Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Traumatic Brain Injury: early-phase trial registry
75 of 172 indexed Traumatic Brain Injury trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #63 of 28,707 conditions by registered trial count.
172 US clinical trials · 75 currently recruiting · #63 of 28,707 conditions by registered trial count
Traumatic Brain Injury: 172 US clinical trials tracked, 75 recruiting.
Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
Enrollment posture brief
Registry condition traumatic-brain-injury
OPEN 75 | RECR 44% | LATE 5 | EARLY 23 | RANK #63 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Binge-Eating Disorder (44% recruiting · 39 trials)
Traumatic Brain Injury lists 75 open slots (44% of 172 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Traumatic Brain Injury on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Traumatic Brain Injury is recruiting above its size-band peers.
75 of 172 indexed trials (43.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Traumatic Brain Injury trials is spread across many organizations.
VA Office of Research and Development accounts for 11 of 172 trials (6.4%). 95 distinct sponsors appear on at least one study for this condition label.
-
Typical Traumatic Brain Injury enrolment sits around 80 participants.
Median target enrolment is 80 among the 172 trials that report a genuine target (sentinel values excluded). 99 of those (57.6%) plan for fewer than 100 participants.
-
Traumatic Brain Injury research is mostly interventional.
122 interventional and 50 observational studies make up this index (70.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
172 total, page 2 of 4
GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI
Albert Einstein Healthcare Network
NCT06028334
Brain Balance Study
VA Office of Research and Development
NCT05714150
TMS-fNIRS Personalized Dosing
Florida State University
NCT05916417
Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents
Uniformed Services University of the Health Sciences
NCT07267819
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
Jorge Gonzalez-Martinez
NCT07056348
Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation
Shirley Ryan AbilityLab
NCT06589362
Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control
Jorge Gonzalez-Martinez
NCT07056361
Using Virtual Reality to Improve Job Reentry in Adults With TBI
Kessler Foundation
NCT04820634
Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury
Kessler Foundation
NCT05716048
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
Hope Biosciences
NCT05951777
Community-based Implementation of Online EmReg
Icahn School of Medicine at Mount Sinai
NCT05933629
Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)
University of Miami
NCT06293300
NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury
Kessler Foundation
NCT06584591
Remote Stimulation and Training to Advance Recovery From TBI in Seniors
Minneapolis Veterans Affairs Medical Center
NCT07332299
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
University of Alabama at Birmingham
NCT06217575
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
The University of Texas Health Science Center at San Antonio
NCT07351305
Visual Plasticity Following Brain Lesions
Georgetown University
NCT07105358
Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury
University of Texas Southwestern Medical Center
NCT04242602
Robotic Balance Training to Improve Postural Control and Balance Post-Traumatic Brain Injury
Kessler Foundation
NCT06184295
Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury
Beth Israel Deaconess Medical Center
NCT06848140
Development Of a Virtual Stress Inoculation Training (SIT) Platform and Mobile Health App
The University of Texas Health Science Center, Houston
NCT06494319
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
University of Maryland, Baltimore
NCT06103201
Reliability and Validity of the PReFS
Baylor University
NCT07280923
Cortical Spreading Depolarization After Severe Traumatic Brain Injury
Hennepin County Medical Center, Minneapolis
NCT03321370
Ketamine in Severe Traumatic Brain Injury
University of Texas Southwestern Medical Center
NCT06062628
Implementation of Neuro Lung Protective Ventilation
Colin Grissom
NCT03243539
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Vanderbilt University Medical Center
NCT03098459
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)
University of Pennsylvania
NCT05823766
TRACK-TBI Longitudinal Biomarker Study
University of Pennsylvania
NCT05201833
Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans
Portland VA Medical Center
NCT03968874
Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)
The University of Texas Health Science Center, Houston
NCT00178659
Re-entry Continuum for Brain Injury
Rehabilitation Hospital of Indiana
NCT04386681
Expanding Delivery of an Evidence-based Weight-loss Intervention to Enhance Access and Reach Underserved Groups After TBI
Baylor Research Institute
NCT05699772
Intervention to Change Affect Recognition and Empathy
Indiana University
NCT05636020
Cognitive Rehabilitation of Blast Traumatic Brain Injury (TBI)
VA Office of Research and Development
NCT01138020
Telerehabilitation Early After CNS Injury
TRCare
NCT06069999
Group Lifestyle Balance™ for Individuals With Traumatic Brain Injury (GLB-TBI)
Baylor Research Institute
NCT03594734
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
University of Massachusetts, Worcester
NCT05671874
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Phase 2 Option 1
University of California, San Francisco
NCT04602806
Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).
SHINKEI Therapeutics
NCT06253923
Transcranial Direct Current Stimulation (TDCS) as an Intervention for Patients With Traumatic Brain Injury
Minneapolis Veterans Affairs Medical Center
NCT02849223
Narrative Discourse Treatment Development
VA Office of Research and Development
NCT05008419
Combined tDCS and Cognitive Training to Reduce Impulsivity in Patients With Traumatic Brain Injury
Minneapolis Veterans Affairs Medical Center
NCT03844607
3D Transcranial Ultrasound Brain Imaging (3D-TRUBI) Instrument for Point-of-Care Diagnosis of Intracranial Hemorrhages
The Geneva Foundation
NCT06780436
Functional Near-Infrared Spectroscopy (fNIRS) Assessing Neural Activity During Virtual Reality Walking Intervention
Craig Hospital
NCT06276894
Brain Stimulation for Concussion
The Mind Research Network
NCT05889117
LED Treatment to Improve Cognition and Promote Recovery in TBI
VA Office of Research and Development
NCT02404402
Evaluation of Biomarkers of Traumatic Brain Injury
Banyan Biomarkers
NCT01426919
Traumatic Brain Injury Among Homeless Veterans
VA Eastern Colorado Health Care System
NCT01120054
Evaluation and Diagnosis of Potential Research Subjects With Traumatic Brain Injury
National Institute of Nursing Research (NINR)
NCT01287156
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 12 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Traumatic Brain Injury records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Traumatic Brain Injury trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Traumatic Brain Injury page
172 registered trials, 75 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 75 Traumatic Brain Injury trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Traumatic Brain Injury trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Traumatic Brain Injury condition card totals 172 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.