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ClinicalTrials.gov official registry

Pneumococcal Infections clinical trials

All 11 indexed Pneumococcal Infections trials have closed enrollment.

11 US clinical trials ·

Pneumococcal Infections is the subject of 11 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 7 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Merck Sharp & Dohme, running 6 of these trials.

The research picture

Pneumococcal Infections has 11 registered US clinical trials; none are currently listed as recruiting, so most are completed or in follow-up.

0
recruiting participants now
0%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
6
top sponsor: Merck Sharp & Dohme
Phase 11Phase 21Phase 37

Active & Recent Trials

11 total, page 1 of 1

ACTIVE NOT RECRUITING Phase 3 1,268 participants

Study of the Safety and Immunogenicity of Catch-up Vaccination With a 21-valent Pneumococcal Conjugate Vaccine (PCV21) in Healthy Infants, Toddlers, Children, and Adolescents

Sanofi Pasteur, a Sanofi Company

NCT06838000

COMPLETED Phase 3 1,515 participants

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults at Increased Risk for Pneumococcal Disease (V114-017/PNEU-DAY)

Merck Sharp & Dohme

NCT03547167

COMPLETED Phase 3 1,205 participants

Safety and Immunogenicity of V114 in Healthy Adults (V114-019/PNEU-AGE)

Merck Sharp & Dohme

NCT03950622

COMPLETED Phase 3 1,200 participants

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 When Administered Concomitantly With Influenza Vaccine in Healthy Adults 50 Years of Age or Older (V114-021/PNEU-FLU)

Merck Sharp & Dohme

NCT03615482

COMPLETED Phase 2 1,051 participants

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Two Lots of V114 in Healthy Infants (V114-008)

Merck Sharp & Dohme

NCT02987972

COMPLETED Phase 3 938 participants

Study Evaluating The Safety, Tolerability And Immunogenicity Of A 13-Valent Pneumococcal Conjugate Vaccine (13vPnC)

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00546572

COMPLETED Phase 3 900 participants

A Study to Evaluate the Interchangeability of V114 and Prevnar 13™ in Healthy Infants (V114-027/PNEU-DIRECTION)

Merck Sharp & Dohme

NCT03620162

COMPLETED 326 participants

Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00000933

COMPLETED NA 300 participants

Pneumococcal Vaccine and Routine Pediatric Immunizations in HIV-Infected Children Receiving Anti-HIV Drugs

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00013871

COMPLETED Phase 3 277 participants

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Allogeneic Hematopoietic Stem Cell Transplant Recipients (V114-022/PNEU-STEM)

Merck Sharp & Dohme

NCT03565900

COMPLETED Phase 1 66 participants

A Phase 1, Randomized, Controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Conjugate Vaccine in Healthy Adults Aged 18 to 49 Years

Pfizer

NCT02955160

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 1
Phase 3 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pneumococcal Infections Trial Landscape

11 indexed Pneumococcal Infections studies · 0 recruiting (0%).

Phase mix: 7 late (III/IV) vs 2 early (I/II).

Top sponsor: Merck Sharp & Dohme (6 trials), 4 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pneumococcal Infections?

PlainTrial tracks 11 US clinical trials for Pneumococcal Infections, of which 0 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pneumococcal Infections?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.