National Heart, Lung, and Blood Institute (NHLBI)

501 total trials 62 currently recruiting 381 completed

National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.

Trial Pipeline

501 total, page 2 of 11

RECRUITING

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

NCT00923507

RECRUITING

Collection of Lung Fluid and Tissue Samples for Research

NCT00471250

RECRUITING

Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

NCT00442195

RECRUITING

Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants

NCT00106925

RECRUITING

Natural History of Sickle Cell Disease

NCT00081523

RECRUITING

Genetic Basis of Immunodeficiency

NCT00055172

RECRUITING

Causes and Natural History of Dyslipidemias

NCT00353782

RECRUITING

Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members

NCT00071045

RECRUITING

Study of Skin Tumors in Tuberous Sclerosis

NCT00001975

RECRUITING

Role of Genetic Factors in the Development of Lung Disease

NCT00001532

RECRUITING

Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives

NCT00001529

RECRUITING

Study of the Disease Process of Lymphangioleiomyomatosis

NCT00001465

ACTIVE NOT RECRUITING Phase 1

Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome

NCT06676033

ACTIVE NOT RECRUITING

Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease

NCT05675436

ACTIVE NOT RECRUITING Phase 1

Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function

NCT06145282

ACTIVE NOT RECRUITING Phase 1

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

NCT05357482

ACTIVE NOT RECRUITING Phase 1

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

NCT04610866

ACTIVE NOT RECRUITING NA

NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study

NCT03929913

ACTIVE NOT RECRUITING Phase 2

Eltrombopag for People With Fanconi Anemia

NCT03206086

ACTIVE NOT RECRUITING Phase 1

HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

NCT03354390

ACTIVE NOT RECRUITING Phase 1

Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

NCT03077542

ACTIVE NOT RECRUITING Phase 2

Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

NCT02979873

ACTIVE NOT RECRUITING Phase 2

A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL

NCT02514083

ACTIVE NOT RECRUITING Phase 2

Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

NCT02105766

ACTIVE NOT RECRUITING Phase 1

Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

NCT01623167

ACTIVE NOT RECRUITING Phase 2

PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT01500733

ACTIVE NOT RECRUITING Phase 2

Eltrombopag for Moderate Aplastic Anemia

NCT01328587

ACTIVE NOT RECRUITING Phase 1

Haploidentical PBMC Transplant for Severe Congenital Anemias

NCT00977691

ACTIVE NOT RECRUITING

Hispanic Community Health Study / Study of Latinos

NCT02060344

ACTIVE NOT RECRUITING

The Jackson Heart Study of Cardiovascular Disease Among African Americans

NCT00005485

ACTIVE NOT RECRUITING

Cardiovascular Health Study (CHS)

NCT00005133

NOT YET RECRUITING Phase 1

Syk Inhibition in MItigating Lung Allograft Rejection (SIMILAR): A Trial to Evaluate the Safety and Tolerability of Fostamatinib in Lung Transplant Patients With Donor-Specific Antibodies

NCT06948097

NOT YET RECRUITING Phase 3

Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging

NCT07613099

NOT YET RECRUITING

NHLBI-Emory Advanced Cardiac CT Reconstruction

NCT05372627

TERMINATED NA

NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study

NCT06269640

COMPLETED Phase 1

JAK/STAT Inhibition in CNS Kohlmeier-Degos Disease

NCT05998395

COMPLETED Phase 1

Study of the Selective GlyT1 Inhibitor Bitopertin for Steroid-Refractory Diamond-Blackfan Anemia

NCT05828108

TERMINATED Phase 2

Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated Cytopenias

NCT05502783

COMPLETED NA

NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial

NCT05666713

COMPLETED

Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD)

NCT05604547

COMPLETED Early Phase 1

Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens Into the Human Lung

NCT05027958

COMPLETED

Anti-Inflammatory Effects of Time-Restricted Feeding

NCT04728165

TERMINATED

Effect of Chronic Inflammation on Myocardial Perfusion and Function

NCT04870827

COMPLETED

Gene First Approach to Connective Tissue Disease

NCT04664478

COMPLETED Early Phase 1

Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease

NCT04476277

COMPLETED NA

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African Americans Study (GENE-FORECAST): Sodium Intervention Trial (SIT)

NCT04717336

COMPLETED Phase 1

Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag

NCT04269889

COMPLETED Phase 2

Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease

NCT04514510

COMPLETED

Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)

NCT04603521

COMPLETED Phase 2

Fostamatinib for Hospitalized Adults With COVID-19

NCT04579393

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 118
Phase 3 29
Phase 4 4

What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows

According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.

The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.