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ClinicalTrials.gov 64 recruiting now official registry

Stress clinical trials

64 of 153 indexed Stress trials are currently recruiting.

153 US clinical trials · 64 currently recruiting

Stress is the subject of 153 registered US clinical trials on ClinicalTrials.gov, 64 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is Virginia Commonwealth University, running 5 of these trials.

The research picture

Stress has 153 registered US clinical trials, 64 of them open to new participants right now, about 42% of the total.

64
recruiting participants now
42%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
5
top sponsor: Virginia Commonwealth University
Phase 16Phase 26Phase 42

Active & Recent Trials

153 total, page 2 of 4

RECRUITING NA 40 participants

Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students

Milton S. Hershey Medical Center

NCT07240792

RECRUITING NA 40 participants

Feasibility of Virtual Tai Chi Easy for Registered Nurses

University of Arizona

NCT06423638

RECRUITING Phase 2 40 participants

Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder

Mclean Hospital

NCT05837104

RECRUITING NA 36 participants

The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

Massachusetts General Hospital

NCT04505865

RECRUITING Phase 2 32 participants

Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia

University of Nebraska

NCT06364228

RECRUITING 30 participants

Surviving Daily Life

Thomas Jefferson University

NCT07054723

RECRUITING NA 30 participants

Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

Massachusetts General Hospital

NCT04496947

RECRUITING NA 30 participants

Depression, Aging, Stress and Heart Health Study

University of North Carolina, Chapel Hill

NCT05570721

RECRUITING NA 30 participants

Effects of Body Composition on Vascular Health in Females with a Healthy Body Weight

Ball State University

NCT06818500

RECRUITING NA 30 participants

The Effects of Daily Polyvagal Exercises on Stress in Students of Physical Therapy

Dominican University New York

NCT06557083

RECRUITING NA 24 participants

ACT for HIV-Positive Men

University of Alabama at Birmingham

NCT06625437

RECRUITING Phase 1 20 participants

Impact of OnabotulinumtoxinA (BOTOX®) on Stress

Center for Advanced Facial Plastic Surgery

NCT06778421

RECRUITING NA 20 participants

Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress

Baylor University

NCT07138443

RECRUITING 15 participants

Applied Clinical Neuroscience and Its Effect on Self-reported Stress and Other Physiological Markers

Dylan Saulsbery

NCT06358560

ACTIVE NOT RECRUITING NA 521 participants

Caring for Vets and Service Members: Caring Contacts for Stressed and Distressed Veterans and Service Members

University of Washington

NCT06136234

ACTIVE NOT RECRUITING NA 505 participants

Evaluating Stress Management Among Allogeneic HCT Caregivers

H. Lee Moffitt Cancer Center and Research Institute

NCT05078229

ACTIVE NOT RECRUITING NA 360 participants

Wellbeing of the ECE Workforce in Low-resourced Locations

Colorado School of Public Health

NCT05416216

ACTIVE NOT RECRUITING NA 150 participants

Stress Reduction After Use of a Haptic Vibrotactile Trigger Technology Patch: Analysis and Assessment

SuperPatch Limited

NCT06708715

ACTIVE NOT RECRUITING NA 120 participants

Evaluating Stress Management Strategies Within the School Readiness Parenting Program

Florida International University

NCT06626750

ACTIVE NOT RECRUITING NA 117 participants

This Study Explores the Mental Health Impact of Two Akashic Records Sessions.

Rasa Healing

NCT07219914

ACTIVE NOT RECRUITING NA 104 participants

Effects of a Theanine for Stress Relief Formulation in Individuals Who Report Occasional Moderate High Levels of Stress.

