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NCT07121959 · ClinicalTrials.gov registry record · Phase 1
A Study of Belzutifan (MK-6482) and Metformin in Healthy Adult Participants (MK-6482-039)
A Phase 1 study, sponsored by Merck Sharp & Dohme.
- Completed
- Registry status
- Phase 1
- Development phase
- 14
- Enrollment target
NCT07121959: Completed Phase 1 study, sponsored by Merck Sharp & Dohme.
NCT07121959 is a Phase 1 study that has completed, run by Merck Sharp & Dohme. The registered enrollment target is 14 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07121959, a Phase 1 study, has completed, sponsored by Merck Sharp & Dohme.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 14 participants
- Enrollment target
Study Summary
The goal of this study is to learn how belzutifan (MK-6482) affects the levels of metformin in a healthy person's body over time. Researchers will study levels of metformin in the blood and urine in healthy volunteers after taking metformin alone (Period 1) and metformin with belzutifan (Period 2).
Primary Outcome
Blood samples will be collected to determine the AUC0-inf of metformin in plasma.
Interventions
- DRUG Belzutifan
- DRUG Metformin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2025-08-18 |
| Est. Completion | 2025-09-26 |
| Phase | Phase 1 |
What the finished NCT07121959 record still lists
NCT07121959 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 2 interventions - of which Belzutifan is the first listed.
NCT07121959 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07121959 about?
NCT07121959 is a clinical study titled "A Study of Belzutifan (MK-6482) and Metformin in Healthy Adult Participants (MK-6482-039)". The goal of this study is to learn how belzutifan (MK-6482) affects the levels of metformin in a healthy person's body over time. Researchers will study levels of metformin in the blood and urine in healthy volunteers after taking metformin alone (Period 1) and metformin with belzutifan (Period 2).
What is the current status of trial NCT07121959?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2025-08-18. Estimated completion is 2025-09-26.
What interventions are being tested in trial NCT07121959?
The interventions under investigation include: Belzutifan (DRUG), Metformin (DRUG).
Who is sponsoring clinical trial NCT07121959?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07121959's enrollment target sits among peer trials
14 1844th of 2000 higher than 154 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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