National Heart, Lung, and Blood Institute (NHLBI)
National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.
Trial Pipeline
501 total, page 4 of 11
Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)
NCT02303067
Genes Involved in Lipid Disorders
NCT02311335
Complement Inhibition Using Eculizumab to Overcome Platelet Transfusion Refractoriness in Patients With Severe Thrombocytopenia
NCT02298933
Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0
NCT02290392
Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access
NCT02280824
Clinical Outcomes and Molecular Phenotypes in Smokers With Parenchymal Lung Disease
NCT02055222
Phase I/II Trial of Early Infusion of Rapidly-generated Multivirus Specific T Cells (MVST) to Prevent Post Transplant Viral Infections
NCT02231853
Ultra-Low Dose IL-2 Therapy as GVHD Prophylaxis in Haploidentical Allogeneic Stem Cell Transplantation
NCT02226861
Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease
NCT02225132
Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)
NCT02208037
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)
NCT02055209
Effect of Fasting on the NLRP3 Inflammasome
NCT02122575
Links Between Inflammation and Cardiometabolic Diseases
NCT01934660
Extended Dosing With Eltrombopag for Severe Aplastic Anemia
NCT01891994
Preventing Stem Cell Transplant Complications With a Blood Separator Machine
NCT01866839
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals
NCT01862029
Pilot Study of Strength Testing in Overweight Women With or Without Insulin Resistance
NCT01862757
Medical Arm of the Interagency Registry for Mechanically Assisted Circulatory Support
NCT01932294
Longitudinal Observational Study of Severe Asthma
NCT01780142
Intravenous ACP-501 for Familial LCAT Deficiency (rhLCAT)
NCT04737720
The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)
NCT01778569
Myocardial Perfusion and Scarring in Congenital Heart Disease
NCT01639937
Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) Follow-up Observational Study II Protocol
NCT01783990
Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)
NCT01585402
Genetics and Pain Severity in Sickle Cell Disease
NCT01441141
Clofarabine Followed By Lenalidomide for High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia
NCT01629082
Microvessels and Heart Problems in Sickle Cell Disease
NCT01602809
Blood Flow and Pain Crises in People With Sickle Cell Disease
NCT01568710
Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans
NCT01273207
Hemoglobin and Iron Recovery Study
NCT01555060
Stem Cell Injection to Treat Heart Damage During Open Heart Surgery
NCT01557543
Mutations Associated With Parkinson s Disease
NCT01547832
Heart Imaging in Children With Muscular Dystrophy
NCT01633242
Carbon Monoxide Levels and Sickle Cell Disease Severity
NCT01547793
Improving Blood Stem Cell Collection and Transplant Procedures
NCT01517035
Bone Marrow Stromal Cell Infusions for Stem Cell Transplant Complications
NCT01633229
Pericardiocentesis With Magnetic Resonance Imaging
NCT01479569
Ultra Low Dose Interleukin-2 in Healthy Volunteers
NCT01445561
Ultrasound and Other Images of Artery Blockages
NCT01419574
Danazol for Genetic Bone Marrow and Lung Disorders
NCT01441037
Decitabine for High-Risk Sickle Cell Disease
NCT01375608
Cross-sectional Characterization of Idiopathic Bronchiectasis
NCT01264055
A Pilot Study of a Thrombopoietin-Receptor Agonist, Eltrombopag, in Patients With Low to Int-2 Risk Myelodysplastic Syndrome (MDS)
NCT00961064
Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders
NCT01316796
Real-time MRI Right Heart Catheterization Using Passive Catheters
NCT01287026
Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Syndrome
NCT01287078
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers
NCT01281995
Systolic Blood Pressure Intervention Trial
NCT01206062
Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
NCT01212900
Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia
NCT01193283
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 87 |
| Phase 2 | 118 |
| Phase 3 | 29 |
| Phase 4 | 4 |
Therapeutic Areas
What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows
According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.
The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.