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NCT02740699 · ClinicalTrials.gov registry record · Phase 4
CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction
A Phase 4 study, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
- Terminated
- Registry status
- Phase 4
- Development phase
- 79
- Enrollment target
NCT02740699: Clinical Trial Phase 4 study, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
NCT02740699 is a Phase 4 study that was terminated before completion, run by National Heart, Lung, and Blood Institute (NHLBI). The registered enrollment target is 79 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02740699, a Phase 4 study, was terminated before completion, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 79 participants
- Enrollment target
Study Summary
Background: Coronary artery disease causes plaque in arteries. This can cause stroke or heart disease. Drugs called statins might shrink plaque. Researchers want to study how CT scanning can determine if an individuals arterial plaque has decreased while taking statins. Objectives: To measure the change in coronary artery plaque volume in people treated with high-intensity statin therapy using CT and MRI scans. To study the metabolic activity of plaque in arteries. To determine how well plaque measurements from heart CT scans can be replicated. Eligibility: Men ages 40-75 and women ages 40-75 who are good candidates for statin treatment Design: Visit 1: participants will be screened with: * Medical history * Blood tests * Heart MRI and CT scan: An IV inserted into an arm or hand vein removes blood and injects contrast, and medicine if needed. Participants lie on a table that slides into a machine that takes pictures of the body. For the CT scan, if their heart rate is too high, they get medicine to lower it. They breathe in a special way, holding their breath for 5 seconds. Participants will begin high-intensity statin treatment. Participants will have 7 more visits over 3 years. All visits include blood tests and medication review. Some may also include: * Statin treatment adjustment * CT scan * MRI scan * Physical exam Participants may join the PET Substudy. This includes 5 more visits during the study. These include: * Getting an IV in an arm vein * Blood tests * PET scans: They fast 12 hours before. Participants may join the Reproducibility Substudy if they had a slow heart rate during their first CT scan. This includes 1 additional heart CT scan 4 weeks later.
Primary Outcome
Mean change of non-calcified plaque volume assessed by Coronary computed tomography angiography in participants treated with high intensity statin therapy (as defined by the 2013 ACC/AHA Guidelines to Reduce Cardiovascular Risk (GRCR). Using anatomical landmarks, a target plaque volume will be defined at baseline and follow up examinations. Software will be used to trace lumen and outer vessel boundaries to determine non-calcified plaque volume. The 2013 ACC/AHA Guidelines to GRCR focuses on t
Interventions
- DRUG Rosuvastatin
- DRUG Atorvastatin
- RADIATION Cardiac Computed Tomography (CT)
- RADIATION Cardiac Magnetic Resonance Image (MRI)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 79 participants |
| Start Date | 2016-04-11 |
| Est. Completion | 2022-03-11 |
| Phase | Phase 4 |
Why NCT02740699 stopped before completion
NCT02740699 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 79 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 4 interventions - of which Rosuvastatin is the first listed.
NCT02740699 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02740699 about?
NCT02740699 is a clinical study titled "CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction". Background: Coronary artery disease causes plaque in arteries. This can cause stroke or heart disease. Drugs called statins might shrink plaque. Researchers want to study how CT scanning can determine if an individuals arterial plaque has decreased while taking statins. Objectives: To measure the...
What is the current status of trial NCT02740699?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 79 participants. The study started on 2016-04-11. Estimated completion is 2022-03-11.
What interventions are being tested in trial NCT02740699?
The interventions under investigation include: Rosuvastatin (DRUG), Atorvastatin (DRUG), Cardiac Computed Tomography (CT) (RADIATION), Cardiac Magnetic Resonance Image (MRI) (RADIATION).
Who is sponsoring clinical trial NCT02740699?
This trial is sponsored by National Heart, Lung, and Blood Institute (NHLBI), which has 501 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02740699's enrollment target sits among peer trials
79 980th of 2000 higher than 1,019 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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