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ClinicalTrials.gov 64 recruiting now official registry

Stress clinical trials

64 of 153 indexed Stress trials are currently recruiting.

153 US clinical trials · 64 currently recruiting

Stress is the subject of 153 registered US clinical trials on ClinicalTrials.gov, 64 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is Virginia Commonwealth University, running 5 of these trials.

The research picture

Stress has 153 registered US clinical trials, 64 of them open to new participants right now, about 42% of the total.

64
recruiting participants now
42%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
5
top sponsor: Virginia Commonwealth University
Phase 16Phase 26Phase 42

Active & Recent Trials

153 total, page 3 of 4

COMPLETED NA 128 participants

Clinical Trial of a Supporter-Targeted Intervention to Improve Outcomes in Recent Sexual Assault Survivors

University of Washington

NCT05345405

COMPLETED NA 120 participants

Natural Modulators of Immune Function and Mood

3 Waves Wellness

NCT05508529

COMPLETED 120 participants

Chronic Alcohol and Brain Stress Circuit Response

Yale University

NCT01031264

COMPLETED NA 120 participants

A Study to Evaluate the Effect of SlimBiotics Probiotic Formula on Weight Management and Metabolic Health Outcomes

Slimbiotics

NCT05917314

COMPLETED NA 112 participants

Mindfulness Training in the Medical Health Care System

University of Miami

NCT06003699

COMPLETED Phase 1 112 participants

Decreasing Stress and Improving Self-control With "Stress in Control" (Sync) Training

Yale University

NCT01721499

COMPLETED Phase 4 109 participants

VSMART (Video-Conference Stress Management and Relaxation Training for Older Women With Breast Cancer)

University of Miami

NCT03955991

COMPLETED NA 99 participants

Breathing Interventions for Relaxation: Dosing Through Extended Exhale

Vanderbilt University Medical Center

NCT02870868

COMPLETED NA 98 participants

Evaluation Study of Talk Parenting Skills

Oregon Research Behavioral Intervention Strategies

NCT04633434

COMPLETED NA 94 participants

Building Resiliency Among Caregivers of Curvivors and Metavivors

Massachusetts General Hospital

NCT05702723

COMPLETED 88 participants

Brain Mechanisms of Emotion and Motivation: A Mind-Body Study

Mclean Hospital

NCT01850472

COMPLETED NA 83 participants

The Effect of Psychotherapy on Stress Biochemistry: An RCT of Psychotherapy and Emotional Freedom Techniques (EFT)

Soul Medicine Institute

NCT00641394

COMPLETED NA 75 participants

A Randomized-Controlled Trial to Investigate the Effect of a Novel Music Therapy Application to Reduce Anxiety and Stress

SoundMind

NCT06021821

COMPLETED NA 74 participants

Effect of an 8-week Heartfulness Meditation Program on Burnout and Stress at Veterinary Specialty Hospital

Heartfulness Institute

NCT06338098

COMPLETED NA 74 participants

Effectiveness of Music Practical Examinations

Russell Sage College

NCT06187272

COMPLETED NA 74 participants

Family Promoting Positive Emotions Pilot Study

Vanderbilt University

NCT05223842

COMPLETED NA 70 participants

Health Enhancement And Resilience Training

University of California, San Francisco

NCT01959126

COMPLETED NA 70 participants

Meditation for NICU Moms

St. Louis University

NCT03574766

COMPLETED NA 64 participants

Effects of Open-label Placebos on COVID-related Psychological Health

Michigan State University

NCT05035550

COMPLETED NA 64 participants

Mindfulness, Yoga, and Cardiovascular Disease

The Cleveland Clinic

NCT00696852

COMPLETED NA 60 participants

The Effect of Music-Based Mindfulness to Cope with Acculturative-Related Stress

University of Miami

NCT06166732

COMPLETED NA 57 participants

Mindfulness Practices for Healthcare Professional Trainees

Virginia Commonwealth University

NCT03403335

COMPLETED Phase 1 56 participants

The Effects of Smell on Mood and Physical Responses

National Center for Complementary and Integrative Health (NCCIH)

