Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury

Study Summary

Various methods have been studied to evaluate autoregulation. However, there is currently no universally accepted technique to assess integrity of the cerebral autoregulation neurovascular system. In the last decade, significant progress has been achieved in developing methods to assess cerebral autoregulation by quantifying cross-correlation between spontaneous oscillations in CBF or oxygenation and similar oscillations in arterial blood pressure. In this study the investigators will analyze the relationship between spontaneous fluctuations in mean arterial blood pressure and cerebral blood flow velocity or cerebral regional oxygenation to investigate two novel methods for measuring cerebral autoregulation, Transfer Function Analysis and Wavelet Coherence after acute pediatric brain injury.

Primary Outcome

The transfer function has three components: I. Gain: This measures the magnitude of transmission of MAP oscillations to CBFv. Effectively, a functional dCA system dampens the strength of transmitted oscillations resulting in a lower gain value. A higher gain value is therefore suggestive of impaired autoregulation. II. Phase is a "time delay" in degrees measured between the two waveforms. Absence of autoregulation would result in both MAP and CBFV changing at the same time. This would be measu

Conditions Studied

Interventions

• DEVICE Transcranial Doppler

Study Locations (1)