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ClinicalTrials.gov 75 recruiting now official registry

Traumatic Brain Injury clinical trials

75 of 172 indexed Traumatic Brain Injury trials are currently recruiting.

172 US clinical trials · 75 currently recruiting

Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.

The research picture

Traumatic Brain Injury has 172 registered US clinical trials, 75 of them open to new participants right now, about 44% of the total.

75
recruiting participants now
44%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
11
top sponsor: VA Office of Research and Development
Phase 111Phase 212Phase 33Phase 42

Active & Recent Trials

172 total, page 2 of 4

RECRUITING NA 70 participants

GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI

Albert Einstein Healthcare Network

NCT06028334

RECRUITING NA 70 participants

Brain Balance Study

VA Office of Research and Development

NCT05714150

RECRUITING NA 60 participants

TMS-fNIRS Personalized Dosing

Florida State University

NCT05916417

RECRUITING 60 participants

Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents

Uniformed Services University of the Health Sciences

NCT07267819

RECRUITING NA 60 participants

Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

Jorge Gonzalez-Martinez

NCT07056348

RECRUITING NA 60 participants

Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation

Shirley Ryan AbilityLab

NCT06589362

RECRUITING NA 60 participants

Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control

Jorge Gonzalez-Martinez

NCT07056361

RECRUITING NA 60 participants

Using Virtual Reality to Improve Job Reentry in Adults With TBI

Kessler Foundation

NCT04820634

RECRUITING Phase 1 60 participants

Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury

Kessler Foundation

NCT05716048

RECRUITING Phase 2 51 participants

Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury

Hope Biosciences

NCT05951777

RECRUITING NA 50 participants

Community-based Implementation of Online EmReg

Icahn School of Medicine at Mount Sinai

NCT05933629

RECRUITING Phase 2 50 participants

Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)

University of Miami

NCT06293300

RECRUITING NA 45 participants

NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury

Kessler Foundation

NCT06584591

RECRUITING NA 40 participants

Remote Stimulation and Training to Advance Recovery From TBI in Seniors

Minneapolis Veterans Affairs Medical Center

NCT07332299

RECRUITING NA 36 participants

Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans

University of Alabama at Birmingham

NCT06217575

RECRUITING NA 30 participants

Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

The University of Texas Health Science Center at San Antonio

NCT07351305

RECRUITING NA 30 participants

Visual Plasticity Following Brain Lesions

Georgetown University

NCT07105358

RECRUITING NA 30 participants

Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury

University of Texas Southwestern Medical Center

NCT04242602

RECRUITING NA 30 participants

Robotic Balance Training to Improve Postural Control and Balance Post-Traumatic Brain Injury

Kessler Foundation

NCT06184295

RECRUITING NA 24 participants

Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

Beth Israel Deaconess Medical Center

NCT06848140

RECRUITING NA 20 participants

Development Of a Virtual Stress Inoculation Training (SIT) Platform and Mobile Health App

The University of Texas Health Science Center, Houston

NCT06494319

RECRUITING Phase 1 15 participants

Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury

University of Maryland, Baltimore

NCT06103201

RECRUITING 15 participants

Reliability and Validity of the PReFS

Baylor University

NCT07280923

RECRUITING 10 participants

Cortical Spreading Depolarization After Severe Traumatic Brain Injury

Hennepin County Medical Center, Minneapolis

NCT03321370

RECRUITING Early Phase 1 10 participants

Ketamine in Severe Traumatic Brain Injury

University of Texas Southwestern Medical Center

NCT06062628

ACTIVE NOT RECRUITING NA 728 participants

Implementation of Neuro Lung Protective Ventilation

Colin Grissom

NCT03243539

ACTIVE NOT RECRUITING 432 participants

Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study

Vanderbilt University Medical Center

NCT03098459

ACTIVE NOT RECRUITING 300 participants

Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)