NCT00097253

COMPLETED NA 53 participants

Internet and Telephone Support Intervention for Stroke Caregivers

VA Office of Research and Development

NCT04348851

COMPLETED NA 53 participants

Mindful Kala: Virtual Bharatanatyam Wellness Program for Students

Yale University

NCT04745364

COMPLETED NA 53 participants

Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity

University of California, San Francisco

NCT04606199

COMPLETED 53 participants

Neurophysiology, Estrogen, and Stress Exposure in the Emergence of Depression in Adolescent Girls

University of North Carolina, Chapel Hill

NCT03450135

COMPLETED NA 52 participants

Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)

University of Cincinnati

NCT04404478

COMPLETED 52 participants

Seasonal Patterns of Stress, Diet and Physical Activity - Life in All Seasons (LENAS)

USDA Grand Forks Human Nutrition Research Center

NCT01674296

COMPLETED NA 50 participants

Stress Management Intervention in Women's Heart Clinic, Heart SMART Program

Mayo Clinic

NCT02670421

COMPLETED NA 50 participants

Ashwagandha Extract for Weight and Stress Management in Overweight and Obese Adults

SF Research Institute

NCT07215455

COMPLETED NA 47 participants

A Trauma-Informed Approach for Positive Youth Development for Montana Students

Montana State University

NCT04664855

COMPLETED NA 46 participants

The Feasibility of the PAINReportIt Guided Relaxation Intervention-INPATIENT

University of Florida

NCT02729350

COMPLETED NA 38 participants

Investigating the Detection of Bovine and Soy Proteins in Human Milk

University of Idaho

NCT04851340

COMPLETED NA 38 participants

Mindfulness-Music Intervention for Adolescents and Young Adults With Cancer

Dana-Farber Cancer Institute

NCT03709225

COMPLETED NA 37 participants

Mindfulness-Based Stress Reduction for Metro Nashville Public School Employees

Vanderbilt University Medical Center

NCT05051969

COMPLETED NA 35 participants

Study to Evaluate the Efficacy of Asystems' Complete Calm Supplementation on Sleep Quality and Duration, Anxiety, and Stress

Asystem

NCT05190640

COMPLETED NA 33 participants

Digital Interventions to Treat Hazardous Drinking

Yale University

NCT04890652

COMPLETED NA 32 participants

SmartManage Stress Management for HIV+ Cancer Survivors

University of Miami

NCT04544917

COMPLETED NA 31 participants

Project MiCRIM- Sleep and Stress Intervention

Florida State University

NCT05384067

COMPLETED NA 30 participants

A Mixed Methods Evaluation of HPI Resilience Intervention Study

Johnson & Johnson Health and Wellness Solutions

NCT03451240

COMPLETED NA 28 participants

Does Mindfulness Training Change the Processing of Social Threat?

Massachusetts General Hospital

NCT00992875

COMPLETED NA 28 participants

Stress Management and Resiliency Training (SMART) for Family Medicine Residents at Eglin AFB

Laura Rhaney

NCT03936114

COMPLETED NA 21 participants

Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families

University of California, Los Angeles

NCT05612685

COMPLETED NA 20 participants

Virtual Reality Experience for Stress Reduction in Cardiology Patients

University of California, Los Angeles

NCT04984655

COMPLETED NA 20 participants

Art for Hearts/Black Women's Hearts Paint Night

Virginia Commonwealth University

NCT05252507

COMPLETED NA 18 participants

Parenting Young Children in Pediatrics

University of Oregon

NCT06273228

COMPLETED NA 13 participants

KickStart30: A 30-Day Intervention for Patients With Rheumatoid Arthritis (RA)

University of Texas at Austin

NCT03993548

COMPLETED Phase 2 13 participants

Efficacy of Healing Touch in Stressed Neonates

National Center for Complementary and Integrative Health (NCCIH)

NCT00034008

COMPLETED NA 10 participants

First Responder Resiliency Program During COVID-19

Mayo Clinic

NCT04536376

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 6
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stress Trial Landscape

153 indexed Stress studies · 64 recruiting (42%).

Phase mix: 2 late (III/IV) vs 12 early (I/II).

Top sponsor: Virginia Commonwealth University (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stress?

PlainTrial tracks 153 US clinical trials for Stress, of which 64 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stress?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.