Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Traumatic Brain Injury clinical trials
75 of 172 indexed Traumatic Brain Injury trials are currently recruiting.
172 US clinical trials · 75 currently recruiting
Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
The research picture
Traumatic Brain Injury has 172 registered US clinical trials, 75 of them open to new participants right now, about 44% of the total.
- 75
- recruiting participants now
- 44%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 11
- top sponsor: VA Office of Research and Development
Active & Recent Trials
172 total, page 2 of 4
GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI
Albert Einstein Healthcare Network
NCT06028334
Brain Balance Study
VA Office of Research and Development
NCT05714150
TMS-fNIRS Personalized Dosing
Florida State University
NCT05916417
Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents
Uniformed Services University of the Health Sciences
NCT07267819
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
Jorge Gonzalez-Martinez
NCT07056348
Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation
Shirley Ryan AbilityLab
NCT06589362
Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control
Jorge Gonzalez-Martinez
NCT07056361
Using Virtual Reality to Improve Job Reentry in Adults With TBI
Kessler Foundation
NCT04820634
Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury
Kessler Foundation
NCT05716048
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
Hope Biosciences
NCT05951777
Community-based Implementation of Online EmReg
Icahn School of Medicine at Mount Sinai
NCT05933629
Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)
University of Miami
NCT06293300
NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury
Kessler Foundation
NCT06584591
Remote Stimulation and Training to Advance Recovery From TBI in Seniors
Minneapolis Veterans Affairs Medical Center
NCT07332299
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
University of Alabama at Birmingham
NCT06217575
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
The University of Texas Health Science Center at San Antonio
NCT07351305
Visual Plasticity Following Brain Lesions
Georgetown University
NCT07105358
Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury
University of Texas Southwestern Medical Center
NCT04242602
Robotic Balance Training to Improve Postural Control and Balance Post-Traumatic Brain Injury
Kessler Foundation
NCT06184295
Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury
Beth Israel Deaconess Medical Center
NCT06848140
Development Of a Virtual Stress Inoculation Training (SIT) Platform and Mobile Health App
The University of Texas Health Science Center, Houston
NCT06494319
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
University of Maryland, Baltimore
NCT06103201
Reliability and Validity of the PReFS
Baylor University
NCT07280923
Cortical Spreading Depolarization After Severe Traumatic Brain Injury
Hennepin County Medical Center, Minneapolis
NCT03321370
Ketamine in Severe Traumatic Brain Injury
University of Texas Southwestern Medical Center
NCT06062628
Implementation of Neuro Lung Protective Ventilation
Colin Grissom
NCT03243539
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Vanderbilt University Medical Center
NCT03098459
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)
University of Pennsylvania
NCT05823766
TRACK-TBI Longitudinal Biomarker Study
University of Pennsylvania
NCT05201833
Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans
Portland VA Medical Center
NCT03968874
Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)
The University of Texas Health Science Center, Houston
NCT00178659
Re-entry Continuum for Brain Injury
Rehabilitation Hospital of Indiana
NCT04386681
Expanding Delivery of an Evidence-based Weight-loss Intervention to Enhance Access and Reach Underserved Groups After TBI
Baylor Research Institute
NCT05699772
Intervention to Change Affect Recognition and Empathy
Indiana University
NCT05636020
Cognitive Rehabilitation of Blast Traumatic Brain Injury (TBI)
VA Office of Research and Development
NCT01138020
Telerehabilitation Early After CNS Injury
TRCare
NCT06069999
Group Lifestyle Balance™ for Individuals With Traumatic Brain Injury (GLB-TBI)
Baylor Research Institute
NCT03594734
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
University of Massachusetts, Worcester
NCT05671874
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Phase 2 Option 1
University of California, San Francisco
NCT04602806
Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).
SHINKEI Therapeutics
NCT06253923
Transcranial Direct Current Stimulation (TDCS) as an Intervention for Patients With Traumatic Brain Injury
Minneapolis Veterans Affairs Medical Center
NCT02849223
Narrative Discourse Treatment Development
VA Office of Research and Development
NCT05008419
Combined tDCS and Cognitive Training to Reduce Impulsivity in Patients With Traumatic Brain Injury
Minneapolis Veterans Affairs Medical Center
NCT03844607
3D Transcranial Ultrasound Brain Imaging (3D-TRUBI) Instrument for Point-of-Care Diagnosis of Intracranial Hemorrhages
The Geneva Foundation
NCT06780436
Functional Near-Infrared Spectroscopy (fNIRS) Assessing Neural Activity During Virtual Reality Walking Intervention
Craig Hospital
NCT06276894
Brain Stimulation for Concussion
The Mind Research Network
NCT05889117
LED Treatment to Improve Cognition and Promote Recovery in TBI
VA Office of Research and Development
NCT02404402
Evaluation of Biomarkers of Traumatic Brain Injury
Banyan Biomarkers
NCT01426919
Traumatic Brain Injury Among Homeless Veterans
VA Eastern Colorado Health Care System
NCT01120054
Evaluation and Diagnosis of Potential Research Subjects With Traumatic Brain Injury
National Institute of Nursing Research (NINR)
NCT01287156
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 12 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Traumatic Brain Injury Trial Landscape
172 indexed Traumatic Brain Injury studies · 75 recruiting (44%).
Phase mix: 5 late (III/IV) vs 23 early (I/II).
Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Traumatic Brain Injury?
PlainTrial tracks 172 US clinical trials for Traumatic Brain Injury, of which 75 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Traumatic Brain Injury?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.