University of Pennsylvania

NCT05823766

ACTIVE NOT RECRUITING 300 participants

TRACK-TBI Longitudinal Biomarker Study

University of Pennsylvania

NCT05201833

ACTIVE NOT RECRUITING NA 300 participants

Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans

Portland VA Medical Center

NCT03968874

ACTIVE NOT RECRUITING 260 participants

Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)

The University of Texas Health Science Center, Houston

NCT00178659

ACTIVE NOT RECRUITING NA 102 participants

Re-entry Continuum for Brain Injury

Rehabilitation Hospital of Indiana

NCT04386681

ACTIVE NOT RECRUITING NA 85 participants

Expanding Delivery of an Evidence-based Weight-loss Intervention to Enhance Access and Reach Underserved Groups After TBI

Baylor Research Institute

NCT05699772

ACTIVE NOT RECRUITING NA 85 participants

Intervention to Change Affect Recognition and Empathy

Indiana University

NCT05636020

ACTIVE NOT RECRUITING NA 77 participants

Cognitive Rehabilitation of Blast Traumatic Brain Injury (TBI)

VA Office of Research and Development

NCT01138020

ACTIVE NOT RECRUITING NA 60 participants

Telerehabilitation Early After CNS Injury

TRCare

NCT06069999

ACTIVE NOT RECRUITING NA 57 participants

Group Lifestyle Balance™ for Individuals With Traumatic Brain Injury (GLB-TBI)

Baylor Research Institute

NCT03594734

ACTIVE NOT RECRUITING NA 50 participants

Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI

University of Massachusetts, Worcester

NCT05671874

ACTIVE NOT RECRUITING 50 participants

Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Phase 2 Option 1

University of California, San Francisco

NCT04602806

ACTIVE NOT RECRUITING Phase 2 45 participants

Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).

SHINKEI Therapeutics

NCT06253923

ACTIVE NOT RECRUITING Phase 2 41 participants

Transcranial Direct Current Stimulation (TDCS) as an Intervention for Patients With Traumatic Brain Injury

Minneapolis Veterans Affairs Medical Center

NCT02849223

ACTIVE NOT RECRUITING NA 34 participants

Narrative Discourse Treatment Development

VA Office of Research and Development

NCT05008419

ACTIVE NOT RECRUITING NA 33 participants

Combined tDCS and Cognitive Training to Reduce Impulsivity in Patients With Traumatic Brain Injury

Minneapolis Veterans Affairs Medical Center

NCT03844607

ACTIVE NOT RECRUITING 20 participants

3D Transcranial Ultrasound Brain Imaging (3D-TRUBI) Instrument for Point-of-Care Diagnosis of Intracranial Hemorrhages

The Geneva Foundation

NCT06780436

ACTIVE NOT RECRUITING NA 15 participants

Functional Near-Infrared Spectroscopy (fNIRS) Assessing Neural Activity During Virtual Reality Walking Intervention

Craig Hospital

NCT06276894

ACTIVE NOT RECRUITING NA 15 participants

Brain Stimulation for Concussion

The Mind Research Network

NCT05889117

ACTIVE NOT RECRUITING NA 8 participants

LED Treatment to Improve Cognition and Promote Recovery in TBI

VA Office of Research and Development

NCT02404402

COMPLETED 2,011 participants

Evaluation of Biomarkers of Traumatic Brain Injury

Banyan Biomarkers

NCT01426919

COMPLETED 2,000 participants

Traumatic Brain Injury Among Homeless Veterans

VA Eastern Colorado Health Care System

NCT01120054

COMPLETED 1,328 participants

Evaluation and Diagnosis of Potential Research Subjects With Traumatic Brain Injury

National Institute of Nursing Research (NINR)

NCT01287156

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Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 12
Phase 3 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Traumatic Brain Injury Trial Landscape

172 indexed Traumatic Brain Injury studies · 75 recruiting (44%).

Phase mix: 5 late (III/IV) vs 23 early (I/II).

Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Traumatic Brain Injury?

PlainTrial tracks 172 US clinical trials for Traumatic Brain Injury, of which 75 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Traumatic Brain Injury?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.