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COMPLETED Phase 1

A Study of a Personalized Neoantigen Cancer Vaccine

NCT03639714 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the safety, dose, immunogenicity and early clinical activity of GRT-C901 and GRT-R902, a personalized neoantigen cancer vaccine, in combination with nivolumab and ipilimumab, in patients with metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, gastroesophageal adenocarcinoma, and metastatic urothelial cancer.

Interventions

  • BIOLOGICAL nivolumab
  • BIOLOGICAL ipilimumab
  • BIOLOGICAL GRT-C901
  • BIOLOGICAL GRT-R902

Study Locations (11)

New York

  • Memorial Sloan Kettering Cancer Center — New York
  • Columbia University Medical Center — New York

Arizona

  • Mayo Clinic Arizona — Phoenix

Florida

  • Mayo Clinic — Jacksonville

Illinois

  • The University of Chicago — Chicago

Minnesota

  • Mayo Clinic — Rochester

Ohio

  • The Ohio State University Comprehensive Cancer Center — Columbus

Tennessee

  • Tennessee Oncology — Nashville

Texas

  • MD Anderson Cancer Center — Houston

Trial Details

FieldValue
Enrollment Target 29 participants
Start Date 2019-02-13
Est. Completion 2022-11-10
Phase Phase 1

Sponsor

Gritstone bio

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03639714

The ClinicalTrials.gov registry entry for NCT03639714 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gritstone bio, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 4 interventions — of which nivolumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03639714 reports 11 study locations spanning 10 distinct geographic areas — top geographies include New York, Arizona, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03639714 about?

NCT03639714 is a clinical study titled "A Study of a Personalized Neoantigen Cancer Vaccine". The purpose of this study is to evaluate the safety, dose, immunogenicity and early clinical activity of GRT-C901 and GRT-R902, a personalized neoantigen cancer vaccine, in combination with nivolumab and ipilimumab, in patients with metastatic non-small cell lung cancer, microsatellite stable colore...

What is the current status of trial NCT03639714?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 2019-02-13. Estimated completion is 2022-11-10.

What conditions does trial NCT03639714 study?

This clinical trial studies the following conditions: Colorectal Cancer, Non Small Cell Lung Cancer, Urothelial Carcinoma, Gastroesophageal Adenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03639714?

The interventions under investigation include: nivolumab (BIOLOGICAL), ipilimumab (BIOLOGICAL), GRT-C901 (BIOLOGICAL), GRT-R902 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03639714?

This trial is sponsored by Gritstone bio, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03639714 being conducted?

This trial has 11 study locations across Arizona, Florida, Illinois, Minnesota, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial