National Heart, Lung, and Blood Institute (NHLBI)

501 total trials 62 currently recruiting 381 completed

National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.

Trial Pipeline

501 total, page 4 of 11

COMPLETED

Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)

NCT02303067

COMPLETED

Genes Involved in Lipid Disorders

NCT02311335

COMPLETED Phase 2

Complement Inhibition Using Eculizumab to Overcome Platelet Transfusion Refractoriness in Patients With Severe Thrombocytopenia

NCT02298933

COMPLETED

Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

NCT02290392

COMPLETED Phase 1

Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access

NCT02280824

COMPLETED

Clinical Outcomes and Molecular Phenotypes in Smokers With Parenchymal Lung Disease

NCT02055222

TERMINATED Phase 1

Phase I/II Trial of Early Infusion of Rapidly-generated Multivirus Specific T Cells (MVST) to Prevent Post Transplant Viral Infections

NCT02231853

COMPLETED Phase 1

Ultra-Low Dose IL-2 Therapy as GVHD Prophylaxis in Haploidentical Allogeneic Stem Cell Transplantation

NCT02226861

COMPLETED Phase 1

Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease

NCT02225132

COMPLETED Phase 2

Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

NCT02208037

COMPLETED

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

NCT02055209

COMPLETED

Effect of Fasting on the NLRP3 Inflammasome

NCT02122575

COMPLETED

Links Between Inflammation and Cardiometabolic Diseases

NCT01934660

COMPLETED Phase 2

Extended Dosing With Eltrombopag for Severe Aplastic Anemia

NCT01891994

COMPLETED Phase 1

Preventing Stem Cell Transplant Complications With a Blood Separator Machine

NCT01866839

COMPLETED Phase 1

Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals

NCT01862029

COMPLETED

Pilot Study of Strength Testing in Overweight Women With or Without Insulin Resistance

NCT01862757

COMPLETED

Medical Arm of the Interagency Registry for Mechanically Assisted Circulatory Support

NCT01932294

COMPLETED

Longitudinal Observational Study of Severe Asthma

NCT01780142

COMPLETED

Intravenous ACP-501 for Familial LCAT Deficiency (rhLCAT)

NCT04737720

COMPLETED

The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)

NCT01778569

TERMINATED

Myocardial Perfusion and Scarring in Congenital Heart Disease

NCT01639937

COMPLETED

Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) Follow-up Observational Study II Protocol

NCT01783990

COMPLETED Phase 2

Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)

NCT01585402

COMPLETED

Genetics and Pain Severity in Sickle Cell Disease

NCT01441141

COMPLETED Phase 1

Clofarabine Followed By Lenalidomide for High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia

NCT01629082

COMPLETED

Microvessels and Heart Problems in Sickle Cell Disease

NCT01602809

COMPLETED

Blood Flow and Pain Crises in People With Sickle Cell Disease

NCT01568710

COMPLETED Phase 2

Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans

NCT01273207

COMPLETED Phase 2

Hemoglobin and Iron Recovery Study

NCT01555060

TERMINATED Phase 1

Stem Cell Injection to Treat Heart Damage During Open Heart Surgery

NCT01557543

TERMINATED

Mutations Associated With Parkinson s Disease

NCT01547832

TERMINATED

Heart Imaging in Children With Muscular Dystrophy

NCT01633242

COMPLETED

Carbon Monoxide Levels and Sickle Cell Disease Severity

NCT01547793

COMPLETED Phase 1

Improving Blood Stem Cell Collection and Transplant Procedures

NCT01517035

COMPLETED Phase 1

Bone Marrow Stromal Cell Infusions for Stem Cell Transplant Complications

NCT01633229

TERMINATED Phase 1

Pericardiocentesis With Magnetic Resonance Imaging

NCT01479569

COMPLETED Phase 1

Ultra Low Dose Interleukin-2 in Healthy Volunteers

NCT01445561

TERMINATED

Ultrasound and Other Images of Artery Blockages

NCT01419574

COMPLETED Phase 1

Danazol for Genetic Bone Marrow and Lung Disorders

NCT01441037

COMPLETED Phase 2

Decitabine for High-Risk Sickle Cell Disease

NCT01375608

COMPLETED

Cross-sectional Characterization of Idiopathic Bronchiectasis

NCT01264055

COMPLETED Phase 2

A Pilot Study of a Thrombopoietin-Receptor Agonist, Eltrombopag, in Patients With Low to Int-2 Risk Myelodysplastic Syndrome (MDS)

NCT00961064

COMPLETED Phase 1

Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders

NCT01316796

COMPLETED Phase 1

Real-time MRI Right Heart Catheterization Using Passive Catheters

NCT01287026

COMPLETED Phase 2

Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Syndrome

NCT01287078

COMPLETED

Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers

NCT01281995

COMPLETED NA

Systolic Blood Pressure Intervention Trial

NCT01206062

COMPLETED Phase 4

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

NCT01212900

COMPLETED Phase 1

Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia

NCT01193283

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 118
Phase 3 29
Phase 4 4

What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows

According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.

The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.