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Traumatic Brain Injury clinical trials
75 of 172 indexed Traumatic Brain Injury trials are currently recruiting.
172 US clinical trials · 75 currently recruiting
Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
The research picture
Traumatic Brain Injury has 172 registered US clinical trials, 75 of them open to new participants right now, about 44% of the total.
- 75
- recruiting participants now
- 44%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 11
- top sponsor: VA Office of Research and Development
Active & Recent Trials
172 total, page 3 of 4
Prehospital Tranexamic Acid Use for Traumatic Brain Injury
University of Washington
NCT01990768
Evaluation of Mild TBI in Collegiate Athletes
Banyan Biomarkers
NCT02189525
Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing
University of Washington
NCT00194441
Neural Markers and Rehabilitation of Executive Functioning in Veterans With Traumatic Brain Injury and Posttraumatic Stress Disorder
University of North Carolina, Chapel Hill
NCT01410721
An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans
VA Eastern Colorado Health Care System
NCT01502436
Evaluation of an Intervention Model for Family Crisis and Support
Virginia Commonwealth University
NCT00205530
Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder
Wave Neuroscience
NCT02990793
Effects of Aerobic Exercise on Cognition, Mood and Fatigue Following TBI
Icahn School of Medicine at Mount Sinai
NCT00619463
Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study
Children's Hospital Medical Center, Cincinnati
NCT01042899
Spreading Depolarizations in Traumatic Brain Injury
University of Cincinnati
NCT03379220
Online Emotion Regulation Group Intervention
Icahn School of Medicine at Mount Sinai
NCT03479606
Internet-Based Treatment for Children With Traumatic Brain Injuries & Their Families: Counselor Assisted Problem Solving
Children's Hospital Medical Center, Cincinnati
NCT00409448
Evaluation OF Biomarkers OF Traumatic Brain Injury Extension Study
Banyan Biomarkers
NCT02439736
SMS Messaging to Reduce Depression and Anxiety Following TBI
Albert Einstein Healthcare Network
NCT02061553
Internet-based Interacting Together Everyday, Recovery After Childhood TBI (I-InTERACT)--RRTC
Children's Hospital Medical Center, Cincinnati
NCT01214694
Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study
University of Alabama at Birmingham
NCT03797378
Personalized, Augmented Cognitive Training (PACT) for Service Members and Veterans with a History of TBI
Veterans Medical Research Foundation
NCT04560946
Acute Cognitive and Neurobehavioral Intervention: Efficacy Evaluation
Virginia Commonwealth University
NCT00205569
Estimating Brain Biomechanics Using MRI
National Institutes of Health Clinical Center (CC)
NCT01633268
Measure of Cerebrovascular Dysfunction After TBI With fNIRS
Uniformed Services University of the Health Sciences
NCT01789164
Approaches to Auditory Rehabilitation for Mild Traumatic Brain Injury
US Department of Veterans Affairs
NCT00930774
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
VA Office of Research and Development
NCT01670526
Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury
Baylor College of Medicine
NCT00704379
Improving Health Outcomes With Resource Facilitation
Rehabilitation Hospital of Indiana
NCT04462549
Improving Family Quality of Life Through Training to Reduce Care-Resistant Behaviors by People With AD and TBI
University of Alabama at Birmingham
NCT03734289
Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury
Posit Science Corporation
NCT01640158
Telerehabilitation for OIF/OEF Returnees With Combat-Related Traumatic Brain Injury
VA Office of Research and Development
NCT00676182
Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment
Kessler Foundation
NCT02020564
The Effect of Exercise on Mood After Traumatic Brain Injury
University of Washington
NCT00571545
Improving Executive Functions After Traumatic Brain Injury (TBI): A Clinical Trial of the "Executive Plus" Program
Icahn School of Medicine at Mount Sinai
NCT00233129
A Health & Wellness Intervention for Individuals With Traumatic Brain Injury (TBI)
VA Eastern Colorado Health Care System
NCT01334398
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
VA Office of Research and Development
NCT02391402
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
The University of Texas Medical Branch, Galveston
NCT03554265
Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression
Wake Forest University Health Sciences
NCT00621751
Geri-TBI: A Prospective Multi-center Evaluation of Geriatric Patients With Traumatic Brain Injury
Methodist Health System
NCT05171010
MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury
University of California, San Francisco
NCT01298557
Functional Connectivity as a Biomarker of rTMS
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03050801
Efficacy Study of Strattera for Treating Attention Disorders in Traumatic Brain Injury (TBI)
Craig Hospital
NCT00702364
Validity and Feasibility of the CRSR-FAST
Massachusetts General Hospital
NCT03549572
In-Field Detection of Intracranial Pressure
Duke University
NCT04515212
Non-Interventional F-Two Isoprostane Trial (NIFTI)
University of Texas Southwestern Medical Center
NCT00505908
Detection of Hemodynamic Changes in TBI Population With Functional Near Infrared Spectroscopy
Uniformed Services University of the Health Sciences
NCT01797549
"Interactive Metronome Technology for Blast-Related Traumatic Brain Injury"
The Defense and Veterans Brain Injury Center
NCT01248390
Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury
The University of Texas Health Science Center, Houston
NCT01851083
ACTIVE: Activity Therapy to Increase Veteran Engagement
VA Office of Research and Development
NCT04976621
Neural Basis of Decision-Making Deficits in Traumatic Brain Injury
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02169310
Training to Reconnect With Emotional Awareness Therapy
Indiana University
NCT03414463
Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness
Gaylord Hospital
NCT04930822
Addressing Attitudes to Improve Use of Protective Headwear in Older Adults
University of California, Los Angeles
NCT01582464
rTMS for Cognitive Rehabilitation After TBI
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03642158
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 12 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Traumatic Brain Injury Trial Landscape
172 indexed Traumatic Brain Injury studies · 75 recruiting (44%).
Phase mix: 5 late (III/IV) vs 23 early (I/II).
Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Traumatic Brain Injury?
PlainTrial tracks 172 US clinical trials for Traumatic Brain Injury, of which 75 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Traumatic Brain Injury?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.