Colgate Palmolive

Open enrollment with a later-stage pipeline tilt

According to ClinicalTrials.gov-derived indexes, Colgate Palmolive sits in the top decile of US sponsors by registered trial count (#372 of 15,742 sponsors by registered trial count).

51 total trials 3 currently recruiting 45 completed later-stage tilt top decile by trial count

Colgate Palmolive: 51 sponsored US clinical trials, 3 recruiting.

Colgate Palmolive sponsors 51 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 45 completed. 38 of these trials are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Gingivitis, with 3 trials.

Top-decile sponsor footprint

Colgate Palmolive ranks in the top decile of sponsors by registered trial count (#372 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

A 90/100

45 of 45 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (100.0%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

51 total, page 1 of 2

RECRUITING Phase 4

Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis

NCT07614490

RECRUITING Phase 3

Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion

NCT07442136

RECRUITING Phase 3

Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.

NCT07398846

ACTIVE NOT RECRUITING Phase 3

To Assess the Efficacy of Two Brushing Regimens: in the Reduction of Established Dental Plaque and Gingivitis.

NCT07605338

ACTIVE NOT RECRUITING

To Validate Changes in Knowledge, Attitudes and Practices (KAPs) Related to the Know Your OQ Initiative and to Understand the Readability, Comprehension and Ease of Use of the Know Your OQ Quiz

NCT06880458

NOT YET RECRUITING Phase 4

Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.

NCT06966492

COMPLETED Phase 3

Clinical Study to Evaluate the Tooth Whitening Efficacy of a New NextGen In-office Whitening System

NCT07225478

COMPLETED Phase 3

To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.

NCT07149376

COMPLETED Phase 3

Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal Hypersensitivity

NCT07257042

COMPLETED Phase 4

Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis

NCT07029438

COMPLETED Phase 3

Clinical Study to Evaluate the Tooth Whitening Efficacy

NCT06957249

COMPLETED NA

Clinical Study to Assess the Efficacy of Professional Tooth Whitening Maintenance System

NCT06613347

COMPLETED

Assessing the Colgate Assist Handle Toothbrush in Individuals With Impairment of Hand Movement.

NCT06632704

COMPLETED Phase 2

Clinical Investigation to Assess the Efficacy of Manual Toothbrushes in the Reduction of Plaque and Gingivitis.

NCT06565897

COMPLETED Phase 3

Arginine Plaque Metabolism Pilot Clinical Study

NCT06954779

COMPLETED Phase 3

Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.

NCT06244303

COMPLETED Phase 1

Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101

NCT06182267

COMPLETED

Children in the Operating Room: Kids That go Thru Operating Room Will be Given a Connected Health Toothbrush, Kids Anticavity Toothpaste and Behavioral Health Intervention to Reduce Claim Costs

NCT07539064

COMPLETED

Documenting Toothbrushing Experiences of Caregivers Who Care for Children With Autism Spectrum Disorders

NCT05552144

COMPLETED Phase 2

A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children

NCT04750902

COMPLETED Phase 3

Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products

NCT04864925

COMPLETED Phase 2

Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria Saliva and Bioaerosol Contamination Phase 2

NCT04717063

COMPLETED Phase 2

Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria in Saliva and Bioaerosol Contamination

NCT04626778

COMPLETED Phase 3

Dentinal Hypersensitivity Reduction

NCT06244290

COMPLETED Phase 3

Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

NCT06300866

COMPLETED NA

Clinical Investigation Examining Plaque and Gingivitis Connected Toothbrush Compared to Non-Connected Toothbrush

NCT04221334

COMPLETED Phase 4

Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste

NCT04033575

COMPLETED Phase 4

Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)

NCT02366689

COMPLETED Phase 4

The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US

NCT02360995

COMPLETED Phase 4

Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria

NCT02194621

COMPLETED Phase 4

Compare Anti-inflammatory Dentifrices

NCT00762528

COMPLETED Phase 3

The Efficacy of a Toothpaste to Reduce Sensitivity

NCT00763269

COMPLETED Phase 3

Clinical Efficacy of 10% Arginine Bicarbonate Prophylaxis Paste

NCT01072188

COMPLETED Phase 3

Clinical Study to Evaluate Dental Plaque

NCT00758290

COMPLETED NA

Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction

NCT01040169

COMPLETED Phase 3

Investigate Oral Bacteria in Adult Population

NCT00762177

COMPLETED Phase 3

Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse

NCT01024738

COMPLETED Phase 3

Compare the Clinical Efficacy of Prototype Toothpastes.

NCT00761930

COMPLETED Phase 3

Collection of Gingival Crevicular Fluid From Periodontitis Patients

NCT00763048

COMPLETED Phase 3

Train New Examiners Via Modified Gingival Margin Plaque

NCT00758563

COMPLETED Phase 3

Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes

NCT00762515

COMPLETED Phase 3

Investigation of Dental Plaque and Gingival Index

NCT00759031

COMPLETED Phase 3

Evaluate Clinical Research From Commerical Oral Care Products

NCT00759187

COMPLETED Phase 3

Compare the Clinical Efficacy of Prototype Toothpastes

NCT00926029

COMPLETED Phase 3

Training and Calibration of Dental Examiners

NCT00765167

COMPLETED Phase 3

Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.

NCT00966953

COMPLETED Phase 3

Clinical Research Study Efficacy of a Prototype Oral Rinse

NCT01021007

COMPLETED Phase 3

Clinical Study to Compare Dental Plaque Control

NCT00758394

COMPLETED Phase 2

Evaluating Commercial Anti-Plaque Products and Oral Rinse

NCT01014143

COMPLETED Phase 3

Clinical Study to Examine Brushing on Dental Implants

NCT00762619

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Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 5
Phase 3 29
Phase 4 9

Where Colgate Palmolive enrollment is open (later-stage tilt)

3 recruiting of 51 indexed (6% open); 45 completed (88%).

Phase mix: 38 late (III/IV) vs 6 early (I/II) (later-stage heavy).

Top condition: Gingivitis (3 trials), 7 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Colgate Palmolive: open-pipeline peers nationwide

Peers matched on 51 registered trials and 6% open enrollment, not the therapeutic-area sidebar.

Colgate Palmolive sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 102030405060 0%5%10%15% Total trials Recruiting share Colgate PalmoliveMedtronicNeuroOhio UniversityReproductive Medicine Associates of New JerseyTexas Woman's UniversityBioDelivery Sciences InternationalDurham VA Medical CenterEssentia HealthMadrigal Pharmaceuticals
Colgate Palmolive sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Colgate Palmolive sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 51 trials (± recruiting share)

Sponsors near 6% open enrollment (± trial volume)

What to do with this Colgate Palmolive page

51 registered trials is a research-attention snapshot, not an endorsement of Colgate Palmolive or any single study.

  • 3 of Colgate Palmolive's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Gingivitis is the condition Colgate Palmolive studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Gingivitis trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Colgate Palmolive pipeline card: 51 registered trials from official public datasets.Report a data error.