National Heart, Lung, and Blood Institute (NHLBI)
National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.
Trial Pipeline
501 total, page 3 of 11
COV2Base-A Rare Disease by COVID Study
NCT04564274
Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait
NCT04349189
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
NCT04271735
Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT04209621
Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy
NCT04436367
Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy
NCT04436380
Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy
NCT03958643
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome
NCT03789175
HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's-Tyrosine Kinase Inhibitor (BTK-I)
NCT03685708
Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I)
NCT03702231
The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects
NCT03565328
Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary Hypertension
NCT03572036
Effectiveness of the Hepatitis B Vaccine Post-Hematopoietic Stem Cell Transplant
NCT03511794
Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Bimarkers and Chest Imaging
NCT03478917
Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation
NCT03381989
Transmural Systems Transcaval Closure Device for Transcaval Access Ports During Transcatheter Aortic Valve Replacement
NCT03432494
Discovery of Sirolimus Sensitive Biomarkers in Blood
NCT03304678
dbGaP Protocol: The Pediatric Cardiac Genetics Consortium (PCGC)
NCT03347214
Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)
NCT03253692
Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT03204188
Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires
NCT03152773
Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients
NCT03226691
Extracellular RNAs in Relation to Cardiometabolic Risk
NCT03225196
RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2
NCT03225183
NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation
NCT03015194
Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults
NCT03043365
Pathophysiology of Acute Pain in Patients With Sickle Cell Disease
NCT03049475
WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)
NCT02692846
Lung Tissue Research Consortium
NCT02988388
Pembrolizumab and Decitabine for Refractory or Relapsed Acute Myeloid Leukemia
NCT02996474
Impact of Elastin Mediated Vascular Stiffness on End Organs
NCT02840448
CADASIL Disease Discovery
NCT02821780
Dendritic Cell/Myeloma Fusion Vaccine for Multiple Myeloma (BMT CTN 1401)
NCT02728102
Study to Evaluate the Effect of Nicotinamide Riboside on Immunity
NCT02812238
The National Myelodysplastic Syndromes (MDS) Study
NCT02775383
Effect of Fasting and Refeeding on T-cell Fate
NCT02719899
CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction
NCT02740699
High Image Matrix CT Reconstruction
NCT02610465
Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults
NCT02514070
Effect of Fasting on the Asthma Inflammasome
NCT02471300
Biomarkers for Personalized Early Assessment of Response During Salvage Chemotherapy in People With Relapsed or Refractory Acute Myeloid Leukemia (PEARL15)
NCT02527447
Allogeneic Hematopoietic Stem Cell Transplantation With Ixazomib for High Risk Multiple Myeloma (BMT CTN 1302)
NCT02440464
Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)
NCT02345850
Hereditary Parkinson s Disease Natural History Protocol
NCT02511015
dbGaP Protocol: Genetic Variants Associated With Pentalogy of Cantrell
NCT02430376
Effects of Niacin Therapy on Lipoprotein Composition and Function
NCT02322203
Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders
NCT02156115
Continued, Long-Term Follow-Up and Lenalidomide Maintenance Therapy for Patients on BMT CTN 0702 Protocol (BMT CTN 07LT)
NCT02322320
Early Treatment of Acute Graft Versus Host Disease With Bone Marrow-Derived Mesenchymal Stem Cells and Corticosteroids
NCT02379442
Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis
NCT02315586
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 87 |
| Phase 2 | 118 |
| Phase 3 | 29 |
| Phase 4 | 4 |
Therapeutic Areas
What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows
According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.
The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.