosclerotic Plaque

NCT00353730

COMPLETED Phase 2

Effects of Nitrite on Blood Vessel Dilation in Normal Volunteers

NCT00048477

COMPLETED Phase 3

Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest

NCT00047411

COMPLETED NA

Acipimox to Improve Hyperlipidemia and Insulin Sensitivity Associated With HIV

NCT00246402

COMPLETED Phase 2

Stem Cell Mobilization to Treat Chest Pain and Shortness of Breath in Patients With Coronary Artery Disease

NCT00043628

COMPLETED Phase 1

Stem Cell Transplant Therapy With Campath-1H for Treating Advanced Mycosis Fungoides and Sezary Syndrome

NCT00047060

COMPLETED

Transfer of GPI-Linked Proteins to Transfused Patients With Paroxysmal Nocturnal Hemoglobinuria

NCT00039923

TERMINATED

Stem Cell Collection for Adult Volunteers

NCT00033774

COMPLETED

Immune Response to Cytomegalovirus

NCT00034437

COMPLETED Phase 2

Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study

NCT00035386

COMPLETED Phase 2

Stem Cell Transplantation and T-Cell Add-Back to Treat Bone Marrow Malignances

NCT00353860

COMPLETED Phase 3

Comparison of Two Programs to Encourage Physical Activity in Individuals With Chronic Obstructive Pulmonary Disease

NCT00328484

COMPLETED Phase 1

Magnetic Resonance Imaging of Narrowed Arteries

NCT00029575

COMPLETED

Possible Relation of Toll-Like Receptors and Nitric Oxide to Chronic Lung Disease

NCT00245167

COMPLETED Phase 1

MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery

NCT00027469

COMPLETED

Technical Development of Cardiovascular Magnetic Resonance Imaging

NCT00027170

COMPLETED

Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease

NCT00012545

COMPLETED

A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study

NCT00340509

COMPLETED NA

Blood and Marrow Transplant Clinical Research Network

NCT00023530

COMPLETED Phase 1

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

NCT00023296

COMPLETED

The Role of Bacteria and Genetic Variations in Cystic Fibrosis

NCT00043225

TERMINATED NA

Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery

NCT00123539

COMPLETED

Tissue Collection From People With Cystic Fibrosis

NCT00015756

COMPLETED Phase 2

Selective T-Cell Depletion to Reduce GVHD (Patients) Receiving Stem Cell Tx to Treat Leukemia, Lymphoma or MDS

NCT00025662

COMPLETED Phase 2

Nitric Oxide Inhalation Therapy to Relieve Chest Pain in Patients With Coronary Artery Disease

NCT00014040

COMPLETED Phase 2

SCH-58235 (Ezetimibe) to Treat Homozygous Sitosterolemia

NCT00045812

COMPLETED

Endothelial Progenitor Cells and Risk Factors for Coronary Artery Disease

NCT00013975

COMPLETED Phase 1

Stem Cell Mobilization Potential in Patients With Aplastic Anemia in Remission

NCT00011830

COMPLETED Phase 2

Pirfenidone to Treat Hypertrophic Cardiomyopathy

NCT00011076

COMPLETED Phase 2

Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia

NCT00011505

COMPLETED

Heart and Skeletal Muscle Problems in Neuroacanthocytosis

NCT00007228

COMPLETED Phase 2

Stem Cell Transplantation to Treat Systemic Mastocytosis

NCT00006413

COMPLETED Phase 2

Phenylbutyrate, Dexamethasone, and Sargramostim in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia

NCT00006240

COMPLETED

Identifying Genes That May Increase the Risk for Heart Disease in African Americans

NCT00344136

COMPLETED

Factors Associated With Coronary Heart Disease in African Americans in the Jackson Heart Study

NCT00415415

COMPLETED NA

Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery

NCT00320619

COMPLETED Phase 3

Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia

NCT00006400

COMPLETED Phase 3

Comparison of Hematocrit Levels in Infant Heart Surgery

NCT00006183

COMPLETED

Effects of Rosiglitazone on Blood Vessels in Patients With High Blood Pressure and High Cholesterol

NCT00006071

COMPLETED Phase 2

Effects of Angiotensin-Converting Enzyme Inhibitor (Ramipril) Therapy on Blood Vessel Inflammation

NCT00005928

COMPLETED

Collection of Liver Tissue for Virologic Studies

NCT00005936

COMPLETED Phase 2

Treatment With Octreotide in Patients With Lymphangioleiomyomatosis

NCT00005906

COMPLETED Phase 2

Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia

NCT00005935

COMPLETED

An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers

NCT00005570

COMPLETED

Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets

NCT00027157

COMPLETED Phase 2

Effects of Hormone Replacement Therapy on Inflammation and Stiffening of Artery Walls

NCT00005108

COMPLETED Phase 2

Combination Therapy of Severe Aplastic Anemia

NCT00001964

COMPLETED NA

School-Based Intervention to Increase Physical Activity Among Adolescent Females

NCT00296101

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 118
Phase 3 29
Phase 4 4

What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows

According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.

The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.