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Dental Caries clinical trials
Every US clinical trial registered for Dental Caries — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
31 US clinical trials · 5 currently recruiting
The research picture
Dental Caries has 31 registered US clinical trials, 5 of them open to new participants right now — about 16% of the total.
- 5
- recruiting participants now
- 16%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Solventum US
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Advancing Water Security: A Community Participatory School-Based Hydration Intervention
Virginia Commonwealth University
NCT06714929
Oral Health Intervention in Adult Primary Care
Case Western Reserve University
NCT06555029
LT Comparative Effectiveness of 2 Caries Treatments
Case Western Reserve University
NCT07213661
Comparing Stainless Steel Crowns with Prefabricated Resin Crowns in Primary Molar Teeth
Children's Hospital Medical Center, Cincinnati
NCT06713330
Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries
University of California, San Francis
NCT06727110
In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization
Incisive Technologies Pty
NCT07100626
DPBRN Reasons for Placing the First Restoration on Permanent Tooth Surfaces
Dental Practice-Based Research Network
NCT00847470
DPBRN Longitudinal Study of Questionable Occlusal Caries Lesions
Dental Practice-Based Research Network
NCT01309971
A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children
Colgate Palmolive
NCT04750902
Xylitol for Caries Prevention in Inner-City Children
Case Western Reserve University
NCT01901250
The Children's Amalgam Trial
Carelon Research
NCT00065988
CAMBRA - PBRN Caries Management By Risk Assessment In A Practice-Based Research Network
University of California, San Francis
NCT01176396
Phase 2 Study to Evaluate the Microbiology and Safety of C16G2 Administered to Adult and Adolescent Dental Subjects
Armata Pharmaceuticals
NCT02594254
High-strength Glass-ionomer Dental Restorations
Mathilde Peters, DMD, PhD
NCT01523613
Enamel Remineralization Potential of Dentifrices in Situ
GlaxoSmithKline
NCT01128946
Oral Hygiene Intervention Pilot Study
Leonardo Marchini
NCT02668809
Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth
Solventum US
NCT01369108
Efficacy of Three Toothpastes Using an in Situ Caries Model
GlaxoSmithKline
NCT02751320
A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model
GlaxoSmithKline
NCT01607411
Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations
Solventum US
NCT02889835
Study of the Composition of Dental Plaque
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00001726
Clinical Evaluation of Three Dental Adhesive Systems in Class V Restorations
Solventum US
NCT00643461
MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
University of California, San Francis
NCT02424097
Clinical Evaluation of a Bulk Fill Resin Composite
Ivoclar Vivadent
NCT04686422
Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors
University of North Carolina, Chapel Hill
NCT02885064
Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste
Church & Dwight Company
NCT07419685
Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste
Church & Dwight Company
NCT07419763
Periodontal and Periapical Inflammation and Pregnancy
Roger Johnson
NCT00490165
Impact of Compliance With Fluoride Use on Caries Incidence After Cancer Therapy
A.T. Still University of Health Sciences
NCT03267914
Isolite and Dental Treatment Under Conscious Sedation
The University of Texas Health Science Center at San Antonio
NCT01683851
Safety Evaluation of Advantage Anti-Caries Varnish
Advantage Dental Services
NCT02645617
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 2 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Dental Caries Trial Landscape
ClinicalTrials.gov lists 31 US studies indexed under Dental Caries, and 5 of those are currently open to recruitment — roughly 16% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Dental Caries shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Dental Caries is led by Solventum US with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 31 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Dental Caries?
PlainTrial tracks 31 US clinical trials for Dental Caries, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Dental Caries?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.