National Heart, Lung, and Blood Institute (NHLBI)
National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.
Trial Pipeline
501 total, page 7 of 11
Safety and Dosing Evaluation of REG1 Anticoagulation System
NCT00113997
Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs)
NCT00119834
Heart Function and Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
NCT00354328
Biomarkers for Cardiovascular Disease
NCT00109018
Effect of Nitrite on Exercise Physiology and Metabolism
NCT00105222
Establishing a Database of People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Data Project [C-Data])
NCT00529061
Cytokine Gene Polymorphisms in Bone Marrow Failure
NCT00085670
Nitrite Infusion Studies
NCT00102271
Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia
NCT00099996
Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria
NCT00098280
Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease
NCT00095472
Sildenafil to Increase Exercise Capacity in Individuals With Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension
NCT00352482
MRI-Guided Balloon Angioplasty to Treat Blood Flow Blockage in the Legs
NCT00094783
Rosiglitazone to Reverse Metabolic Defects in Diabetes
NCT00094796
Mutations in Genes Associated With Pentalogy of Cantrell
NCT00083499
Asthma Surveillance and Education in Preschool Settings
NCT00201071
Work, Weight, and Wellness Program: The 3W Program
NCT00123019
STORIES-Stories to Communicate Risk About Tobacco
NCT00101491
Blood Cell Collection for Future Use in Individuals With Fanconi Anemia
NCT00271089
Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in Patients With Coronary Artery Disease
NCT00090558
Effect of Exercise on Elevated C-reactive Protein Concentrations in Formerly Inactive Adults
NCT00113061
Effects of Exercise Training on Diastolic Heart Function in Postmenopausal Women
NCT00125476
G-CSF and AMD3100 to Mobilize Stem Cells in Healthy Volunteers
NCT00082329
Accelerated Immunization to Induce Cytomegalovirus Immunity in Stem Cell Donors
NCT00353977
Evaluating the Effects of Hormone Replacement Therapy on Brain Function (The WHIMS-MRI Study)
NCT00739869
Atherosclerosis in the Coronary and Carotid Arteries
NCT00080587
Thymic Tolerance in Pediatric Heart Transplantation
NCT00151164
EW-A-401 to Treat Intermittent Claudication
NCT00080392
Childhood Asthma Research and Education (CARE) Network Trial - Acute Intervention Management Strategies (AIMS)
NCT00319488
Imatinib (Gleevec(Registered Trademark)) to Treat Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia
NCT00079313
Technical Development of Strain Rate Echocardiography
NCT00075920
AMD 3100 (Mozobil Plerixafor) to Mobilize Stem Cells for Donation
NCT00075335
Stem Cell Transplantation and T-Cell Add-Back to Treat Bone Marrow Malignancies
NCT00079391
Cardiac Function in Patients With Hereditary Hemochromatosis
NCT00068159
Stem Cell Transplantation in Individuals With Multiple Myeloma (BMT CTN 0102)
NCT00075829
The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
NCT00074880
Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia
NCT00065260
A Randomized Trial of Recombinant Humanized Anti-IL-2 Receptor Antibody (Daclizumab) Versus Antithymocyte Globulin (ATG) to Treat the Cytopenia of Myelodysplastic Syndrome (MDS)
NCT00072969
Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study)
NCT00542178
Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease
NCT00069654
Treatment of Persistent Wheezing in Infants and Children
NCT00301171
Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network
NCT00113087
Technical Development of Cardiovascular Magnetic Resonance Imaging
NCT00064896
Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes
NCT00064727
Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia
NCT00061360
The Framingham Study: Examining DNA Markers and Links to Diseases
NCT00062777
Investigating Cytokine Genes of Stem Cell Donors
NCT00353821
Natural History Study for BEN
NCT00059423
Experimental Bone Marrow Transplant Protocol
NCT00061581
Collection of Biological Samples From Patients With Hepatitis-Associated Aplastic Anemia
NCT00050115
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 87 |
| Phase 2 | 118 |
| Phase 3 | 29 |
| Phase 4 | 4 |
Therapeutic Areas
What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows
According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.
The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.