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Traumatic Brain Injury: early-phase trial registry
75 of 172 indexed Traumatic Brain Injury trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #63 of 28,707 conditions by registered trial count.
172 US clinical trials · 75 currently recruiting · #63 of 28,707 conditions by registered trial count
Traumatic Brain Injury: 172 US clinical trials tracked, 75 recruiting.
Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
Enrollment posture brief
Registry condition traumatic-brain-injury
OPEN 75 | RECR 44% | LATE 5 | EARLY 23 | RANK #63 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Binge-Eating Disorder (44% recruiting · 39 trials)
Traumatic Brain Injury lists 75 open slots (44% of 172 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Traumatic Brain Injury on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Traumatic Brain Injury is recruiting above its size-band peers.
75 of 172 indexed trials (43.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Traumatic Brain Injury trials is spread across many organizations.
VA Office of Research and Development accounts for 11 of 172 trials (6.4%). 95 distinct sponsors appear on at least one study for this condition label.
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Typical Traumatic Brain Injury enrolment sits around 80 participants.
Median target enrolment is 80 among the 172 trials that report a genuine target (sentinel values excluded). 99 of those (57.6%) plan for fewer than 100 participants.
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Traumatic Brain Injury research is mostly interventional.
122 interventional and 50 observational studies make up this index (70.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
172 total, page 3 of 4
Prehospital Tranexamic Acid Use for Traumatic Brain Injury
University of Washington
NCT01990768
Evaluation of Mild TBI in Collegiate Athletes
Banyan Biomarkers
NCT02189525
Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing
University of Washington
NCT00194441
Neural Markers and Rehabilitation of Executive Functioning in Veterans With Traumatic Brain Injury and Posttraumatic Stress Disorder
University of North Carolina, Chapel Hill
NCT01410721
An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans
VA Eastern Colorado Health Care System
NCT01502436
Evaluation of an Intervention Model for Family Crisis and Support
Virginia Commonwealth University
NCT00205530
Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder
Wave Neuroscience
NCT02990793
Effects of Aerobic Exercise on Cognition, Mood and Fatigue Following TBI
Icahn School of Medicine at Mount Sinai
NCT00619463
Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study
Children's Hospital Medical Center, Cincinnati
NCT01042899
Spreading Depolarizations in Traumatic Brain Injury
University of Cincinnati
NCT03379220
Online Emotion Regulation Group Intervention
Icahn School of Medicine at Mount Sinai
NCT03479606
Internet-Based Treatment for Children With Traumatic Brain Injuries & Their Families: Counselor Assisted Problem Solving
Children's Hospital Medical Center, Cincinnati
NCT00409448
Evaluation OF Biomarkers OF Traumatic Brain Injury Extension Study
Banyan Biomarkers
NCT02439736
SMS Messaging to Reduce Depression and Anxiety Following TBI
Albert Einstein Healthcare Network
NCT02061553
Internet-based Interacting Together Everyday, Recovery After Childhood TBI (I-InTERACT)--RRTC
Children's Hospital Medical Center, Cincinnati
NCT01214694
Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study
University of Alabama at Birmingham
NCT03797378
Personalized, Augmented Cognitive Training (PACT) for Service Members and Veterans with a History of TBI
Veterans Medical Research Foundation
NCT04560946
Acute Cognitive and Neurobehavioral Intervention: Efficacy Evaluation
Virginia Commonwealth University
NCT00205569
Estimating Brain Biomechanics Using MRI
National Institutes of Health Clinical Center (CC)
NCT01633268
Measure of Cerebrovascular Dysfunction After TBI With fNIRS
Uniformed Services University of the Health Sciences
NCT01789164
Approaches to Auditory Rehabilitation for Mild Traumatic Brain Injury
US Department of Veterans Affairs
NCT00930774
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
VA Office of Research and Development
NCT01670526
Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury
Baylor College of Medicine
NCT00704379
Improving Health Outcomes With Resource Facilitation
Rehabilitation Hospital of Indiana
NCT04462549
Improving Family Quality of Life Through Training to Reduce Care-Resistant Behaviors by People With AD and TBI
University of Alabama at Birmingham
NCT03734289
Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury
Posit Science Corporation
NCT01640158
Telerehabilitation for OIF/OEF Returnees With Combat-Related Traumatic Brain Injury
VA Office of Research and Development
NCT00676182
Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment
Kessler Foundation
NCT02020564
The Effect of Exercise on Mood After Traumatic Brain Injury
University of Washington
NCT00571545
Improving Executive Functions After Traumatic Brain Injury (TBI): A Clinical Trial of the "Executive Plus" Program
Icahn School of Medicine at Mount Sinai
NCT00233129
A Health & Wellness Intervention for Individuals With Traumatic Brain Injury (TBI)
VA Eastern Colorado Health Care System
NCT01334398
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
VA Office of Research and Development
NCT02391402
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
The University of Texas Medical Branch, Galveston
NCT03554265
Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression
Wake Forest University Health Sciences
NCT00621751
Geri-TBI: A Prospective Multi-center Evaluation of Geriatric Patients With Traumatic Brain Injury
Methodist Health System
NCT05171010
MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury
University of California, San Francisco
NCT01298557
Functional Connectivity as a Biomarker of rTMS
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03050801
Efficacy Study of Strattera for Treating Attention Disorders in Traumatic Brain Injury (TBI)
Craig Hospital
NCT00702364
Validity and Feasibility of the CRSR-FAST
Massachusetts General Hospital
NCT03549572
In-Field Detection of Intracranial Pressure
Duke University
NCT04515212
Non-Interventional F-Two Isoprostane Trial (NIFTI)
University of Texas Southwestern Medical Center
NCT00505908
Detection of Hemodynamic Changes in TBI Population With Functional Near Infrared Spectroscopy
Uniformed Services University of the Health Sciences
NCT01797549
"Interactive Metronome Technology for Blast-Related Traumatic Brain Injury"
The Defense and Veterans Brain Injury Center
NCT01248390
Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury
The University of Texas Health Science Center, Houston
NCT01851083
ACTIVE: Activity Therapy to Increase Veteran Engagement
VA Office of Research and Development
NCT04976621
Neural Basis of Decision-Making Deficits in Traumatic Brain Injury
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02169310
Training to Reconnect With Emotional Awareness Therapy
Indiana University
NCT03414463
Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness
Gaylord Hospital
NCT04930822
Addressing Attitudes to Improve Use of Protective Headwear in Older Adults
University of California, Los Angeles
NCT01582464
rTMS for Cognitive Rehabilitation After TBI
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03642158
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 12 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Traumatic Brain Injury records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Traumatic Brain Injury trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Traumatic Brain Injury page
172 registered trials, 75 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 75 Traumatic Brain Injury trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Traumatic Brain Injury trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Traumatic Brain Injury condition card totals 172 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.