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NCT00647439 · ClinicalTrials.gov registry record
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
A clinical trial of Diabetic Retinopathy and Uveitis, sponsored by National Eye Institute (NEI).
- Completed
- Registry status
- 609
- Enrollment target
- 1
- Study location
NCT00647439: Completed study of Diabetic Retinopathy and Uveitis, sponsored by National Eye Institute (NEI).
NCT00647439 is a study of Diabetic Retinopathy and Uveitis that has completed, run by National Eye Institute (NEI). The registered enrollment target is 609 participants, below the 1,666-participant average among 57 other Diabetic Retinopathy trials with a reported enrollment target (63% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00647439, a study of Diabetic Retinopathy and Uveitis, has completed, sponsored by National Eye Institute (NEI).
- COMPLETED
- Registry status
- 609 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will identify genes that are associated with inflammation or degeneration of the retina (membrane lining the back of the eye that relays vision signals to the brain). It is thought that many retinal conditions are due to an altered immune system and are based on how the person s genes function and communicate. People 4 years of age or older who have a retinal condition such as uveitis, age-related macular degeneration or diabetic retinopathy may be eligible for this study. Healthy volunteers and healthy people who have a family member with one of these conditions are also eligible. Patients with inherited retinal degeneration are excluded. Participants undergo the following tests and procedures: * Eye examination to assess visual acuity (eye chart test) and eye pressure, and to examine the pupils, lenses, retina and eye movements. Photographs of the inside of the eye may also be taken. The pupils are dilated with drops for this examination. * Blood draw for genetic testing. Participants may also undergo one or more of the following tests: * Optical coherence tomography. This is a type of photograph of the back of the eye to measure thickness of the retina. * Fluorescein angiography and indocyanine green angiography. Pictures of the eye s blood vessels are taken using either a fluorescein or indocyanine green dye. The dye is injected into a vein in an arm and travels to the blood vessels in the eyes. A camera takes pictures of the dye as it flows through the blood vessels. * Electroretinogram (ERG) to measure retinal function. The patient sits in a dark room for 30 minutes with his or her eyes patched. Then, a small metal disk electrode is taped to the forehead, the eye patches are removed, the surface of the eye is numbed with eye drops, and contact lenses are placed on the eyes. The patient then watches flashing lights. The contact lenses sense small electrical signals generated by the retina when the light flashes....
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 609 participants |
| Start Date | 2008-03-27 |
| Est. Completion | 2018-12-04 |
What the finished NCT00647439 record still lists
NCT00647439 is an observational study that tracks outcomes without assigning an intervention. The registered 609 participants enrollment target is mid-sized for trials with a published cap, below the 1,666-participant average among 57 other Diabetic Retinopathy trials with a reported enrollment target (63% lower).
The record links to 3 conditions, with Diabetic Retinopathy appearing as the primary indexed condition, and to 0 interventions.
NCT00647439 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00647439 about?
NCT00647439 is a clinical study titled "Genetics and Markers of Degenerative and Inflammatory Eye Diseases". This study will identify genes that are associated with inflammation or degeneration of the retina (membrane lining the back of the eye that relays vision signals to the brain). It is thought that many retinal conditions are due to an altered immune system and are based on how the person s genes fun...
What is the current status of trial NCT00647439?
This trial is currently completed. The enrollment target is 609 participants. The study started on 2008-03-27. Estimated completion is 2018-12-04.
What conditions does trial NCT00647439 study?
This clinical trial studies the following conditions: Diabetic Retinopathy, Uveitis, Age-related Macular Degeneration (AMD).
Who is sponsoring clinical trial NCT00647439?
This trial is sponsored by National Eye Institute (NEI), which has 221 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00647439 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT00647439's enrollment target sits among peer trials
609 14th of 57 higher than 44 of 57 other Diabetic Retinopathy trials
participants (enrollment target), bucketed by value
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