Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07357090 · ClinicalTrials.gov registry record · NA
Carbon Dioxide Administration and Brain Waste Clearance
A NA study of Traumatic Brain Injury and Aging Disorder, sponsored by Andrew Mayer.
- Recruiting
- Registry status
- NA
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT07357090: Recruiting NA study of Traumatic Brain Injury and Aging Disorder, sponsored by Andrew Mayer.
NCT07357090 is a NA study of Traumatic Brain Injury and Aging Disorder that is actively recruiting participants, run by Andrew Mayer. The registered enrollment target is 200 participants, below the 276-participant average among 171 other Traumatic Brain Injury trials with a reported enrollment target (28% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07357090, a NA study of Traumatic Brain Injury and Aging Disorder, is actively recruiting participants, sponsored by Andrew Mayer.
- RECRUITING
- Registry status
- NA
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a counter-balanced design, in which individuals with and without a history of traumatic brain injury (TBI) will receive different levels of CO2 (targeted changes of approximately 5 or 10 mmHG in end-tidal CO2) approximately one week apart. The counter-balanced design means that each participant receives a single dose of CO2 at each visit, and different doses of CO2 at each visit. The order in which participants receive the dose is randomized, and the participant will not be informed of the dose.
Primary Outcome
Cerebrovascular reactivity (CVR) will be quantified using time-shifted end-tidal carbon dioxide (ETCO₂) regressors to model blood oxygen level-dependent (BOLD) changes using functional magnetic resonance imaging, capturing the temporally lagged positive relationship between ETCO₂ and the BOLD signal. Vascular enhanced changes in bulk CSF flow will be assessed by regressing band-pass filtered global grey matter signals and their derivatives on CSF bulk flow to capture the temporally lagged, negat
Conditions Studied
Interventions
- OTHER Hypercapnia task performed during fMRI
Study Locations (1)
New Mexico
- The Mind Research Network - Albuquerque
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2026-04 |
| Est. Completion | 2032-02 |
| Phase | NA |
What NCT07357090 shows while recruiting
NCT07357090 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 276-participant average among 171 other Traumatic Brain Injury trials with a reported enrollment target (28% lower).
The record links to 3 conditions, with Traumatic Brain Injury appearing as the primary indexed condition, and to 1 intervention - of which Hypercapnia task performed during fMRI is the first listed.
NCT07357090 reports a single indexed study location in New Mexico.
Frequently Asked Questions
What is clinical trial NCT07357090 about?
NCT07357090 is a clinical study titled "Carbon Dioxide Administration and Brain Waste Clearance". The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a...
What is the current status of trial NCT07357090?
This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2026-04. Estimated completion is 2032-02.
What conditions does trial NCT07357090 study?
This clinical trial studies the following conditions: Traumatic Brain Injury, Aging Disorder, Magnetic Resonance Imaging (MRI).
What interventions are being tested in trial NCT07357090?
The interventions under investigation include: Hypercapnia task performed during fMRI (OTHER).
Who is sponsoring clinical trial NCT07357090?
This trial is sponsored by Andrew Mayer, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07357090 being conducted?
This trial has 1 study location across New Mexico. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Traumatic Brain Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07357090's enrollment target sits among peer trials
200 33rd of 171 higher than 137 of 171 other Traumatic Brain Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Traumatic Brain Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
tPBM in Older Adults With Traumatic Brain Injury
RECRUITING · NA
-
TMS-fNIRS Personalized Dosing
RECRUITING · NA
-
Community-based Implementation of Online EmReg
RECRUITING · NA
-
Evaluation of the Abbott i-STAT TBI Biomarker Test
RECRUITING · NA
-
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
RECRUITING · NA
-
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00107289 · 200 participants · Phase 2
Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma
- NCT00109174 · 200 participants · NA
MRS Measurement of Glutamate and GABA Metabolism in Brain
- NCT00177268 · 200 participants
Blood, Urine, and Tissue Collection for Cutaneous Lymphoma, Eczema, and Atopic Dermatitis Research
- NCT00493688 · 200 participants
A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia