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ClinicalTrials.gov 37 recruiting now official registry

Urothelial Carcinoma clinical trials

37 of 86 indexed Urothelial Carcinoma trials are currently recruiting.

86 US clinical trials · 37 currently recruiting

Urothelial Carcinoma is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 59 in Phase 1-2 (earlier-stage). The most active sponsor is Fox Chase Cancer Center, running 6 of these trials.

The research picture

Urothelial Carcinoma has 86 registered US clinical trials, 37 of them open to new participants right now, about 43% of the total.

37
recruiting participants now
43%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
6
top sponsor: Fox Chase Cancer Center
Phase 137Phase 222Phase 36

Active & Recent Trials

86 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 2 60 participants

Enfortumab Vedotin Schedule De-escalation in Metastatic Urothelial Carcinoma

Fox Chase Cancer Center

NCT05923190

ACTIVE NOT RECRUITING Phase 1 54 participants

A Phase II Study of Atezolizumab in Combination With Cisplatin + Gemcitabine Before Surgery to Remove the Bladder Cancer

Memorial Sloan Kettering Cancer Center

NCT02989584

ACTIVE NOT RECRUITING Phase 1 48 participants

A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)

Merck Sharp & Dohme

NCT05562830

ACTIVE NOT RECRUITING Phase 2 46 participants

Pembrolizumab in Muscle-invasive Bladder Cancer

Matthew Galsky

NCT05406713

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING Phase 2 32 participants

A Study of Two Dosing Schedules of Atezolizumab in Combination With Gemcitabine and Cisplatin as First-Line Treatment for Metastatic Bladder Cancer

Memorial Sloan Kettering Cancer Center

NCT03093922

ACTIVE NOT RECRUITING Phase 2 21 participants

Atezolizumab + Guadecitabine in Patients With Checkpoint Inhibitor Refractory or Resistant Urothelial Carcinoma

Fox Chase Cancer Center

NCT03179943

ACTIVE NOT RECRUITING Phase 1 19 participants

Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma

University of Oklahoma

NCT04004442

ACTIVE NOT RECRUITING Early Phase 1 16 participants

18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy

Brigham and Women's Hospital

NCT04018053

ACTIVE NOT RECRUITING Phase 2 15 participants

Neoadjuvant Nivolumab With and Without Urelumab in Cisplatin-Ineligible or Chemotherapy-refusing Patients With Muscle-Invasive Urothelial Carcinoma of the Bladder

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02845323

ACTIVE NOT RECRUITING Phase 2 12 participants

A Phase II Multicenter Study of Chemotherapy Versus Chemotherapy Plus Durvalumab (MEDI 4736) in Patients With Lymph Node Positive Urothelial Carcinoma of the Bladder

M.D. Anderson Cancer Center

NCT05137262

ACTIVE NOT RECRUITING Phase 2 10 participants

A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma

M.D. Anderson Cancer Center

NCT05335941

ACTIVE NOT RECRUITING Phase 1 9 participants

Intravesical Adoptive Cell Therapy w/ TIL for BCG Exposed High Grade NMIBC

H. Lee Moffitt Cancer Center and Research Institute

NCT05768347

COMPLETED 803 participants

The Cxbladder Monitoring Study

Pacific Edge Limited

NCT02700659

COMPLETED NA 554 participants

STRATA: Safe Testing of Risk for AsymptomaTic MicrohematuriA

Pacific Edge Limited

NCT03988309

COMPLETED NA 219 participants

UC-GENOME: Urothelial Cancer-GENOmic Analysis to iMprove Patient Outcomes and rEsearch

Matthew Milowsky, MD

NCT02643043

COMPLETED 181 participants

Prevalence of PD-L1 Expression in Patients With Advanced Urothelial Carcinoma

AstraZeneca

NCT03788746

COMPLETED Phase 1 150 participants

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors

Xencor

NCT03517488

COMPLETED Phase 1 95 participants

Derazantinib and Atezolizumab in Patients With Urothelial Cancer

Basilea Pharmaceutica

NCT04045613

COMPLETED Phase 1 78 participants

A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

Ikena Oncology

NCT04200963

COMPLETED Phase 2 69 participants

Cabozantinib for Advanced Urothelial Cancer

National Cancer Institute (NCI)

NCT01688999

COMPLETED Phase 1 44 participants

LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors

PureTech

NCT04666688

COMPLETED Phase 1 43 participants

Study of the CD40 Agonistic Monoclonal Antibody APX005M

Apexigen America

NCT02482168

COMPLETED Phase 1 38 participants

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Tempest Therapeutics

NCT03829436

COMPLETED Phase 1 37 participants

Phase 1b/2 Study of Rogaratinib (BAY1163877) in Combination With Atezolizumab in Urothelial Carcinoma

Bayer

NCT03473756

COMPLETED Phase 2 36 participants

First-Line Gemcitabine, Cisplatin + Ipilimumab for Metastatic Urothelial Carcinoma

Hoosier Cancer Research Network

NCT01524991

COMPLETED Phase 2 30 participants

A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer

OncoNano Medicine

NCT03735680

COMPLETED Phase 1 29 participants

A Study of a Personalized Neoantigen Cancer Vaccine

Gritstone bio

NCT03639714

COMPLETED NA 27 participants

SAbR Induced Innate Immunity in Urothelial Carcinoma, Melanoma, and Cervical Carcinoma

University of Texas Southwestern Medical Center

NCT02986867

COMPLETED Early Phase 1 20 participants

Copper Cu-64 TP3805 PET/CT in Imaging Patients With Urothelial Cancer Undergoing Surgery or Biopsy

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT03039413

COMPLETED Phase 1 19 participants

A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors

Cantargia AB

NCT04452214

COMPLETED Phase 1 12 participants

IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors

H. Lee Moffitt Cancer Center and Research Institute

NCT03758781

COMPLETED Phase 1 11 participants

GEN-001 (Live Biotherapeutic Product) and Avelumab Combination Study for Patients With Solid Tumors Who Have Progressed on Anti-PD-(L)1 Therapy

Genome & Company

NCT04601402

COMPLETED Phase 2 8 participants

Genomic Based Assignment of Therapy in Advanced Urothelial Carcinoma

National Cancer Institute (NCI)

NCT02788201

COMPLETED Phase 1 8 participants

Trial of Intravesical Measles Virotherapy in Patients With Bladder Cancer Who Are Undergoing Radical Cystectomy

Vyriad

NCT03171493

COMPLETED Phase 3 8 participants

Feasibility of Home Instillation of UGN-102 for Treatment of Low-Grade (LG) Non-Muscle Invasive Bladder Cancer (NMIBC)

UroGen Pharma

NCT05136898

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Phase Distribution

PhaseTrial count
Phase 1 37
Phase 2 22
Phase 3 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Urothelial Carcinoma Trial Landscape

86 indexed Urothelial Carcinoma studies · 37 recruiting (43%).

Phase mix: 6 late (III/IV) vs 59 early (I/II).

Top sponsor: Fox Chase Cancer Center (6 trials), 9 others listed. 36 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Urothelial Carcinoma?

PlainTrial tracks 86 US clinical trials for Urothelial Carcinoma, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Urothelial Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.