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Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)
NCT06482112 · View on ClinicalTrials.gov ↗
Study Summary
This study will evaluate the effect of efinopegdutide administration once every 2 weeks (Q2W) versus once weekly (Q1W) on mean relative reduction from baseline in liver fat content (LFC) after 28 weeks, as well as the safety and tolerability of the different regimens of efinopegdutide.
Conditions Studied
Interventions
- DRUG Efinopegdutide
Study Locations (20)
California
- Om Research LLC ( Site 0207) — Camarillo
- Gastroenterology and Liver Institute ( Site 0263) — Escondido
- Velocity Clinical Research, Gardena ( Site 0235) — Gardena
- Velocity Clinical Research, Huntington Park ( Site 0210) — Huntington Park
- California Liver Research Institute ( Site 0216) — Pasadena
- Acclaim Clinical Research ( Site 0241) — San Diego
- Velocity Clinical Research, Santa Ana ( Site 0250) — Santa Ana
- Velocity Clinical Research, Panorama City ( Site 0228) — Van Nuys
Florida
- Excel Medical Clinical Trials ( Site 0268) — Boca Raton
- AGA Clinical Trials ( Site 0274) — Hialeah
- Neoclinical Research ( Site 0275) — Hialeah
- Homestead Associates in Research, Inc. ( Site 0243) — Homestead
- Floridian Clinical Research, LLC ( Site 0208) — Miami Lakes
Arizona
- The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0 — Chandler
- The Institute for Liver Health II dba Arizona Liver Health - Peoria ( Site 0224) — Peoria
- Arizona Liver Health ( Site 0211) — Tucson
- Del Sol Research Management, LLC ( Site 0209) — Tucson
Georgia
- Southeast Clinical Research Center ( Site 0223) — Dalton
Maryland
- Velocity Clinical Research Rockville ( Site 0245) — Rockville
Nevada
- The Machuca Foundation ( Site 0218) — Las Vegas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 124 participants |
| Start Date | 2024-07-29 |
| Est. Completion | 2025-06-27 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06482112
The ClinicalTrials.gov registry entry for NCT06482112 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 124 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Non-alcoholic Fatty Liver Disease appearing as the primary indexed condition, and to 1 intervention — of which Efinopegdutide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06482112 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06482112 about?
NCT06482112 is a clinical study titled "Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)". This study will evaluate the effect of efinopegdutide administration once every 2 weeks (Q2W) versus once weekly (Q1W) on mean relative reduction from baseline in liver fat content (LFC) after 28 weeks, as well as the safety and tolerability of the different regimens of efinopegdutide.
What is the current status of trial NCT06482112?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 124 participants. The study started on 2024-07-29. Estimated completion is 2025-06-27.
What conditions does trial NCT06482112 study?
This clinical trial studies the following conditions: Non-alcoholic Fatty Liver Disease, Liver Disease, Nonalcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatotic Liver Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06482112?
The interventions under investigation include: Efinopegdutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06482112?
This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06482112 being conducted?
This trial has 20 study locations across Arizona, California, Florida, Georgia, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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