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ACTIVE NOT RECRUITING Phase 2

Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)

NCT03407144 · View on ClinicalTrials.gov ↗

Study Summary

This study will examine the safety and efficacy of pembrolizumab (MK-3475) in combination with chemotherapy in children and young adults with newly diagnosed classical Hodgkin Lymphoma (cHL) who are slow early responders (SERs) to frontline chemotherapy.

Conditions Studied

Interventions

  • BIOLOGICAL pembrolizumab
  • DRUG cyclophosphamide
  • DRUG doxorubicin
  • DRUG vinblastine
  • DRUG dacarbazine

Study Locations (20)

California

  • Kaiser - Orange County ( Site 0084) — Anaheim
  • Kaiser Permanente ( Site 0082) — Downey
  • Kaiser - Fontana ( Site 0083) — Fontana
  • MemorialCare Health System - Long Beach Medical Center-Cherese Mari Laulhere Children's Village ( Si — Long Beach
  • Kaiser Permanente Downey Medical Center ( Site 0024) — Los Angeles
  • Kaiser Permanente - Oakland ( Site 0047) — Oakland
  • Kaiser Permanente - Roseville ( Site 0080) — Roseville
  • Kaiser Permanente - Santa Clara ( Site 0079) — Santa Clara

Florida

  • University of Florida ( Site 0051) — Gainesville
  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital ( Site 0048) — Hollywood
  • Arnold Palmer Hospital ( Site 0065) — Orlando

Connecticut

  • Connecticut Children's Medical Center ( Site 0045) — Hartford
  • Yale Cancer Center ( Site 0061) — New Haven

Alabama

  • Children's Hospital of Alabama ( Site 0023) — Birmingham

Arizona

  • Phoenix Childrens Hospital ( Site 0034) — Phoenix

Arkansas

  • Arkansas Children's Hospital ( Site 0046) — Little Rock

Colorado

  • Children's Hospital - Colorado ( Site 0028) — Aurora

District of Columbia

  • Children's National Medical Center ( Site 0090) — Washington D.C.

Trial Details

FieldValue
Enrollment Target 340 participants
Start Date 2018-04-09
Est. Completion 2026-11-06
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03407144

The ClinicalTrials.gov registry entry for NCT03407144 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 340 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hodgkin Lymphoma appearing as the primary indexed condition, and to 5 interventions — of which pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03407144 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03407144 about?

NCT03407144 is a clinical study titled "Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)". This study will examine the safety and efficacy of pembrolizumab (MK-3475) in combination with chemotherapy in children and young adults with newly diagnosed classical Hodgkin Lymphoma (cHL) who are slow early responders (SERs) to frontline chemotherapy.

What is the current status of trial NCT03407144?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 340 participants. The study started on 2018-04-09. Estimated completion is 2026-11-06.

What conditions does trial NCT03407144 study?

This clinical trial studies the following conditions: Hodgkin Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03407144?

The interventions under investigation include: pembrolizumab (BIOLOGICAL), cyclophosphamide (DRUG), doxorubicin (DRUG), vinblastine (DRUG), dacarbazine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03407144?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03407144 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial