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NCT06942741 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Effect of Formulation and Food on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-011)
A Phase 1 study, sponsored by Merck Sharp & Dohme.
- Completed
- Registry status
- Phase 1
- Development phase
- 52
- Enrollment target
NCT06942741: Completed Phase 1 study, sponsored by Merck Sharp & Dohme.
NCT06942741 is a Phase 1 study that has completed, run by Merck Sharp & Dohme. The registered enrollment target is 52 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06942741, a Phase 1 study, has completed, sponsored by Merck Sharp & Dohme.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 52 participants
- Enrollment target
Study Summary
This study has 2 parts. Researchers want to learn what happens to calderasib in a healthy person's body over time in both parts. The goals of the study are: * In Part 1, to compare what happens to calderasib in a person's blood when it is taken as 2 different types of oral tablets * In Part 2, to learn what happens to calderasib in a person's blood when it is taken on an empty stomach or after a meal
Primary Outcome
Blood samples will be collected to determine the AUC0-last of calderasib.
Interventions
- DRUG Calderasib OCT
- DRUG Calderasib FCT
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52 participants |
| Start Date | 2025-05-13 |
| Est. Completion | 2025-08-04 |
| Phase | Phase 1 |
What the finished NCT06942741 record still lists
NCT06942741 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 52 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% lower).
The record links to 0 conditions, and to 2 interventions - of which Calderasib OCT is the first listed.
NCT06942741 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06942741 about?
NCT06942741 is a clinical study titled "A Study to Evaluate the Effect of Formulation and Food on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-011)". This study has 2 parts. Researchers want to learn what happens to calderasib in a healthy person's body over time in both parts. The goals of the study are: * In Part 1, to compare what happens to calderasib in a person's blood when it is taken as 2 different types of oral tablets * In Part 2, to l...
What is the current status of trial NCT06942741?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 52 participants. The study started on 2025-05-13. Estimated completion is 2025-08-04.
What interventions are being tested in trial NCT06942741?
The interventions under investigation include: Calderasib OCT (DRUG), Calderasib FCT (DRUG).
Who is sponsoring clinical trial NCT06942741?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06942741's enrollment target sits among peer trials
52 956th of 2000 higher than 1,032 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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