Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07442136 · ClinicalTrials.gov registry record · Phase 3
Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion
A Phase 3 study of Enamel Erosion, sponsored by Colgate Palmolive.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT07442136: Recruiting Phase 3 study of Enamel Erosion, sponsored by Colgate Palmolive.
NCT07442136 is a Phase 3 study of Enamel Erosion that is actively recruiting participants, run by Colgate Palmolive. The registered enrollment target is 80 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07442136, a Phase 3 study of Enamel Erosion, is actively recruiting participants, sponsored by Colgate Palmolive.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn if a new toothpaste can prevent enamel erosion in healthy adults. Researchers will compare the test toothpaste to a control toothpaste to see if there is a difference in erosion levels. Participants will brush twice a day for two minutes with their assigned toothpaste.
Primary Outcome
Depth of surface loss in an enamel block worn on a dental retainer by the participant, as determined by an optical profilometer.
Conditions Studied
Interventions
- DRUG New Toothpaste Containing SnF
- DRUG Fluoride Toothpaste
Study Locations (1)
Texas
- School of Dentistry, University of Texas Health San Antonio - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2026-03-03 |
| Est. Completion | 2026-04 |
| Phase | Phase 3 |
What NCT07442136 shows while recruiting
NCT07442136 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Enamel Erosion appearing as the primary indexed condition, and to 2 interventions - of which New Toothpaste Containing SnF is the first listed.
NCT07442136 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT07442136 about?
NCT07442136 is a clinical study titled "Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion". The goal of this clinical trial is to learn if a new toothpaste can prevent enamel erosion in healthy adults. Researchers will compare the test toothpaste to a control toothpaste to see if there is a difference in erosion levels. Participants will brush twice a day for two minutes with their assigne...
What is the current status of trial NCT07442136?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 80 participants. The study started on 2026-03-03. Estimated completion is 2026-04.
What conditions does trial NCT07442136 study?
This clinical trial studies the following conditions: Enamel Erosion.
What interventions are being tested in trial NCT07442136?
The interventions under investigation include: New Toothpaste Containing SnF (DRUG), Fluoride Toothpaste (DRUG).
Who is sponsoring clinical trial NCT07442136?
This trial is sponsored by Colgate Palmolive, which has 51 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07442136 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Enamel Erosion
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07442136's enrollment target sits among peer trials
80 1756th of 2000 higher than 233 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01243931 · 80 participants · NA
Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
- NCT01659203 · 80 participants · Phase 1
Proton or Photon RT for Retroperitoneal Sarcomas
- NCT01803451 · 80 participants · Early Phase 1
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
- NCT01964859 · 80 participants · Phase 2
Feasibility Study for Fibroblast Autologous Skin Grafts
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI