Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Sleep clinical trials
Every US clinical trial registered for Sleep — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
152 US clinical trials · 73 currently recruiting
The research picture
Sleep has 152 registered US clinical trials, 73 of them open to new participants right now — about 48% of the total.
- 73
- recruiting participants now
- 48%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 10
- top sponsor: University of Pittsburgh
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Apple Health Study
Apple
NCT06958523
Research Framework Exploring Sleep Health
Scripps Translational Science Institute
NCT05197738
The Effects of Sleep on Human Microbiota: Implications for Health and Disease
Mayo Clinic
NCT02573753
Comparing Two School-Based Sleep Health Interventions To Promote Sleep Quality in Youth
Children's Hospital Los Angeles
NCT07213908
Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
National Institute of Mental Health (NIMH)
NCT01778504
Technology Exposure and Child Health: Wellness Impact and Social Effects: an Observational Product Registry Study
Aura
NCT06664944
A Dyadic Sleep Health Approach for Persons With Alzheimer's Disease and Caregivers
University of California, Los Angeles
NCT05452031
Sleep-dependent Learning in Aging
University of Massachusetts, Amherst
NCT03840083
Sleep Behaviors in Pregnancy
University of Michigan
NCT04205370
Development of the Couplet Care Bassinet
Johns Hopkins University
NCT06533449
Assessing Improvements in Mood and Sleep Trial
University of Pittsburgh
NCT06639477
Cannabidiol and Older Adult Cannabis Users
University of Colorado, Boulder
NCT06290063
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
Johns Hopkins University
NCT05663034
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Ohio State University
NCT06055036
Sleep and Morning Wellbeing Study
Athletic Greens International
NCT07311434
The Sweet Dreams Study - Accuracy of Sleep Trackers in Children
Arkansas Children's Hospital Research Institute
NCT06787378
A Sleep Hygiene Intervention to Improve Sleep Health in Urban, Latino Middle School Children
Rhode Island Hospital
NCT06942455
SCREENS: Sleep, Circadian Rhythms, and Electronics in the EveNing Study
Baylor College of Medicine
NCT06192745
Sleep Trial to Prevent Alzheimer's Disease
Washington University School of Medicine
NCT04629547
Examination of the Dynamic Relationships of Sleep, Physical Activity, and Circadian Rhythmicity With Neurobehavioral Heterogeneity in ADHD
Hugo W. Moser Research Institute at Kennedy Krieger
NCT06810180
Wellness Intervention for Smoking and HIV
University of Arizona
NCT04725617
Do Endotypes Predict Response and Sequelae in OSA Patients
University of California, San Diego
NCT04875364
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
M.D. Anderson Cancer Center
NCT05474846
Cannabis for Palliative Care in Cancer
University of Colorado, Boulder
NCT06266611
The Goodnight Screen Media Study
Baylor College of Medicine
NCT05820555
Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults
University of Pittsburgh
NCT06743373
Night Owl Sleep Study: The Effect of Sleep on Fecal Microbiota
Danis
NCT07243574
Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype
Tiffany J. Braley, MD, MS
NCT05269628
Shifting Sleep Timing in Teens
Stanford University
NCT05808179
The Effects of a Nutritional Supplement on Sleep Quality
Athletic Greens International
NCT07345260
Effects of PeptiSleep on Sleep Quality in Healthy Adults
Nuritas
NCT07258433
Project REST: Regulation of Eating and Sleep Topography
University of Pittsburgh
NCT04057716
Nighttime Synchrony of Your Nutrition and Circadian Health
University of Utah
NCT07329283
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
University of Pittsburgh
NCT05138848
Light Timing Study
Rush University Medical Center
NCT04753190
The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)
University of Alabama at Birmingham
NCT06832007
Human Learning of New Structured Information Across Time and Sleep
University of Pennsylvania
NCT05910762
COVID-19 Health Adjustments in Nutrition, General Wellness, and Exercise
Indiana University
NCT07128095
The Effects on Sleep Quality of 1:4 Reishi Liquid Extract
Efforia
NCT07294482
Sleep Promotion Program Primary Care
University of Pittsburgh
NCT06240325
Evaluating SleepWhale Drops for Rest & Resilience
Efforia
NCT07298161
The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity
Beth Israel Deaconess Medical Center
NCT03767426
Chilipad Sleep Optimization Study
Efforia
NCT07281963
MyVitalC: Sleep and Everyday Headache Management
Efforia
NCT07477236
Cognitive Training for Student Sleep and Wellness
Carnegie Mellon University
NCT07350733
My ESSENCE - A Research Study on Mindfulness for African-Americans With Type 2 Diabetes
University of Illinois at Chicago
NCT05208164
The Use of Multiple Sensors to Track Sleep in Nightshift Workers
Henry Ford Health System
NCT06670287
Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents
University of Pittsburgh
NCT05336084
Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
University of Pittsburgh
NCT06963463
The Effect of Sleep Loss on Emotion Regulation
Beth Israel Deaconess Medical Center
NCT05393830
A Mobile App to Improve 24-Hour Movement Guideline Adherence in Preschoolers
University of Kansas Medical Center
NCT06667661