Supplement Formulators

NCT05854017

ACTIVE NOT RECRUITING NA 90 participants

Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention

Women and Infants Hospital of Rhode Island

NCT06365645

ACTIVE NOT RECRUITING NA 80 participants

Disrupted Connections: The Impact of Acute Stress on Memory Integration

Nevada State University

NCT07055555

ACTIVE NOT RECRUITING Phase 4 75 participants

Predictors of Cognitive Outcomes in Geriatric Depression

David Steffens

NCT05273996

ACTIVE NOT RECRUITING NA 40 participants

The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT

University of Florida

NCT06580067

ACTIVE NOT RECRUITING NA 40 participants

Effect of Black Cumin Seed Oil Supplementation on Cortisol, Stress and Mood

Shawn Talbott

NCT06950424

ACTIVE NOT RECRUITING NA 40 participants

A Clinical Trial to Evaluate the Effects of a Herbal Tincture on Energy Levels, Weight Management, and Markers of Metabolic Health

Apothekary

NCT06949540

COMPLETED NA 8,519 participants

A Study on Prevalence, Protection and Recovery From COVID-19 in Seasoned Yoga Practitioners in Comparison to Age and Gender Matched Controls

Beth Israel Deaconess Medical Center

NCT04498442

COMPLETED NA 6,500 participants

Mental Health Pathways in Internet Support Groups

Carnegie Mellon University

NCT02396472

COMPLETED NA 4,370 participants

SSIs for Mental Health and Loneliness

University of California, Irvine

NCT05687162

COMPLETED NA 597 participants

Incentivizing Meditation App Habit Formation

Arizona State University

NCT05217602

COMPLETED NA 522 participants

Project SOLVE: Trial of a Brief Digital Problem-solving Intervention

Harvard University

NCT04806321

COMPLETED NA 356 participants

Parenting Young Children Study

University of Oregon

NCT05180487

COMPLETED NA 333 participants

Bundle Consent and Expectation Setting in Pediatric Intensive Care Unit

Virginia Commonwealth University

NCT04697173

COMPLETED NA 324 participants

Daily Assessment of Mood and Social Media Behaviors Study

Southern Methodist University

NCT04349423

COMPLETED Phase 2 268 participants

Personal Relevance of Psychotherapy for Asian Americans

IRIS Media

NCT06632158

COMPLETED Phase 1 256 participants

Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures

University of Michigan

NCT01673087

COMPLETED NA 226 participants

Intervention Trial to Reduce Mental Health Disparities in Latina Immigrant Women

University of Washington

NCT03545282

COMPLETED Phase 2 212 participants

Personalized Trials for Stress Management Against Standard of Care

Northwell Health

NCT05408832

COMPLETED NA 192 participants

Coherence Training for Military Personnel

United States Naval Medical Center, San Diego

NCT01599598

COMPLETED 178 participants

Physiological Responses in Tobacco Chippers

Oregon Health and Science University

NCT01237834

COMPLETED NA 176 participants

A Study to Assess the Effects of Dietary Supplement Drinks on Sleep, Stress and Mood

The Water Street Collective

NCT06378567

COMPLETED NA 175 participants

Life Enhancing Activities for Family Caregivers

University of California, San Francisco

NCT01825681

COMPLETED NA 174 participants

Mindfulness Takes Practice

Arizona State University

NCT04378530

COMPLETED NA 167 participants

Strong People Strength Training Study

Cornell University

NCT04203563

COMPLETED NA 165 participants

Hostile Bias Modification Training (HBMT) Study

Walter Reed Army Institute of Research (WRAIR)

NCT04997356

COMPLETED NA 160 participants

Strategies for Responding to Stress

University of Texas at Austin

NCT03289156

COMPLETED NA 150 participants

Brain and Meditation (BAM) Study

University of Wisconsin, Madison

NCT05215314

COMPLETED NA 140 participants

Efficacy of the Tony Robbins Rapid Planning Method (RPM)

Applied Science & Performance Institute

NCT06539949

COMPLETED 139 participants

Web-based Patient Reported Outcome Measurement Information System (PROMIS ) to Explore Burden and Stress in Cancer Caregivers (BaSiC2)

National Institutes of Health Clinical Center (CC)

NCT01981538

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 6
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stress Trial Landscape

153 indexed Stress studies · 64 recruiting (42%).

Phase mix: 2 late (III/IV) vs 12 early (I/II).

Top sponsor: Virginia Commonwealth University (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stress?

PlainTrial tracks 153 US clinical trials for Stress, of which 64 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stress?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.