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ClinicalTrials.gov 75 recruiting now official registry

Traumatic Brain Injury clinical trials

75 of 172 indexed Traumatic Brain Injury trials are currently recruiting.

172 US clinical trials · 75 currently recruiting

Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.

The research picture

Traumatic Brain Injury has 172 registered US clinical trials, 75 of them open to new participants right now, about 44% of the total.

75
recruiting participants now
44%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
11
top sponsor: VA Office of Research and Development
Phase 111Phase 212Phase 33Phase 42

Active & Recent Trials

172 total, page 3 of 4

COMPLETED Phase 2 967 participants

Prehospital Tranexamic Acid Use for Traumatic Brain Injury

University of Washington

NCT01990768

COMPLETED 500 participants

Evaluation of Mild TBI in Collegiate Athletes

Banyan Biomarkers

NCT02189525

COMPLETED NA 260 participants

Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing

University of Washington

NCT00194441

COMPLETED NA 241 participants

Neural Markers and Rehabilitation of Executive Functioning in Veterans With Traumatic Brain Injury and Posttraumatic Stress Disorder

University of North Carolina, Chapel Hill

NCT01410721

COMPLETED 230 participants

An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans

VA Eastern Colorado Health Care System

NCT01502436

COMPLETED 160 participants

Evaluation of an Intervention Model for Family Crisis and Support

Virginia Commonwealth University

NCT00205530

COMPLETED NA 158 participants

Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder

Wave Neuroscience

NCT02990793

COMPLETED NA 154 participants

Effects of Aerobic Exercise on Cognition, Mood and Fatigue Following TBI

Icahn School of Medicine at Mount Sinai

NCT00619463

COMPLETED NA 153 participants

Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study

Children's Hospital Medical Center, Cincinnati

NCT01042899

COMPLETED 147 participants

Spreading Depolarizations in Traumatic Brain Injury

University of Cincinnati

NCT03379220

COMPLETED NA 137 participants

Online Emotion Regulation Group Intervention

Icahn School of Medicine at Mount Sinai

NCT03479606

COMPLETED NA 132 participants

Internet-Based Treatment for Children With Traumatic Brain Injuries & Their Families: Counselor Assisted Problem Solving

Children's Hospital Medical Center, Cincinnati

NCT00409448

COMPLETED 119 participants

Evaluation OF Biomarkers OF Traumatic Brain Injury Extension Study

Banyan Biomarkers

NCT02439736

COMPLETED NA 119 participants

SMS Messaging to Reduce Depression and Anxiety Following TBI

Albert Einstein Healthcare Network

NCT02061553

COMPLETED NA 117 participants

Internet-based Interacting Together Everyday, Recovery After Childhood TBI (I-InTERACT)--RRTC

Children's Hospital Medical Center, Cincinnati

NCT01214694

COMPLETED NA 108 participants

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study

University of Alabama at Birmingham

NCT03797378

COMPLETED NA 107 participants

Personalized, Augmented Cognitive Training (PACT) for Service Members and Veterans with a History of TBI

Veterans Medical Research Foundation

NCT04560946

COMPLETED 103 participants

Acute Cognitive and Neurobehavioral Intervention: Efficacy Evaluation

Virginia Commonwealth University

NCT00205569

COMPLETED 101 participants

Estimating Brain Biomechanics Using MRI

National Institutes of Health Clinical Center (CC)

NCT01633268

COMPLETED 100 participants

Measure of Cerebrovascular Dysfunction After TBI With fNIRS

Uniformed Services University of the Health Sciences

NCT01789164

COMPLETED NA 99 participants

Approaches to Auditory Rehabilitation for Mild Traumatic Brain Injury

US Department of Veterans Affairs

NCT00930774

COMPLETED Phase 3 94 participants

Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI

VA Office of Research and Development

NCT01670526

COMPLETED Phase 2 94 participants

Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury

Baylor College of Medicine

NCT00704379

COMPLETED NA 90 participants

Improving Health Outcomes With Resource Facilitation

Rehabilitation Hospital of Indiana

NCT04462549

COMPLETED NA 88 participants

Improving Family Quality of Life Through Training to Reduce Care-Resistant Behaviors by People With AD and TBI

