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NCT05337618 · ClinicalTrials.gov registry record · Phase 2

Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)

A Phase 2 study of Traumatic Brain Injury, sponsored by University of Cincinnati.

Recruiting
Registry status
Phase 2
Development phase
72
Enrollment target
1
Study location

NCT05337618 is a Phase 2 study of Traumatic Brain Injury that is actively recruiting participants, run by University of Cincinnati. The registered enrollment target is 72 participants, below the 277-participant average among 171 other Traumatic Brain Injury trials with a reported enrollment target (74% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05337618, a Phase 2 study of Traumatic Brain Injury, is actively recruiting participants, sponsored by University of Cincinnati.

RECRUITING
Registry status
Phase 2
Development phase
72 participants
Enrollment target
1
Study location

Study Summary

This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have undergone acute operative treatment of severe traumatic brain injury.

Conditions Studied

Traumatic Brain Injury

Interventions

  • DIAGNOSTIC_TEST Full-band Electrocorticography
  • COMBINATION_PRODUCT Treatment Algorithm

Study Locations (1)

Ohio

  • University of Cincinnati - Cincinnati

Trial Details

FieldValue
Enrollment Target 72 participants
Start Date 2022-12-16
Est. Completion 2027-03-20
Phase Phase 2

Sponsor

University of Cincinnati

245 total trials

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What the Registry Record Tells You About NCT05337618

The ClinicalTrials.gov registry entry for NCT05337618 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 72 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 277-participant average among 171 other Traumatic Brain Injury trials with a reported enrollment target (74% lower). The listed sponsor is University of Cincinnati, which has 245 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Traumatic Brain Injury appearing as the primary indexed condition, and to 2 interventions - of which Full-band Electrocorticography is the first listed.

NCT05337618 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT05337618 about?

NCT05337618 is a clinical study titled "Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)". This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have undergo...

What is the current status of trial NCT05337618?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 72 participants. The study started on 2022-12-16. Estimated completion is 2027-03-20.

What conditions does trial NCT05337618 study?

This clinical trial studies the following conditions: Traumatic Brain Injury.

What interventions are being tested in trial NCT05337618?

The interventions under investigation include: Full-band Electrocorticography (DIAGNOSTIC_TEST), Treatment Algorithm (COMBINATION_PRODUCT).

Who is sponsoring clinical trial NCT05337618?

This trial is sponsored by University of Cincinnati, which has 245 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05337618 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.