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NCT02840448 · ClinicalTrials.gov registry record
Impact of Elastin Mediated Vascular Stiffness on End Organs
A clinical trial, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
- Completed
- Registry status
- 159
- Enrollment target
NCT02840448: Completed study, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
NCT02840448 is a clinical trial that has completed, run by National Heart, Lung, and Blood Institute (NHLBI). The registered enrollment target is 159 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02840448 has completed, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
- COMPLETED
- Registry status
- 159 participants
- Enrollment target
Study Summary
Background: People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness. Blood vessels may have focal narrowings called stenoses or may just be globally more narrow. Objectives: Researchers want to see how blood vessel differences in people with Williams Syndrome and supravalvular aortic stenosis affect organs in the body including the heart, gut, kidneys, and brain. Eligibility: People ages 3-85 who have WS or SVAS Healthy volunteers ages 3-85 Design: * Participants will have yearly visits for up to 10 years. All participants will be offered the same tests. * Participants will give consent for the study team to review their medical records. If the participant is a child or an adult with WS, a parent or guardian will give the consent. * Participants will visit the NIH where they will have a physical exam and medical history. Based on their health history, participants will undergo a series of imaging tests and measures of blood vessel function over the course of 2-4 days. Tests of cognitive abilites will also be performed. Blood will be drawn and an IV may be placed for specific tests.
Primary Outcome
Pilot studies aimed at identifying differences between the WS/SVAS/WS gene region variation population and controls.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 159 participants |
| Start Date | 2016-12-02 |
| Est. Completion | 2024-04-06 |
What the finished NCT02840448 record still lists
NCT02840448 is an observational study that tracks outcomes without assigning an intervention. The registered 159 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT02840448 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02840448 about?
NCT02840448 is a clinical study titled "Impact of Elastin Mediated Vascular Stiffness on End Organs". Background: People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness. Blood vessels may have focal narrowings called stenoses or may just be globally more narrow. Objectives: Researchers want to ...
What is the current status of trial NCT02840448?
This trial is currently completed. The enrollment target is 159 participants. The study started on 2016-12-02. Estimated completion is 2024-04-06.
Who is sponsoring clinical trial NCT02840448?
This trial is sponsored by National Heart, Lung, and Blood Institute (NHLBI), which has 501 total clinical trials registered on ClinicalTrials.gov.
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