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ClinicalTrials.gov 6 recruiting now official registry

Carcinoma, Renal Cell clinical trials

Every US clinical trial registered for Carcinoma, Renal Cell — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

35 US clinical trials · 6 currently recruiting

The research picture

Carcinoma, Renal Cell has 35 registered US clinical trials, 6 of them open to new participants right now — about 17% of the total.

6
recruiting participants now
17%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
8
top sponsor: Merck Sharp & Dohme

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 949 participants

A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

NCT04895709

RECRUITING Phase 1 224 participants

A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

Pfizer

NCT07227415

RECRUITING 200 participants

Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)

Travera

NCT05461430

RECRUITING Phase 1 75 participants

Study of Orellanine in Metastatic Clear-Cell or Papillary Renal Cell Carcinoma

Oncorena AB

NCT05287945

RECRUITING Phase 2 42 participants

Autologous Dendritic Cell Vaccine in Kidney Cancer

Jodi Maranchie

NCT05127824

RECRUITING Phase 1 28 participants

Study to Evaluate the Safety and Efficacy of Bicalutamide in Combination with Sunitinib in Patients with TKIs-resistant RCC

State University of New York at Buffalo

NCT06222593

ACTIVE NOT RECRUITING Phase 3 1,800 participants

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

Merck Sharp & Dohme

NCT05239728

ACTIVE NOT RECRUITING Phase 3 1,653 participants

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Merck Sharp & Dohme

NCT04736706

ACTIVE NOT RECRUITING Phase 3 755 participants

A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

Merck Sharp & Dohme

NCT04195750

ACTIVE NOT RECRUITING Phase 3 747 participants

A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

Merck Sharp & Dohme

NCT04586231

ACTIVE NOT RECRUITING Phase 1 400 participants

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Merck Sharp & Dohme

NCT04626479

ACTIVE NOT RECRUITING Phase 1 370 participants

Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)

Merck Sharp & Dohme

NCT04626518

ACTIVE NOT RECRUITING Phase 2 154 participants

A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

Merck Sharp & Dohme

NCT04489771

ACTIVE NOT RECRUITING Phase 1 126 participants

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

Novartis Pharmaceuticals

NCT05544929

ACTIVE NOT RECRUITING 67 participants

Exploring Relevant Immune-based Biomarkers and Circulating Tumor Cells During Treatment With Immunotherapy in Genitourinary Malignancies (CTC Immune Based Biomarkers)

Duke University

NCT02978118

ACTIVE NOT RECRUITING Phase 3 60 participants

Savolitinib vs. Sunitinib in MET-driven PRCC.

AstraZeneca

NCT03091192

ACTIVE NOT RECRUITING Phase 1 52 participants

A Study of Belzutifan (MK-6482) in Participants With Advanced Clear Cell Renal Cell Carcinoma (MK-6482-018)

Merck Sharp & Dohme

NCT04846920

ACTIVE NOT RECRUITING Early Phase 1 17 participants

A Study of Combination Spartalizumab and Canakinumab in Patients With Localized Clear Cell Renal Cell Carcinoma

Columbia University

NCT04028245

COMPLETED Phase 3 750 participants

SU011248 Versus Interferon-Alfa As First-Line Systemic Therapy For Patients With Metastatic Renal Cell Carcinoma

Pfizer

NCT00083889

COMPLETED Phase 2 225 participants

GW786034 In Subjects With Locally Recurrent Or Metastatic Clear Cell Renal Cell Carcinoma

GlaxoSmithKline

NCT00244764

COMPLETED Phase 1 190 participants

A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab

Pfizer

NCT01307267

COMPLETED Phase 1 188 participants

Study To Assess Long Term Safety Of Pazopanib

Novartis Pharmaceuticals

NCT00387205

COMPLETED Phase 2 103 participants

Safety and Efficacy of ABT-510 in Subjects With Advanced Renal Cell Carcinoma

Abbott

NCT00073125

COMPLETED Phase 2 100 participants

Pazopanib (GW786034) In Subjects With Relapsed Or Refractory Multiple Myeloma

GlaxoSmithKline

NCT00256880

COMPLETED Phase 2 71 participants

Safety and Toxicity Study of Sorafenib in Patients With Kidney Cancer

The Methodist Hospital Research Institute

NCT00445042

COMPLETED Phase 2 54 participants

Evaluation of Bay 59-8862 in Patients With Advanced Renal Cell Carcinoma

Bayer

NCT00044564

COMPLETED Phase 2 43 participants

Study of Motexafin Gadolinium for the Treatment of Renal Cell (Kidney) Cancer

Pharmacyclics

NCT00134186

COMPLETED Phase 2 37 participants

A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H...

National Cancer Institute (NCI)

NCT00923481

COMPLETED Phase 1 34 participants

A Study to Assess the Safety, Pharmacokinetics and Effectiveness of AGS-16C3F Monotherapy in Subjects With Renal Cell Carcinoma (RCC) of Clear Cell or Papillary Histology

Agensys

NCT01672775

COMPLETED Phase 2 31 participants

PF-3512676 (CPG 7909) Injection For Patients Who Completed An Oncology Study Using PF-3512676 (CPG 7909)

Pfizer

NCT00043368

COMPLETED Phase 1 29 participants

Safety and Efficacy Study of GC1008 to Treat Renal Cell Carcinoma or Malignant Melanoma

Genzyme, a Sanofi Company

NCT00356460

COMPLETED Phase 2 25 participants

Safety and Biological Activity of TroVax® Vaccine Given With IL-2 in Renal Cell Carcinoma

Oxford BioMedica

NCT00325507

COMPLETED Phase 2 25 participants

A Study of TroVax Vaccine Given in Conjunction With IL-2 for Treatment of Stage IV Renal Cell Cancer

Oxford BioMedica

NCT00083941

COMPLETED Phase 2 7 participants

Alternative Schedule Sunitinib in Metastatic Renal Cell Carcinoma: Cardiopulmonary Exercise Testing

Duke University

NCT03109015

COMPLETED Phase 2 2 participants

Continuation Trial Evaluating the Tolerability and Activity of FK228 in Patients That Completed Prior Study With FK228

Celgene

NCT00106301

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 14
Phase 3 6

Top Sponsors

Pfizer 4 trials
Oxford BioMedica 2 trials
Duke University 2 trials
GlaxoSmithKline 2 trials
Agensys 1 trials
Abbott 1 trials
Pharmacyclics 1 trials
Oncorena AB 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Carcinoma, Renal Cell Trial Landscape

ClinicalTrials.gov lists 35 US studies indexed under Carcinoma, Renal Cell, and 6 of those are currently open to recruitment — roughly 17% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Carcinoma, Renal Cell shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 27 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Carcinoma, Renal Cell is led by Merck Sharp & Dohme with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 35 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Carcinoma, Renal Cell?

PlainTrial tracks 35 US clinical trials for Carcinoma, Renal Cell, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Carcinoma, Renal Cell?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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