Merck Sharp & Dohme

558 total trials 120 currently recruiting 320 completed

Merck Sharp & Dohme sponsors 558 registered US clinical trials on ClinicalTrials.gov, 120 of them currently recruiting, and 320 completed. 191 of these trials are in Phase 3-4 (later-stage) and 360 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 25 trials.

Trial Pipeline

558 total, page 5 of 12

ACTIVE NOT RECRUITING Phase 2

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

NCT03742895

ACTIVE NOT RECRUITING Phase 3

Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)

NCT03553836

ACTIVE NOT RECRUITING Phase 3

Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

NCT03425643

ACTIVE NOT RECRUITING Phase 2

Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)

NCT03407144

COMPLETED Phase 1

A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017)

NCT07548606

COMPLETED Phase 1

A Clinical Study of Ulonivirine (MK-8507) With Atorvastatin and Metformin in Healthy Adults (MK-8507-018)

NCT07530289

COMPLETED Phase 1

A Clinical Study of the Effect of Enlicitide (MK-0616) Formulations in Healthy Participants (MK-0616-041)

NCT07481708

COMPLETED Phase 1

A Clinical Study of the Effect of MK-2828 on Rosuvastatin or Furosemide in Healthy People (MK-2828-005)

NCT07431866

COMPLETED Phase 1

A Clinical Study of Calderasib (MK-1084) With Rosuvastatin and Metformin in Healthy People (MK-1084-016)

NCT07222098

COMPLETED Phase 1

A Study of Rifabutin and MK-4646 in Healthy Participants (MK-4646-004)

NCT07199452

COMPLETED Phase 1

A Study of Doravirine/Islatravir in Healthy Lactating Females (MK-8591A-061)

NCT07086079

COMPLETED Phase 1

A Clinical Study of MK-8527 in Participants With Mild and Moderate Hepatic Impairment (MK-8527-015)

NCT07025551

COMPLETED Phase 1

A Study of [14C]Ulonivirine ([14C]MK-8507) in Healthy Adults (MK-8507-006)

NCT07334886

COMPLETED Phase 1

A Study of Bomedemstat (MK-3543) in Participants With Mild or Moderate Hepatic Impairment (MK-3543-023)

NCT07049939

COMPLETED Phase 1

A Study of Belzutifan (MK-6482) and Metformin in Healthy Adult Participants (MK-6482-039)

NCT07121959

COMPLETED Phase 1

A Clinical Study of MK-8527 in Healthy Adult Participants (MK-8527-014)

NCT07063238

COMPLETED Phase 1

A Clinical Study of How Coffee and Tea Affect Enlicitide in Healthy Volunteers (MK-0616-040)

NCT07044479

COMPLETED Phase 1

A Study of Sotatercept (MK-7962) in Healthy Females Administered as a Liquid Formulation in an Autoinjector Versus the Lyophilized Formulation (MK-7962-027)

NCT06930664

COMPLETED Phase 1

A Study to Evaluate the Effect of Formulation and Food on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-011)

NCT06942741

COMPLETED Phase 1

A Study to Evaluate Opevesostat (MK-5684) in Male Participants With Moderate Hepatic Impairment (MK-5684-009)

NCT06860243

COMPLETED Phase 1

A Study of Carbamazepine (CBZ) and MK-8527 in Healthy Adult Participants (MK-8527-012)

NCT06893081

COMPLETED Phase 1

A Study of MK-4700 Alone or With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors (MK-4700-001)

NCT06894771

COMPLETED Phase 1

A Study to Evaluate the Effect of MK-5684 in Male Participants With Severe Renal Impairment (RI) and With End-stage Renal Disease (ESRD) (MK-5684-010)

NCT06814132

COMPLETED Phase 1

A Clinical Study of Calderasib (MK-1084) in Participants With Renal Impairment (MK-1084-010)

NCT06814119

COMPLETED Phase 1

A Clinical Study to Evaluate Enlicitide (MK-0616) Formulations in Healthy Adult Participants (MK-0616-035)

NCT06880874

COMPLETED Phase 1

A Clinical Study of Belzutifan (MK-6482) Alone or With Phenytoin in Healthy Participants (CA46602/MK-6482-035)

NCT06903715

COMPLETED Phase 1

A Study of MK-8527 in Healthy Adult Participants (MK-8527-013)

NCT06826989

COMPLETED Phase 1

A Study of the Effect of Multiple Doses of Diltiazem on the Plasma Levels of MK-6916 in Healthy Participants (MK-6916-005)

NCT06818968

COMPLETED Phase 1

A Study of Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) and MK-8527 in Healthy Participants

NCT06816043

COMPLETED Phase 1

A Study of the Effect Efavirenz on the Plasma Levels of MK-7602 in Healthy Participants (MK-7602-005)

NCT06797674

COMPLETED Phase 1

A Study of Lithium and Enlicitide in Healthy Adult Participants (MK-0616-034)

NCT06719544

COMPLETED Phase 1

A Drug-Drug Interaction Study of Carbamazepine and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-012)

NCT06633419

COMPLETED Phase 1

A Clinical Study of Enlicitide in Participants With Severe Renal Impairment (MK-0616-032)

NCT06643377

COMPLETED Phase 2

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)

NCT06664801

COMPLETED Phase 1

A Clinical Study of MK-1708 in Healthy Elderly Participants (MK-1708-005)

NCT06647628

COMPLETED Phase 1

A Clinical Study of Enlicitide and the Effect of Food in Healthy Adult Participants (MK-0616-033)

NCT06609512

COMPLETED Phase 1

A Study of MK-2060 in Healthy Participants (MK-2060-016)

NCT06582602

COMPLETED Phase 1

A Clinical Study to Assess the Effect of Enlicitide on How the Body Processes Digoxin in Healthy Adult Participants (MK-0616-031)

NCT06597760

COMPLETED Phase 1

A Study to Evaluate the Effects of Itraconazole on MK-1708 in Healthy Participants (MK-1708-003)

NCT06586606

COMPLETED Phase 1

Drug-Drug Interaction Study of Bomedemstat and Carbamazepine in Healthy Adult Participants (MK-3543-020)

NCT06596668

COMPLETED Phase 1

A Study of V118 Formulation C (V118C) in Healthy Participants (V118C-001)

NCT06611033

COMPLETED Phase 1

Pharmacokinetic (PK) Characterization of Subcutaneous Tulisokibart (MK-7240-010)

NCT06575595

COMPLETED Phase 1

A Clinical Study of Enlicitide Decanoate in People With Liver Function Problems (MK-0616-030)

NCT06575959

TERMINATED Phase 1

A Study of MK-6552 and the Effect of Food in Healthy Participants (MK-6552-006)

NCT06567002

COMPLETED Phase 1

A Study of Calderasib (MK-1084) With Midazolam and Digoxin in Healthy Participants (MK-1084-009)

NCT06575933

COMPLETED Phase 2

Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)

NCT06482112

COMPLETED Phase 1

A Study to Compare Oral Formulations of Tedizolid Phosphate in Healthy Adults (MK-1986-044)

NCT06609161

COMPLETED Phase 1

A Drug-Drug Interaction Study of Diltiazem and MK-5684 in Healthy Adult Male Participants (MK-5684-011)

NCT06554639

COMPLETED Phase 3

A Study to Evaluate the Efficacy and Safety of Enlicitide Decanoate (MK-0616, Oral PCSK9 Inhibitor) Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018) CORALreef AddOn

NCT06450366

COMPLETED Phase 1

A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)

NCT06625814

← Previous Page 5 of 12 Next →

Phase Distribution

PhaseTrial count
Phase 1 230
Phase 2 130
Phase 3 173
Phase 4 18

What the Pipeline for Merck Sharp & Dohme Shows

According to the ClinicalTrials.gov registry, Merck Sharp & Dohme is linked to 558 US clinical trials across every stage of research activity. Of those, 120 studies are currently recruiting, about 22% of the sponsor's indexed portfolio, and 320 are already marked complete, representing roughly 57% of the total.

The phase mix for Merck Sharp & Dohme reports 191 late-stage studies (Phase 3 and Phase 4 combined) and 360 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Merck Sharp & Dohme is Healthy with 25 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.