National Heart, Lung, and Blood Institute (NHLBI)

501 total trials 62 currently recruiting 381 completed

National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.

Trial Pipeline

501 total, page 3 of 11

COMPLETED

COV2Base-A Rare Disease by COVID Study

NCT04564274

COMPLETED

Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait

NCT04349189

COMPLETED NA

Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis

NCT04271735

TERMINATED Phase 2

Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

NCT04209621

COMPLETED

Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy

NCT04436367

COMPLETED

Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy

NCT04436380

COMPLETED

Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy

NCT03958643

COMPLETED Phase 1

Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

NCT03789175

COMPLETED Phase 2

HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's-Tyrosine Kinase Inhibitor (BTK-I)

NCT03685708

COMPLETED Phase 2

Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I)

NCT03702231

TERMINATED Phase 2

The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

NCT03565328

COMPLETED

Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary Hypertension

NCT03572036

COMPLETED

Effectiveness of the Hepatitis B Vaccine Post-Hematopoietic Stem Cell Transplant

NCT03511794

COMPLETED

Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Bimarkers and Chest Imaging

NCT03478917

COMPLETED NA

Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation

NCT03381989

TERMINATED NA

Transmural Systems Transcaval Closure Device for Transcaval Access Ports During Transcatheter Aortic Valve Replacement

NCT03432494

COMPLETED Phase 2

Discovery of Sirolimus Sensitive Biomarkers in Blood

NCT03304678

COMPLETED

dbGaP Protocol: The Pediatric Cardiac Genetics Consortium (PCGC)

NCT03347214

COMPLETED

Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)

NCT03253692

COMPLETED Phase 2

Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

NCT03204188

COMPLETED NA

Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

NCT03152773

COMPLETED Phase 1

Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients

NCT03226691

COMPLETED

Extracellular RNAs in Relation to Cardiometabolic Risk

NCT03225196

COMPLETED

RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2

NCT03225183

COMPLETED NA

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

NCT03015194

COMPLETED Phase 2

Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults

NCT03043365

COMPLETED

Pathophysiology of Acute Pain in Patients With Sickle Cell Disease

NCT03049475

COMPLETED

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

NCT02692846

COMPLETED

Lung Tissue Research Consortium

NCT02988388

COMPLETED Phase 1

Pembrolizumab and Decitabine for Refractory or Relapsed Acute Myeloid Leukemia

NCT02996474

COMPLETED

Impact of Elastin Mediated Vascular Stiffness on End Organs

NCT02840448

COMPLETED

CADASIL Disease Discovery

NCT02821780

COMPLETED Phase 2

Dendritic Cell/Myeloma Fusion Vaccine for Multiple Myeloma (BMT CTN 1401)

NCT02728102

COMPLETED NA

Study to Evaluate the Effect of Nicotinamide Riboside on Immunity

NCT02812238

COMPLETED

The National Myelodysplastic Syndromes (MDS) Study

NCT02775383

COMPLETED

Effect of Fasting and Refeeding on T-cell Fate

NCT02719899

TERMINATED Phase 4

CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction

NCT02740699

COMPLETED

High Image Matrix CT Reconstruction

NCT02610465

COMPLETED Phase 2

Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults

NCT02514070

COMPLETED

Effect of Fasting on the Asthma Inflammasome

NCT02471300

COMPLETED

Biomarkers for Personalized Early Assessment of Response During Salvage Chemotherapy in People With Relapsed or Refractory Acute Myeloid Leukemia (PEARL15)

NCT02527447

COMPLETED Phase 2

Allogeneic Hematopoietic Stem Cell Transplantation With Ixazomib for High Risk Multiple Myeloma (BMT CTN 1302)

NCT02440464

COMPLETED Phase 3

Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

NCT02345850

COMPLETED

Hereditary Parkinson s Disease Natural History Protocol

NCT02511015

COMPLETED

dbGaP Protocol: Genetic Variants Associated With Pentalogy of Cantrell

NCT02430376

COMPLETED NA

Effects of Niacin Therapy on Lipoprotein Composition and Function

NCT02322203

TERMINATED

Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders

NCT02156115

COMPLETED Phase 3

Continued, Long-Term Follow-Up and Lenalidomide Maintenance Therapy for Patients on BMT CTN 0702 Protocol (BMT CTN 07LT)

NCT02322320

TERMINATED Phase 1

Early Treatment of Acute Graft Versus Host Disease With Bone Marrow-Derived Mesenchymal Stem Cells and Corticosteroids

NCT02379442

COMPLETED

Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis

NCT02315586

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 118
Phase 3 29
Phase 4 4

What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows

According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.

The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.