University of Alabama at Birmingham

NCT03734289

COMPLETED NA 86 participants

Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury

Posit Science Corporation

NCT01640158

COMPLETED 81 participants

Telerehabilitation for OIF/OEF Returnees With Combat-Related Traumatic Brain Injury

VA Office of Research and Development

NCT00676182

COMPLETED NA 80 participants

Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment

Kessler Foundation

NCT02020564

COMPLETED NA 78 participants

The Effect of Exercise on Mood After Traumatic Brain Injury

University of Washington

NCT00571545

COMPLETED NA 77 participants

Improving Executive Functions After Traumatic Brain Injury (TBI): A Clinical Trial of the "Executive Plus" Program

Icahn School of Medicine at Mount Sinai

NCT00233129

COMPLETED 74 participants

A Health & Wellness Intervention for Individuals With Traumatic Brain Injury (TBI)

VA Eastern Colorado Health Care System

NCT01334398

COMPLETED NA 73 participants

Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD

VA Office of Research and Development

NCT02391402

COMPLETED Phase 3 72 participants

Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy

The University of Texas Medical Branch, Galveston

NCT03554265

COMPLETED NA 70 participants

Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression

Wake Forest University Health Sciences

NCT00621751

COMPLETED 69 participants

Geri-TBI: A Prospective Multi-center Evaluation of Geriatric Patients With Traumatic Brain Injury

Methodist Health System

NCT05171010

COMPLETED 69 participants

MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury

University of California, San Francisco

NCT01298557

COMPLETED Phase 1 68 participants

Functional Connectivity as a Biomarker of rTMS

National Institute of Neurological Disorders and Stroke (NINDS)

NCT03050801

COMPLETED NA 60 participants

Efficacy Study of Strattera for Treating Attention Disorders in Traumatic Brain Injury (TBI)

Craig Hospital

NCT00702364

COMPLETED 56 participants

Validity and Feasibility of the CRSR-FAST

Massachusetts General Hospital

NCT03549572

COMPLETED NA 53 participants

In-Field Detection of Intracranial Pressure

Duke University

NCT04515212

COMPLETED 50 participants

Non-Interventional F-Two Isoprostane Trial (NIFTI)

University of Texas Southwestern Medical Center

NCT00505908

COMPLETED 50 participants

Detection of Hemodynamic Changes in TBI Population With Functional Near Infrared Spectroscopy

Uniformed Services University of the Health Sciences

NCT01797549

COMPLETED NA 48 participants

"Interactive Metronome Technology for Blast-Related Traumatic Brain Injury"

The Defense and Veterans Brain Injury Center

NCT01248390

COMPLETED Phase 2 47 participants

Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury

The University of Texas Health Science Center, Houston

NCT01851083

COMPLETED NA 46 participants

ACTIVE: Activity Therapy to Increase Veteran Engagement

VA Office of Research and Development

NCT04976621

COMPLETED Phase 1 45 participants

Neural Basis of Decision-Making Deficits in Traumatic Brain Injury

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02169310

COMPLETED NA 44 participants

Training to Reconnect With Emotional Awareness Therapy

Indiana University

NCT03414463

COMPLETED NA 37 participants

Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness

Gaylord Hospital

NCT04930822

COMPLETED 37 participants

Addressing Attitudes to Improve Use of Protective Headwear in Older Adults

University of California, Los Angeles

NCT01582464

COMPLETED NA 34 participants

rTMS for Cognitive Rehabilitation After TBI

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT03642158

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Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 12
Phase 3 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Traumatic Brain Injury Trial Landscape

172 indexed Traumatic Brain Injury studies · 75 recruiting (44%).

Phase mix: 5 late (III/IV) vs 23 early (I/II).

Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Traumatic Brain Injury?

PlainTrial tracks 172 US clinical trials for Traumatic Brain Injury, of which 75 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Traumatic Brain Injury?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.