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NCT07149376 · ClinicalTrials.gov registry record · Phase 3
To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.
A Phase 3 study, sponsored by Colgate Palmolive.
- Completed
- Registry status
- Phase 3
- Development phase
- 84
- Enrollment target
NCT07149376: Completed Phase 3 study, sponsored by Colgate Palmolive.
NCT07149376 is a Phase 3 study that has completed, run by Colgate Palmolive. The registered enrollment target is 84 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07149376, a Phase 3 study, has completed, sponsored by Colgate Palmolive.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 84 participants
- Enrollment target
Study Summary
The objective of this clinical investigation is to assess the efficacy of a toothpaste containing 8% arginine (Colgate-Palmolive Company, New York, NY, USA) as compared to a commercially available non-desensitizing toothpaste (Colgate Cavity Protection Toothpaste, Colgate-Palmolive Company, New York, NY, USA) in the reduction of dentinal hypersensitivity over an eight (8) week period.
Primary Outcome
Hypersensitivity defined by a response score in the range of 10-50 grams of force.
Interventions
- DEVICE TOMs of Maine Sensitive SLS Free Xtra Fresh
- DRUG Colgate Cavity protection toothpaste
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2025-08-18 |
| Est. Completion | 2025-10-14 |
| Phase | Phase 3 |
What the finished NCT07149376 record still lists
NCT07149376 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 84 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 2 interventions - of which TOMs of Maine Sensitive SLS Free Xtra Fresh is the first listed.
NCT07149376 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07149376 about?
NCT07149376 is a clinical study titled "To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.". The objective of this clinical investigation is to assess the efficacy of a toothpaste containing 8% arginine (Colgate-Palmolive Company, New York, NY, USA) as compared to a commercially available non-desensitizing toothpaste (Colgate Cavity Protection Toothpaste, Colgate-Palmolive Company, New York...
What is the current status of trial NCT07149376?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 84 participants. The study started on 2025-08-18. Estimated completion is 2025-10-14.
What interventions are being tested in trial NCT07149376?
The interventions under investigation include: TOMs of Maine Sensitive SLS Free Xtra Fresh (DEVICE), Colgate Cavity protection toothpaste (DRUG).
Who is sponsoring clinical trial NCT07149376?
This trial is sponsored by Colgate Palmolive, which has 51 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07149376's enrollment target sits among peer trials
84 1749th of 2000 higher than 250 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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