National Eye Institute (NEI)
National Eye Institute (NEI) sponsors 221 registered US clinical trials on ClinicalTrials.gov, 18 of them currently recruiting, and 179 completed. 11 of these trials are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Age-related Macular Degeneration, with 8 trials.
Trial Pipeline
221 total, page 1 of 5
National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases
NCT06491615
Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
NCT04289571
Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4
NCT04591483
Oral Metformin for Treatment of ABCA4 Retinopathy
NCT04545736
Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration
NCT04339764
Perception, Sensation, Cognition and Action in Humans
NCT03407066
Clinical and Molecular Studies in Families With Inherited Eye Disease
NCT02771236
Natural History, Pathogenesis, and Outcome of Ocular Disorders
NCT02821767
Natural History of Spinocerebellar Ataxia Type 7 (SCA7)
NCT02741440
Rod and Cone Mediated Function in Retinal Disease
NCT02617966
Genetics of Inherited Eye Disease
NCT02471287
Adaptive Optics Retinal Imaging
NCT02317328
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions
NCT02077894
Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma (MAC)
NCT01778543
National Eye Institute Biorepository for Retinal Diseases
NCT01496625
Cell Collection to Study Eye Diseases
NCT01432847
Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene
NCT01145196
Screening for Research Participants
NCT00655096
Training to Modify Fixational Eye Movements for Optimizing Visual Performance in People With Central Vision Loss
NCT06670989
Retrospective Case Series of Trans-scleral Cryotherapy for Retinal Hemangioblastoma
NCT04458935
Dark Adaptation in Participants With Age-Related Macular Degeneration
NCT03225131
Natural History of Eye Diseases Related to ABCA4 Mutations
NCT01736293
Study of Dark Adaptation in Age-Related Macular Degeneration
NCT01352975
Age-Related Eye Disease Study (AREDS) Follow-Up
NCT00594672
Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis
NCT00055029
Potential Environmental Causes of Uveal Coloboma
NCT04833361
Ocular Findings and Viral Persistence in Ocular Fluids in COVID-19 Survivors
NCT04665752
Biomarkers in Ocular Inflammation and Uveitis
NCT04690829
Retinitis Pigmentosa Clinical Measures and Repeatability Testing of Potential Outcome Measures
NCT03845218
Generation of Induced Pluripotent Stem (iPS) Cell Lines From Skin Fibroblast Cells of Participants With Age-Related Macular Degeneration
NCT03372746
Age-Related Eye Disease Study 2 (AREDS2) 10-year Follow-On
NCT03367767
Vitamin A Palmitate Supplementation in Patients With Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation
NCT03478878
Vitamin A Palmitate Supplementation in People With Age-Related Macular Degeneration (and Without Reticular Pseudodrusen) and Delayed Dark Adaptation
NCT03478865
AMD Ryan Initiative Study (ARIS)
NCT03092492
Mothers Experiences With X-linked Retinoschisis Compared to Fathers Experiences
NCT03354403
Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening Uveitis (STAR Study)
NCT02911116
Natural History of Geographic Atrophy Associated With Age-Related Macular Degeneration
NCT02941263
A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab
NCT02859441
Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration
NCT02564978
Uveitis/Intraocular Inflammatory Disease Biobank (iBank)
NCT02656381
The Focal Electro-Oculogram in Macular Disease
NCT02225119
Interferon Gamma-1b Administered Topically for Macular Edema/Intraretinal Schisis Cysts in Rod-Cone Dystrophy (RCD) and Enhanced S-Cone Syndrome (ESCS)
NCT02338973
People s Expectations When Enrolling in a Phase I/II RS1 Ocular Gene Transfer Clinical Trial
NCT02317354
Study of Retinal Findings in People With Signs and Symptoms of Alzheimer s Disease Enrolled in 09-M-0198
NCT02226835
Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa
NCT02140164
A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients
NCT01972438
Intestinal Bacteria and Ocular Inflammatory Disease
NCT01859299
Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study
NCT01915238
Color Vision as a Measure for Inherited Retinal Diseases
NCT01878032
Nitisinone for Type 1B Oculocutaneous Albinism
NCT01838655
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 62 |
| Phase 2 | 24 |
| Phase 3 | 11 |
Therapeutic Areas
What the Pipeline for National Eye Institute (NEI) Shows
According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 221 US clinical trials across every stage of research activity. Of those, 18 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 179 are already marked complete, representing roughly 81% of the total.
The phase mix for National Eye Institute (NEI) reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 86 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-related Macular Degeneration with 8 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.