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ClinicalTrials.gov 73 recruiting now early-phase tilt #74 of 28,707 conditions

Sleep: early-phase trial registry

73 of 152 indexed Sleep trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #74 of 28,707 conditions by registered trial count.

152 US clinical trials · 73 currently recruiting · #74 of 28,707 conditions by registered trial count

Sleep: 152 US clinical trials tracked, 73 recruiting.

Sleep is the subject of 152 registered US clinical trials on ClinicalTrials.gov, 73 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is University of Pittsburgh, running 10 of these trials.

Enrollment posture brief

Registry condition sleep

OPEN 73 | RECR 48% | LATE 7 | EARLY 15 | RANK #74 | SPON 10

Nearest open-share peer: Alpha-1 Antitrypsin Deficiency (48% recruiting · 25 trials)

Cervical Cancer48.3%Sleep (this)48%Stress41.8%Insomnia40.8%Atopic Dermatitis36.4%
Open-enrollment share among volume-matched conditions near Sleep

Sleep lists 73 open slots (48% of 152 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Sleep on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Sleep is recruiting above its size-band peers.

    73 of 152 indexed trials (48%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Sleep trials is spread across many organizations.

    University of Pittsburgh accounts for 10 of 152 trials (6.6%). 96 distinct sponsors appear on at least one study for this condition label.

  3. Typical Sleep enrolment sits around 80 participants.

    Median target enrolment is 80 among the 152 trials that report a genuine target (sentinel values excluded). 84 of those (55.3%) plan for fewer than 100 participants.

  4. Sleep research is mostly interventional.

    134 interventional and 18 observational studies make up this index (88.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 17Phase 28Phase 33Phase 44

Open and recent trials

152 total, page 1 of 4

RECRUITING 500,000 participants

Apple Health Study

Apple

NCT06958523

RECRUITING 100,000 participants

Research Framework Exploring Sleep Health

Scripps Translational Science Institute

NCT05197738

RECRUITING NA 5,000 participants

The Effects of Sleep on Human Microbiota: Implications for Health and Disease

Mayo Clinic

NCT02573753

RECRUITING NA 1,320 participants

Comparing Two School-Based Sleep Health Interventions To Promote Sleep Quality in Youth

Children's Hospital Los Angeles

NCT07213908

RECRUITING 1,000 participants

Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders

National Institute of Mental Health (NIMH)

NCT01778504

RECRUITING 1,000 participants

Technology Exposure and Child Health: Wellness Impact and Social Effects: an Observational Product Registry Study

Aura

NCT06664944

RECRUITING NA 672 participants

A Dyadic Sleep Health Approach for Persons With Alzheimer's Disease and Caregivers

University of California, Los Angeles

NCT05452031

RECRUITING NA 584 participants

Sleep-dependent Learning in Aging

University of Massachusetts, Amherst

NCT03840083

RECRUITING NA 500 participants

Sleep Behaviors in Pregnancy

University of Michigan

NCT04205370

RECRUITING NA 500 participants

Development of the Couplet Care Bassinet

Johns Hopkins University

NCT06533449

RECRUITING NA 420 participants

Assessing Improvements in Mood and Sleep Trial

University of Pittsburgh

NCT06639477

RECRUITING Phase 2 385 participants

Cannabidiol and Older Adult Cannabis Users

University of Colorado, Boulder

NCT06290063

RECRUITING NA 360 participants

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Johns Hopkins University

NCT05663034

RECRUITING NA 340 participants

Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

Ohio State University

NCT06055036

RECRUITING NA 300 participants

Sleep and Morning Wellbeing Study

Athletic Greens International

NCT07311434

RECRUITING 300 participants

The Sweet Dreams Study - Accuracy of Sleep Trackers in Children

Arkansas Children's Hospital Research Institute

NCT06787378

RECRUITING NA 300 participants

A Sleep Hygiene Intervention to Improve Sleep Health in Urban, Latino Middle School Children

Rhode Island Hospital

NCT06942455

RECRUITING NA 220 participants

SCREENS: Sleep, Circadian Rhythms, and Electronics in the EveNing Study

Baylor College of Medicine

NCT06192745

RECRUITING Phase 2 200 participants

Sleep Trial to Prevent Alzheimer's Disease

Washington University School of Medicine

NCT04629547

RECRUITING NA 200 participants

Examination of the Dynamic Relationships of Sleep, Physical Activity, and Circadian Rhythmicity With Neurobehavioral Heterogeneity in ADHD