Bedtime Stories: Tailored Sleep Health Messaging for Caregivers
Boston Children's Hospital
NCT06618040
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
Nathaniel Jenkins
NCT06454344
Effect of Sleep Extension on Ceramides in People with Overweight and Obesity
University of Utah
NCT06180837
Sleep and Physical Activity in Patient and Caregiver Dyads Following Allogeneic Hematopoietic Cell Transplantation
M.D. Anderson Cancer Center
NCT07140770
Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty
University of Miami
NCT06902285
Student Exercise and Sleep Timing Study - Part 2
Rutgers, The State University of New Jersey
NCT06336590
Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
Beth Israel Deaconess Medical Center
NCT05026541
Home Sleep Therapy for Older Adults With MCI
Brain Electrophysiology Laboratory Company
NCT05771844
The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors
Arizona State University
NCT06938555
The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers
Rhode Island Hospital
NCT06737055
Sleepless at Scripps: An Inpatient White Noise Study
Scripps Health
NCT05475262
Optimizing Attention and Sleep Intervention Study
University of Pittsburgh
NCT05683756
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
Brigham and Women's Hospital
NCT06989619
Sleep and Circadian Mechanisms in Hypertension
Oregon Health and Science University
NCT05184933
Repurposing Low-Dose Clonidine for PTSD in Veterans
Wake Forest University Health Sciences
NCT04877093
The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU
Massachusetts General Hospital
NCT04737200
Aerobic Exercise: A Potential Rescue From the Negative Ramifications of Poor Sleep
Florida State University
NCT06956963
Lemborexant Treatment of Insomnia Linked to Epilepsy
University of Manitoba
NCT06262594
Sleep Duration and Cardiovascular Health
Oregon Health and Science University
NCT04804124
Impact of Exogenous Ketones on Sleep and Breathing in Healthy Volunteers (K-SLEEP)
Johns Hopkins University
NCT07224074
Light Exposure, Migraine Outcomes, and Sleep Quality
Arizona State University
NCT07476053
Circadian Intervention to Improve Cardiometabolic Health
University of Utah
NCT05943626
Intern Health Study 2024
University of Michigan
NCT06465680
Predictors of De-novo Development of Obstructive Sleep Apnea in Pregnancy
The Miriam Hospital
NCT02917876
Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP)
The Miriam Hospital
NCT02412696
Evaluation of SLEEP Program
Michigan State University
NCT04727619
Evaluation of a Neurostimulation Device for Insomnia: A Randomized Trial
ProofPilot
NCT04627480
Diet, Food, Exercise and Nutrition During Social Distancing
University of Arkansas, Fayetteville
NCT04754074
SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty
Scripps Health
NCT04247646
Rested & Ready to Learn
University of South Carolina
NCT06882005
Impact of Sleep Extension in Adolescents
University of Colorado, Denver
NCT03500458
Sleep and Inflammatory Resolution Pathway
Beth Israel Deaconess Medical Center
NCT03377543
Sleep and Vascular Health Study
Auburn University
NCT05918744
Improving Sleep, Decision-Making, and Eating in Adolescents with Obesity
Drexel University
NCT06745570
Partial Sleep Restriction in Chronic Low Back Pain: A Feasibility Study
University of Kansas Medical Center
NCT07008924
Sleep Improvement Via Environmental Smart Temperature Adjustments
Hebrew SeniorLife
NCT06770400
Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine
Washington University School of Medicine
NCT04206059
Intern Health Study 2022 and 2023
University of Michigan
NCT05436145
Apnea Positive Pressure Long-Term Efficacy Study
Stanford University
NCT00051363
Investigation of Sleep in the Intensive Care Unit
Massachusetts General Hospital
NCT03355053
VISC-Q Trial (Validation of an Online Sleep Characterization Questionnaire)
Philips Respironics
NCT03590795
Impact of Sleep Workshops in College Students
NYU Langone Health
NCT02665247
A Study to Assess the Effects of Dietary Supplement Drinks on Sleep, Stress and Mood
The Water Street Collective
NCT06378567
Enhancing Sleep Duration: Effects on Children's Eating and Activity Behaviors-Renewal
Temple University
NCT03186508
Hangover, Congeners, Sleep and Occupational Performance
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT00247585
Nature and Health: How Does Lifestyle and Environment Affect Health and Wellness
Stanford University
NCT06001697
A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults
Johns Hopkins University
NCT03959202
A Study to Evaluate the Effect of SlimBiotics Probiotic Formula on Weight Management and Metabolic Health Outcomes
Slimbiotics
NCT05917314
Examining the Biological Factors That Affect Sleep Duration
Brigham and Women's Hospital
NCT00607204
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 8 |
| Phase 3 | 3 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Sleep Trial Landscape
ClinicalTrials.gov lists 152 US studies indexed under Sleep, and 73 of those are currently open to recruitment — roughly 48% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Sleep shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Sleep is led by University of Pittsburgh with 10 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Sleep?
PlainTrial tracks 152 US clinical trials for Sleep, of which 73 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Sleep?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.