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ClinicalTrials.gov 5 recruiting now official registry

Gingivitis clinical trials

5 of 26 indexed Gingivitis trials are currently recruiting.

26 US clinical trials · 5 currently recruiting

Gingivitis is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Procter and Gamble, running 5 of these trials.

The research picture

Gingivitis has 26 registered US clinical trials, 5 of them open to new participants right now, about 19% of the total.

5
recruiting participants now
19%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
5
top sponsor: Procter and Gamble
Phase 12Phase 21Phase 32Phase 43

Active & Recent Trials

26 total, page 1 of 1

RECRUITING NA 300 participants

A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation

HALEON

NCT07255040

RECRUITING NA 275 participants

Imaging-based Assessment of Oral Biofilm and Gingival Health

University of California, Irvine

NCT05470023

RECRUITING NA 198 participants

Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral Surgery

Children's Hospital Los Angeles

NCT06122805

RECRUITING NA 150 participants

Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control

Missouri Department of Health and Senior Services

NCT06890676

RECRUITING NA 80 participants

Variation in Gingival Inflammatory Responses

University of Washington

NCT05968742

ACTIVE NOT RECRUITING Phase 1 135 participants

Evaluating Gingivitis and Systemic Biomarkers

Procter and Gamble

NCT06962956

ACTIVE NOT RECRUITING Phase 4 120 participants

Assessing Gingivitis and Plaque From a Marketed Toothpaste

Procter and Gamble

NCT07158112

ACTIVE NOT RECRUITING NA 50 participants

Motivational Interviewing to Improve Oral Hygiene in Adolescent Orthodontic Patients

University of Alabama at Birmingham

NCT07164989

COMPLETED 2,929 participants

A Meta-analysis Comparing Toothbrushes on Plaque Removal and Gingival Health

Procter and Gamble

NCT05594004

COMPLETED NA 253 participants

Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease

GlaxoSmithKline

NCT02750943

COMPLETED NA 199 participants

A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation

HALEON

NCT06660069

COMPLETED Phase 1 157 participants

Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque

Johnson & Johnson Consumer Inc. (J&JCI)

NCT04921371

COMPLETED NA 152 participants

Incentives for Daily Tooth Brushing to Reduce Gingivitis

University of Pennsylvania

NCT02160418

COMPLETED NA 136 participants

A Clinical Study to Evaluate the Efficacy of a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation

HALEON

NCT06933368

COMPLETED Phase 2 97 participants

Dose-Response Study of Iocide Oral Rinse

Biomedical Development Corporation

NCT01103102

COMPLETED NA 90 participants

ToothWave Calculus Reduction and Accumulation Prevention Study

Home Skinovations

NCT04596761

COMPLETED Phase 4 88 participants

Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste

Colgate Palmolive

NCT04033575

COMPLETED NA 86 participants

ToothWave Plaque and Gingivitis Study

Home Skinovations

NCT03885323

COMPLETED Phase 3 82 participants

Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.

Colgate Palmolive

NCT06244303

COMPLETED NA 81 participants

Oral Hygiene Intervention Pilot Study

Leonardo Marchini

NCT02668809

COMPLETED Phase 3 80 participants

Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

Colgate Palmolive

NCT06300866

COMPLETED Phase 4 69 participants

A Study is to Evaluate a Regimen on Gingivitis Using Traditional and Novel Assessment Methods

Procter and Gamble

NCT07211061

COMPLETED NA 60 participants

A Pilot Study to Evaluate a Method for Plaque When Comparing Stannous Fluoride Toothpaste to a Regular Dentifrice

Procter and Gamble

NCT02543060

COMPLETED 34 participants

Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors

University of North Carolina, Chapel Hill

NCT02885064

COMPLETED NA 10 participants

Evaluation of Toothbrush Bristles in Plaque Reduction

Sunstar Americas

NCT04681885

COMPLETED NA 6 participants

Atlas of Experimental Gingivitis in Humans

University of North Carolina, Chapel Hill

NCT04105569

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 1
Phase 3 2
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gingivitis Trial Landscape

26 indexed Gingivitis studies · 5 recruiting (19%).

Phase mix: 5 late (III/IV) vs 3 early (I/II).

Top sponsor: Procter and Gamble (5 trials), 9 others listed. 26 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gingivitis?

PlainTrial tracks 26 US clinical trials for Gingivitis, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gingivitis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.