Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Dental Caries: full-pipeline trial registry
5 of 31 indexed Dental Caries trials are currently recruiting.
Corpus placement: #495 of 28,707 conditions by registered trial count.
31 US clinical trials · 5 currently recruiting · #495 of 28,707 conditions by registered trial count
Dental Caries: 31 US clinical trials tracked, 5 recruiting.
Dental Caries is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Solventum US, running 3 of these trials.
Enrollment posture brief
Registry condition dental-caries
OPEN 5 | RECR 16% | LATE 4 | EARLY 3 | RANK #495 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Stage II Breast Cancer (16% recruiting · 31 trials)
Dental Caries lists 5 open slots (16% of 31 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Dental Caries on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Dental Caries is recruiting below its size-band peers.
5 of 31 indexed trials (16.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Dental Caries trials is spread across many organizations.
Solventum US accounts for 3 of 31 trials (9.7%). 21 distinct sponsors appear on at least one study for this condition label.
-
Most Dental Caries trials plan to enrol fewer than 100 people.
Median target enrolment is 55 among the 31 trials that report a genuine target (sentinel values excluded). 21 of those (67.7%) plan for fewer than 100 participants.
-
Dental Caries research is mostly interventional.
24 interventional and 7 observational studies make up this index (77.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
31 total, page 1 of 1
Advancing Water Security: A Community Participatory School-Based Hydration Intervention
Virginia Commonwealth University
NCT06714929
Oral Health Intervention in Adult Primary Care
Case Western Reserve University
NCT06555029
LT Comparative Effectiveness of 2 Caries Treatments
Case Western Reserve University
NCT07213661
Comparing Stainless Steel Crowns with Prefabricated Resin Crowns in Primary Molar Teeth
Children's Hospital Medical Center, Cincinnati
NCT06713330
Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries
University of California, San Francisco
NCT06727110
In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization
Incisive Technologies Pty
NCT07100626
DPBRN Reasons for Placing the First Restoration on Permanent Tooth Surfaces
Dental Practice-Based Research Network
NCT00847470
DPBRN Longitudinal Study of Questionable Occlusal Caries Lesions
Dental Practice-Based Research Network
NCT01309971
A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children
Colgate Palmolive
NCT04750902
Xylitol for Caries Prevention in Inner-City Children
Case Western Reserve University
NCT01901250
The Children's Amalgam Trial
Carelon Research
NCT00065988
CAMBRA - PBRN Caries Management By Risk Assessment In A Practice-Based Research Network
University of California, San Francisco
NCT01176396
Phase 2 Study to Evaluate the Microbiology and Safety of C16G2 Administered to Adult and Adolescent Dental Subjects
Armata Pharmaceuticals
NCT02594254
High-strength Glass-ionomer Dental Restorations
Mathilde Peters, DMD, PhD
NCT01523613
Enamel Remineralization Potential of Dentifrices in Situ
GlaxoSmithKline
NCT01128946
Oral Hygiene Intervention Pilot Study
Leonardo Marchini
NCT02668809
Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth
Solventum US
NCT01369108
Efficacy of Three Toothpastes Using an in Situ Caries Model
GlaxoSmithKline
NCT02751320
A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model
GlaxoSmithKline
NCT01607411
Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations
Solventum US
NCT02889835
Study of the Composition of Dental Plaque
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00001726
Clinical Evaluation of Three Dental Adhesive Systems in Class V Restorations
Solventum US
NCT00643461
MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
University of California, San Francisco
NCT02424097
Clinical Evaluation of a Bulk Fill Resin Composite
Ivoclar Vivadent
NCT04686422
Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors
University of North Carolina, Chapel Hill
NCT02885064
Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste
Church & Dwight Company
NCT07419685
Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste
Church & Dwight Company
NCT07419763
Periodontal and Periapical Inflammation and Pregnancy
Roger Johnson
NCT00490165
Impact of Compliance With Fluoride Use on Caries Incidence After Cancer Therapy
A.T. Still University of Health Sciences
NCT03267914
Isolite and Dental Treatment Under Conscious Sedation
The University of Texas Health Science Center at San Antonio
NCT01683851
Safety Evaluation of Advantage Anti-Caries Varnish
Advantage Dental Services
NCT02645617
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 2 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Dental Caries records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Dental Caries trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Dental Caries page
31 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 5 Dental Caries trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Solventum US sponsors the most Dental Caries trials on record, review their full trial history before evaluating a specific study. See Solventum US's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Dental Caries condition card totals 31 registered trials; most-linked intervention Negative Control Toothpaste; top US site state Indiana. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.