Hugo W. Moser Research Institute at Kennedy Krieger

NCT06810180

RECRUITING NA 200 participants

Wellness Intervention for Smoking and HIV

University of Arizona

NCT04725617

RECRUITING Phase 2 200 participants

Do Endotypes Predict Response and Sequelae in OSA Patients

University of California, San Diego

NCT04875364

RECRUITING Phase 2 188 participants

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

M.D. Anderson Cancer Center

NCT05474846

RECRUITING Phase 2 185 participants

Cannabis for Palliative Care in Cancer

University of Colorado, Boulder

NCT06266611

RECRUITING NA 180 participants

The Goodnight Screen Media Study

Baylor College of Medicine

NCT05820555

RECRUITING NA 180 participants

Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults

University of Pittsburgh

NCT06743373

RECRUITING NA 174 participants

Night Owl Sleep Study: The Effect of Sleep on Fecal Microbiota

Danis

NCT07243574

RECRUITING Phase 2 166 participants

Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype

Tiffany J. Braley, MD, MS

NCT05269628

RECRUITING NA 160 participants

Shifting Sleep Timing in Teens

Stanford University

NCT05808179

RECRUITING NA 140 participants

The Effects of a Nutritional Supplement on Sleep Quality

Athletic Greens International

NCT07345260

RECRUITING NA 120 participants

Effects of PeptiSleep on Sleep Quality in Healthy Adults

Nuritas

NCT07258433

RECRUITING NA 120 participants

Project REST: Regulation of Eating and Sleep Topography

University of Pittsburgh

NCT04057716

RECRUITING NA 120 participants

Nighttime Synchrony of Your Nutrition and Circadian Health

University of Utah

NCT07329283

RECRUITING Early Phase 1 116 participants

Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease

University of Pittsburgh

NCT05138848

RECRUITING NA 113 participants

Light Timing Study

Rush University Medical Center

NCT04753190

RECRUITING NA 105 participants

The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)

University of Alabama at Birmingham

NCT06832007

RECRUITING NA 105 participants

Human Learning of New Structured Information Across Time and Sleep

University of Pennsylvania

NCT05910762

RECRUITING 100 participants

COVID-19 Health Adjustments in Nutrition, General Wellness, and Exercise

Indiana University

NCT07128095

RECRUITING NA 100 participants

The Effects on Sleep Quality of 1:4 Reishi Liquid Extract

Efforia

NCT07294482

RECRUITING NA 100 participants

Sleep Promotion Program Primary Care

University of Pittsburgh

NCT06240325

RECRUITING NA 100 participants

Evaluating SleepWhale Drops for Rest & Resilience

Efforia

NCT07298161

RECRUITING NA 100 participants

The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity

Beth Israel Deaconess Medical Center

NCT03767426

RECRUITING NA 100 participants

Chilipad Sleep Optimization Study

Efforia

NCT07281963

RECRUITING NA 100 participants

MyVitalC: Sleep and Everyday Headache Management

Efforia

NCT07477236

RECRUITING NA 100 participants

Cognitive Training for Student Sleep and Wellness

Carnegie Mellon University

NCT07350733

RECRUITING NA 100 participants

My ESSENCE - A Research Study on Mindfulness for African-Americans With Type 2 Diabetes

University of Illinois at Chicago

NCT05208164

RECRUITING NA 100 participants

The Use of Multiple Sensors to Track Sleep in Nightshift Workers

Henry Ford Health System

NCT06670287

RECRUITING NA 96 participants

Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents

University of Pittsburgh

NCT05336084

RECRUITING NA 90 participants

Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

University of Pittsburgh

NCT06963463

RECRUITING NA 90 participants

The Effect of Sleep Loss on Emotion Regulation

Beth Israel Deaconess Medical Center

NCT05393830

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 8
Phase 3 3
Phase 4 4

Named interventions

Most-linked intervention names on Sleep records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
7 trials
Targeted memory reactivation (sounds) Behavioral
2 trials
Rested & Ready to Learn Behavioral
2 trials
Intern Health Study behavioral change mobile notification Behavioral
2 trials
Sleep Behavioral
2 trials
Transcranial Electrical Stimulation Device
2 trials
Sleep Extension Behavioral
2 trials
Regularized Sleep Schedule Behavioral
2 trials

US sites by state

Facility locations filed on Sleep trials. A trial with sites in several states counts in each.

Pennsylvania 21 trials
California 18 trials
Massachusetts 17 trials
New York 11 trials
Rhode Island 9 trials
Texas 8 trials
Maryland 8 trials
Ohio 7 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Sleep page

152 registered trials, 73 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Sleep condition card totals 152 registered trials; most-linked intervention Placebo; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.