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ClinicalTrials.gov 75 recruiting now official registry

Traumatic Brain Injury clinical trials

75 of 172 indexed Traumatic Brain Injury trials are currently recruiting.

172 US clinical trials · 75 currently recruiting

Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.

The research picture

Traumatic Brain Injury has 172 registered US clinical trials, 75 of them open to new participants right now, about 44% of the total.

75
recruiting participants now
44%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
11
top sponsor: VA Office of Research and Development
Phase 111Phase 212Phase 33Phase 42

Active & Recent Trials

172 total, page 1 of 4

RECRUITING 15,000 participants

Evaluation of the SCALED (SCaling AcceptabLE cDs)

University of Minnesota

NCT05628207

RECRUITING 2,000 participants

Phase I Human Analytics (HALO) Study

HALO Diagnostics

NCT05423860

RECRUITING 2,000 participants

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Hoffmann-La Roche

NCT07455136

RECRUITING 2,000 participants

Retinal Imaging in Neurodegenerative Disease

Duke University

NCT03233646

RECRUITING 1,200 participants

Real Time Vital Sign Assessment to Predict Neurological Decline After Traumatic Brain Injury

University of Maryland, Baltimore

NCT05084352

RECRUITING Phase 4 600 participants

Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide

Wake Forest University Health Sciences

NCT06866691

RECRUITING NA 600 participants

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Massachusetts General Hospital

NCT04296604

RECRUITING 581 participants

CoMind Early Feasibility Study

CoMind Technologies Limited

NCT06368648

RECRUITING NA 500 participants

Neurologic Stem Cell Treatment Study

MD Stem Cells

NCT02795052

RECRUITING NA 450 participants

Evaluation of the Abbott i-STAT TBI Biomarker Test

Icahn School of Medicine at Mount Sinai

NCT06766435

RECRUITING Phase 3 420 participants

Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury

University of South Florida

NCT06581003

RECRUITING NA 360 participants

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Johns Hopkins University

NCT05663034

RECRUITING 300 participants

The EBC Recovery Study

University of Miami

NCT04712591

RECRUITING 300 participants

University of Pittsburgh Brain Health Initiative

David Okonkwo, MD, PhD

NCT04708613

RECRUITING 300 participants

Cognitive and Vascular Functioning Following TBI

Walter Reed National Military Medical Center

NCT06034509

RECRUITING NA 300 participants

Pilot Study of BCAA on Sleep

Portland VA Medical Center

NCT03990909

RECRUITING 240 participants

Traumatic Brain Injury and Stroke Long Term Outcome

Centre for Neuro Skills

NCT03399929

RECRUITING NA 221 participants

Non-invasive Nerve Stimulation for PTSD and Sleep

University of Florida

NCT03170440

RECRUITING NA 200 participants

Carbon Dioxide Administration and Brain Waste Clearance

Andrew Mayer

NCT07357090

RECRUITING NA 200 participants

Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery

Children's Hospital Medical Center, Cincinnati

NCT05622461

RECRUITING Phase 2 200 participants

Hyperbaric Oxygen Brain Injury Treatment Trial

Gaylan Rockswold

NCT02407028

RECRUITING 169 participants

Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics

Wake Forest University Health Sciences

NCT06697808

RECRUITING NA 160 participants

The REACH Intervention for Caregivers of Veterans and Service Members With TBI

University of Virginia

NCT06111794

RECRUITING NA 160 participants

Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

University of Pittsburgh

NCT02592291

RECRUITING Phase 4 160 participants

Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures

University of Michigan

NCT07225101

RECRUITING Phase 2 160 participants

Sildenafil for Microvasculopathy in Chronic TBI

University of Pennsylvania

NCT05782244

RECRUITING 150 participants

A Study to Evaluate the SENSE Device's Ability to Detect TBI

Sense Diagnostics

NCT06828107

RECRUITING NA 150 participants

Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury.

NYU Langone Health

NCT04349852

RECRUITING 150 participants

The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

University of Michigan

NCT04855396

RECRUITING NA 138 participants

MENTOR Wellness Program

NYU Langone Health

NCT06148324

RECRUITING NA 136 participants

Treating Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation

The University of Texas at Dallas

NCT04869059

RECRUITING NA 135 participants

Personalized Cognitive Integrated Motor Training Using Virtual Reality to Improve Gait and Balance

Kessler Foundation

NCT06473987

RECRUITING NA 132 participants

Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation

Florida State University

NCT06544408

RECRUITING Early Phase 1 126 participants

Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System

Virginia Commonwealth University

NCT06188364

RECRUITING 120 participants

Predict Severe Traumatic Brain Injury

University of Chicago

NCT06966713

RECRUITING NA 120 participants

TBI Rehabilitation and Activation in Veterans

Northern California Institute of Research and Education

NCT06562127

RECRUITING NA 120 participants

Objectively Diagnose and Monitor Treatment of Light Sensitivity

Randy Kardon

NCT03694626

RECRUITING Phase 2 120 participants

Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI

NYU Langone Health

NCT04550377

RECRUITING Phase 2 111 participants

High Intensity Step Training After Traumatic Brain Injury

Craig Hospital

NCT05702138

RECRUITING 110 participants

Longitudinal Assessment of Traumatic Microvascular Injury-2

University of Pennsylvania

NCT05725993

RECRUITING NA 108 participants

Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury

University of New Mexi

NCT05236010

RECRUITING NA 100 participants

Eye Recovery Automation for Post Injury Dysfunction (iRAPID)

New Jersey Institute of Technology

NCT06105892

RECRUITING NA 100 participants

Non-invasive BCI-controlled Assistive Devices

University of Texas at Austin

NCT05183152

RECRUITING NA 96 participants

Improving Sleep in Veterans With the Polytrauma Clinical Triad

VA Office of Research and Development

NCT06477796

RECRUITING NA 90 participants

Amygdala Memory Enhancement

Washington University School of Medicine

NCT05065450

RECRUITING Phase 1 90 participants

Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury

University of Arizona

NCT06282965

RECRUITING NA 80 participants

University of Colorado - Restoring Efficient Sleep After TBI

VA Eastern Colorado Health Care System

NCT05683145

RECRUITING 75 participants

Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series

Reset Medical and Wellness Center

NCT07473505

RECRUITING Phase 2 72 participants

Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)

University of Cincinnati

NCT05337618

RECRUITING NA 70 participants

tPBM in Older Adults With Traumatic Brain Injury

NYU Langone Health

NCT06956404

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Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 12
Phase 3 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Traumatic Brain Injury Trial Landscape

172 indexed Traumatic Brain Injury studies · 75 recruiting (44%).

Phase mix: 5 late (III/IV) vs 23 early (I/II).

Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Traumatic Brain Injury?

PlainTrial tracks 172 US clinical trials for Traumatic Brain Injury, of which 75 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Traumatic Brain Injury?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.