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NCT06966492 · ClinicalTrials.gov registry record · Phase 4
Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.
A Phase 4 study, sponsored by Colgate Palmolive.
- Not yet
- Registry status
- Phase 4
- Development phase
- 20
- Enrollment target
NCT06966492: Clinical Trial Phase 4 study, sponsored by Colgate Palmolive.
NCT06966492 is a Phase 4 study that has not yet begun recruiting, run by Colgate Palmolive. The registered enrollment target is 20 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06966492, a Phase 4 study, has not yet begun recruiting, sponsored by Colgate Palmolive.
- NOT YET RECRUITING
- Registry status
- Phase 4
- Development phase
- 20 participants
- Enrollment target
Study Summary
This is a clinical research study designed to measure changes in inflammation and the oral microbiome during a phase of good oral hygiene and the absence of oral hygiene. The goal of the study is to investigate the interplay between local oral inflammation, microbiota and systemic immune responses.
Primary Outcome
Gingival Bleeding Index (Ainamo \& Bay, 1976) The six surfaces of teeth will be scored and recorded for absence or presence of bleeding after gentle probing.
Interventions
- DRUG Stannous Fluoride Toothpaste (SnF)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-06 |
| Est. Completion | 2027-06 |
| Phase | Phase 4 |
What is known before NCT06966492 opens enrollment
NCT06966492 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Stannous Fluoride Toothpaste (SnF) is the first listed.
NCT06966492 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06966492 about?
NCT06966492 is a clinical study titled "Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.". This is a clinical research study designed to measure changes in inflammation and the oral microbiome during a phase of good oral hygiene and the absence of oral hygiene. The goal of the study is to investigate the interplay between local oral inflammation, microbiota and systemic immune responses.
What is the current status of trial NCT06966492?
This trial is currently not yet recruiting. It is a Phase 4 study. The enrollment target is 20 participants. The study started on 2026-06. Estimated completion is 2027-06.
What interventions are being tested in trial NCT06966492?
The interventions under investigation include: Stannous Fluoride Toothpaste (SnF) (DRUG).
Who is sponsoring clinical trial NCT06966492?
This trial is sponsored by Colgate Palmolive, which has 51 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06966492's enrollment target sits among peer trials
20 1753rd of 2000 higher than 167 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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