National Heart, Lung, and Blood Institute (NHLBI)

501 total trials 62 currently recruiting 381 completed

National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.

Trial Pipeline

501 total, page 7 of 11

COMPLETED Phase 1

Safety and Dosing Evaluation of REG1 Anticoagulation System

NCT00113997

COMPLETED

Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs)

NCT00119834

COMPLETED

Heart Function and Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

NCT00354328

COMPLETED

Biomarkers for Cardiovascular Disease

NCT00109018

TERMINATED Phase 1

Effect of Nitrite on Exercise Physiology and Metabolism

NCT00105222

TERMINATED

Establishing a Database of People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Data Project [C-Data])

NCT00529061

COMPLETED

Cytokine Gene Polymorphisms in Bone Marrow Failure

NCT00085670

COMPLETED Phase 1

Nitrite Infusion Studies

NCT00102271

COMPLETED Phase 3

Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia

NCT00099996

COMPLETED Phase 3

Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria

NCT00098280

COMPLETED Phase 1

Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease

NCT00095472

COMPLETED Phase 2

Sildenafil to Increase Exercise Capacity in Individuals With Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension

NCT00352482

COMPLETED Phase 1

MRI-Guided Balloon Angioplasty to Treat Blood Flow Blockage in the Legs

NCT00094783

COMPLETED Phase 2

Rosiglitazone to Reverse Metabolic Defects in Diabetes

NCT00094796

COMPLETED

Mutations in Genes Associated With Pentalogy of Cantrell

NCT00083499

COMPLETED

Asthma Surveillance and Education in Preschool Settings

NCT00201071

COMPLETED NA

Work, Weight, and Wellness Program: The 3W Program

NCT00123019

COMPLETED NA

STORIES-Stories to Communicate Risk About Tobacco

NCT00101491

COMPLETED NA

Blood Cell Collection for Future Use in Individuals With Fanconi Anemia

NCT00271089

COMPLETED Phase 2

Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in Patients With Coronary Artery Disease

NCT00090558

COMPLETED NA

Effect of Exercise on Elevated C-reactive Protein Concentrations in Formerly Inactive Adults

NCT00113061

COMPLETED NA

Effects of Exercise Training on Diastolic Heart Function in Postmenopausal Women

NCT00125476

COMPLETED Phase 2

G-CSF and AMD3100 to Mobilize Stem Cells in Healthy Volunteers

NCT00082329

COMPLETED Phase 2

Accelerated Immunization to Induce Cytomegalovirus Immunity in Stem Cell Donors

NCT00353977

COMPLETED

Evaluating the Effects of Hormone Replacement Therapy on Brain Function (The WHIMS-MRI Study)

NCT00739869

COMPLETED

Atherosclerosis in the Coronary and Carotid Arteries

NCT00080587

TERMINATED Phase 2

Thymic Tolerance in Pediatric Heart Transplantation

NCT00151164

COMPLETED Phase 1

EW-A-401 to Treat Intermittent Claudication

NCT00080392

COMPLETED NA

Childhood Asthma Research and Education (CARE) Network Trial - Acute Intervention Management Strategies (AIMS)

NCT00319488

COMPLETED Phase 2

Imatinib (Gleevec(Registered Trademark)) to Treat Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia

NCT00079313

COMPLETED

Technical Development of Strain Rate Echocardiography

NCT00075920

COMPLETED Phase 2

AMD 3100 (Mozobil Plerixafor) to Mobilize Stem Cells for Donation

NCT00075335

COMPLETED Phase 2

Stem Cell Transplantation and T-Cell Add-Back to Treat Bone Marrow Malignancies

NCT00079391

COMPLETED

Cardiac Function in Patients With Hereditary Hemochromatosis

NCT00068159

COMPLETED Phase 3

Stem Cell Transplantation in Individuals With Multiple Myeloma (BMT CTN 0102)

NCT00075829

COMPLETED

The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

NCT00074880

COMPLETED Phase 2

Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia

NCT00065260

COMPLETED Phase 2

A Randomized Trial of Recombinant Humanized Anti-IL-2 Receptor Antibody (Daclizumab) Versus Antithymocyte Globulin (ATG) to Treat the Cytopenia of Myelodysplastic Syndrome (MDS)

NCT00072969

COMPLETED Phase 3

Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study)

NCT00542178

COMPLETED Phase 2

Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease

NCT00069654

COMPLETED NA

Treatment of Persistent Wheezing in Infants and Children

NCT00301171

COMPLETED Phase 3

Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network

NCT00113087

COMPLETED Phase 1

Technical Development of Cardiovascular Magnetic Resonance Imaging

NCT00064896

COMPLETED Phase 2

Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes

NCT00064727

COMPLETED Phase 2

Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia

NCT00061360

COMPLETED

The Framingham Study: Examining DNA Markers and Links to Diseases

NCT00062777

COMPLETED

Investigating Cytokine Genes of Stem Cell Donors

NCT00353821

COMPLETED

Natural History Study for BEN

NCT00059423

COMPLETED Phase 2

Experimental Bone Marrow Transplant Protocol

NCT00061581

COMPLETED

Collection of Biological Samples From Patients With Hepatitis-Associated Aplastic Anemia

NCT00050115

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 118
Phase 3 29
Phase 4 4

What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows

According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.

The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.