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NCT01688999 · ClinicalTrials.gov registry record · Phase 2
Cabozantinib for Advanced Urothelial Cancer
A Phase 2 study of Urothelial Carcinoma and Urinary Bladder Neoplasms, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 2
- Development phase
- 69
- Enrollment target
- 1
- Study location
NCT01688999 is a Phase 2 study of Urothelial Carcinoma and Urinary Bladder Neoplasms that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 69 participants, below the 238-participant average among 85 other Urothelial Carcinoma trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01688999, a Phase 2 study of Urothelial Carcinoma and Urinary Bladder Neoplasms, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 69 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: \- Cabozantinib is a drug that slows the growth of blood vessels that feed tumors. It is approved for medullary thyroid cancer. However, studies have shown that prostate and ovarian tumors respond to it. Researchers want see if cabozantinib can be a safe and effective treatment for urothelial cancer. Objectives: \- To test the safety and effectiveness of cabozantinib for advanced urothelial cancer. Eligibility: \- Individuals at least 18 years of age who have advanced urothelial cancer that has not responded to standard treatments. Design: * Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. Tumor tissue samples will also be collected. Imaging studies will also be performed. * Participants will take cabozantinib by mouth once per day on each day of a 28-day cycle. * Treatment will be monitored with frequent blood tests and imaging studies. * Participants will continue to take the study drug for as long as their cancer does not worsen and side effects are not too severe.
Conditions Studied
Interventions
- DRUG Cabozantinib
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 69 participants |
| Start Date | 2012-09-11 |
| Est. Completion | 2020-09-14 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01688999
The ClinicalTrials.gov registry entry for NCT01688999 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 69 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 238-participant average among 85 other Urothelial Carcinoma trials with a reported enrollment target (71% lower). The listed sponsor is National Cancer Institute (NCI), which has 3,257 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Urothelial Carcinoma appearing as the primary indexed condition, and to 1 intervention - of which Cabozantinib is the first listed.
NCT01688999 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT01688999 about?
NCT01688999 is a clinical study titled "Cabozantinib for Advanced Urothelial Cancer". Background: \- Cabozantinib is a drug that slows the growth of blood vessels that feed tumors. It is approved for medullary thyroid cancer. However, studies have shown that prostate and ovarian tumors respond to it. Researchers want see if cabozantinib can be a safe and effective treatment for urot...
What is the current status of trial NCT01688999?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 69 participants. The study started on 2012-09-11. Estimated completion is 2020-09-14.
What conditions does trial NCT01688999 study?
This clinical trial studies the following conditions: Urothelial Carcinoma, Urinary Bladder Neoplasms, Kidney Neoplasms, Urethral Neoplasms.
What interventions are being tested in trial NCT01688999?
The interventions under investigation include: Cabozantinib (DRUG).
Who is sponsoring clinical trial NCT01688999?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01688999 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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